Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial

Rubin, Richard R.; Peyrot, Mark; Wang, Nae Yuh; Coughlin, Janelle W.; Jerome, Gerald J.; Fitzpatrick, Stephanie L.; Bennett, Wendy L; Dalcin, Arlene; Daumit, Gail L.; Durkin, Nowella; Chang, Yi; Yeh, Hsin Chieh; Louis, Thomas A.; Appel, Lawrence J.

doi:10.1007/s11136-013-0363-3

Cited by 24 publications

(38 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We observed only one significant difference in sleep duration or quality between the three randomized treatment groups in the POWER-UP trial, potentially because the differences in weight loss between the Usual Care group and two lifestyle interventions were not sufficiently large (ranging from 1.5 to 4.6 kg at month 6 and from 1.7 to 2.9 kg at month 24). Rubin et al (31) similarly observed no significant differences in sleep quality between the control and two intervention groups in the 2-year Hopkins POWER trial, which used similar methods and outcomes as our POWER-UP study. These investigators, however, did not include analyses that examined the percentage of participants who achieved optimal sleep duration or the effects on outcomes of losing 5% vs. <5%.…”

Section: Discussionsupporting

confidence: 50%

“…These investigators, however, did not include analyses that examined the percentage of participants who achieved optimal sleep duration or the effects on outcomes of losing ≥5% vs. <5%. Additional studies of the relationship between weight loss and sleep quality are needed in which participants achieve a larger range of weight losses, as compared with those obtained in the two POWER studies . In addition, study is needed of factors associated with the deterioration in improved sleep quality, observed in participants in this study who lost ≥5% of initial weight at month 6.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Effects of a 2‐year behavioral weight loss intervention on sleep and mood in obese individuals treated in primary care practice

Alfaris

Wadden

Sarwer

et al. 2015

Obesity

View full text Add to dashboard Cite

ObjectiveTo examine the effect of weight loss on sleep duration, sleep quality, and mood in 390 obese men and women who received one of three behavioral weight loss intervention in the Practice-based Opportunities for Weight Reduction trial at the University of Pennsylvania (POWER-UP).MethodsSleep duration and quality were assessed at baseline and months 6 and 24 by the Pittsburgh Sleep Quality Index (PSQI) questionnaire and mood by the Patient Health Questionnaire-8 (PHQ-8). Changes in sleep and mood were examined according to treatment group and based on participants’ having lost ≥5% of initial weight vs <5%.ResultsThere were few significant differences between treatment groups in changes in sleep or mood. At month 6, however, mean (±SD) min of sleep increased significantly more in participants who lost ≥5% vs <5% (21.6±7.2 vs 1.2±6.0 min, p=0.0031). PSQI total scores similarly improved (declined) more in those who lost ≥5% vs <5% (−1.2±0.2 vs −0.4±0.2, p < 0.001), as did PHQ scores (−2.5±0.4 vs −0.1±0.3, p <0.0001). At month 24, only the differences in mood remained statistically significant (p < 0.05).ConclusionLosing ≥ 5% of initial weight was associated with short-term improvements in sleep duration and sleep quality, as well as favorable short- and long-term changes in mood.

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 92%

Effects of a 2‐year behavioral weight loss intervention on sleep and mood in obese individuals treated in primary care practice

Alfaris

Wadden

Sarwer

et al. 2015

Obesity

View full text Add to dashboard Cite

show abstract

“…A large number of observational studies suggest that the prevalence of cardiovascular disease and the incidence of acute atherothrombotic events can be reduced through long-term intentional weight loss (172,173,179,180,198,224). However, many questions about the amount and duration of weight loss required to produce a significant effect on cardiovascular outcomes, as well as the impact of different strategies to achieve and sustain weight loss, remain unresolved.…”

Section: Effect Of Sustained Weight Loss On Major Cardiovascular Disementioning

confidence: 99%

Health Benefits of Long-Term Weight-Loss Maintenance

2015

View full text Add to dashboard Cite

Obesity is a chronic and complex medical condition associated with a large number of complications affecting most organs and systems through multiple pathways. Strategies for weight management include behavioral, pharmacological, and surgical interventions, all of which can result in a reduction in obesity-related comorbidities and improvements in quality of life. However, subsequent weight regain often reduces the durability of these improvements. The objective of this article is to review evidence supporting the long-term effects of intentional weight loss on morbidity, mortality, quality of life, and health-care cost. Overall, considerable evidence suggests that intentional weight loss is associated with clinically relevant benefits for the majority of obesity-related comorbidities. However, the degree of weight loss that must be achieved and sustained to reap these benefits varies widely between comorbidities.

show abstract

“…Several studies also suggest that behavioral weight loss interventions facilitate short-term reductions in depression symptoms, as assessed by the Beck Depression Inventory (BDI) (15–18), as well as improvements in the physical health component of quality of life (19–22). However, only a few studies of weight loss and mood were conducted in persons with type 2 diabetes, and none followed participants for more than 4 years.…”

Section: Introductionmentioning

confidence: 99%

Impact of Intensive Lifestyle Intervention on Depression and Health-Related Quality of Life in Type 2 Diabetes: The Look AHEAD Trial

Rubin¹,

Wadden²,

Bahnson³

et al. 2014

Diabetes Care

180

113

View full text Add to dashboard Cite

OBJECTIVEWe examined the effects of an intensive lifestyle intervention (ILI), compared with a diabetes support and education (DSE) control intervention, on long-term changes in depression symptoms, antidepressant medication (ADM) use, and health-related quality of life (HRQoL) in overweight/obese individuals with type 2 diabetes.RESEARCH DESIGN AND METHODSLook AHEAD was a multisite randomized controlled trial of 5,145 overweight/obese participants assigned to ILI (designed to produce weight loss) or DSE and followed for a median of 9.6 years. The Beck Depression Inventory (BDI) was administered at baseline, annually at years 1–4, and again at year 8. Mean BDI scores and incidence of BDI scores ≥10, indicative of likely mild or greater depression, were examined. Annually through year 10, participants reported their ADM use and completed the Medical Outcomes Study Short Form 36 (SF-36) questionnaire, which yields physical component summary (PCS) and mental component summary (MCS) scores.RESULTSILI significantly reduced the incidence of mild or greater depression symptoms (BDI scores ≥10) compared with DSE (hazard ratio [HR] = 0.85; 95% CI 0.75–0.97; P = 0.0145). Although SF-36 PCS scores worsened over time in both groups, ILI participants reported better physical function than DSE throughout the first 8 years (all P values <0.01). There were no significant differences between treatment arms in the proportion of participants who used ADMs or in SF-36 MCS scores.CONCLUSIONSILI for overweight/obese patients with type 2 diabetes may reduce the risk of developing clinically significant symptoms of depression and preserve physical HRQoL. These findings should be considered when evaluating the potential benefits of ILIs.

show abstract

Patient-reported outcomes in the practice-based opportunities for weight reduction (POWER) trial

Cited by 24 publications

References 35 publications

Effects of a 2‐year behavioral weight loss intervention on sleep and mood in obese individuals treated in primary care practice

Effects of a 2‐year behavioral weight loss intervention on sleep and mood in obese individuals treated in primary care practice

Health Benefits of Long-Term Weight-Loss Maintenance

Impact of Intensive Lifestyle Intervention on Depression and Health-Related Quality of Life in Type 2 Diabetes: The Look AHEAD Trial

Contact Info

Product

Resources

About