Patient-Reported Outcomes Following Intra-articular Hyaluronic Acid for Knee Osteoarthritis

Habibi, Akram; Karia, Raj; Ward, Spencer; Schwarzkopf, Ran; Rozell, Joshua C.; Slover, James

doi:10.1016/j.arth.2023.03.079

Cited by 1 publication

(1 citation statement)

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“…The oxidative stress in general is a part of the inflammatory reaction. Contrary to intuitive reasoning, the intra-articular application of oxygen and ozone has a protective potential with effect which is comparable to intraarticular hyaluronic acid (HA) application [104][105][106]. The oxygen-ozone intra-articular application presents a low risk of complications yet its efficacy remains controversial.…”

Section: Further Questions and Few Answersmentioning

confidence: 99%

Why Does Rehabilitation Not (Always) Work in Osteoarthritis? Does Rehabilitation Need Molecular Biology?

Zdziechowski

Gluba-Sagr

Rysz

et al. 2023

IJMS

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Osteoarthritis (OA) is a common disease among the human population worldwide. OA causes functional impairment, leads to disability and poses serious socioeconomic burden. The rehabilitation offers a function-oriented method to reduce the disability using diverse interventions (kinesiotherapy, physical therapy, occupational therapy, education, and pharmacotherapy). OA as a widespread disease among elderly patients is often treated by rehabilitation specialists and physiotherapists, however the results of rehabilitation are sometimes unsatisfactory. The understanding of molecular mechanisms activated by rehabilitation may enable the development of more effective rehabilitation procedures. Molecular biology methods may prove crucial in rehabilitation as the majority of rehabilitation procedures cannot be estimated in double-blinded placebo-controlled trials commonly used in pharmacotherapy. This article attempts to present and estimate the role of molecular biology in the development of modern rehabilitation. The role of clinicians in adequate molecular biology experimental design is also described.

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Section: Further Questions and Few Answersmentioning

confidence: 99%