Patient-reported health status during pediatric cancer treatment

Dobrozsi, Sarah; Yan, Ke; Hoffmann, Raymond G.

doi:10.1002/pbc.26295

Cited by 24 publications

(35 citation statements)

References 22 publications

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“…35 Young patients with leukemia experience more pronounced impairments in physical, emotional, and social health than patients affected by CNS tumors and other solid tumors. 36 Moreover, they spend more time in the hospital, and this leads to a higher burden on parents because of absences from work and negative effects on their relational network. 37 In our cohort, mortality rates from leukemia decreased over 6 year of follow-up, whereas no significant changes were observed for CNS neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Alicandro

Bertuccio

Sebastiani

et al. 2020

Cancer

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BACKGROUND: Progress in the treatment of juvenile cancers has led to remarkable improvements in survival. However, not all families have the resources to cope with the burden that such diseases require. This study was aimed at evaluating the association between parental education and cancer mortality in children, adolescents, and young adults. METHODS: This was a case-cohort study based on 1889 cancer cases and 108,387 noncases sampled from the 2011 Italian census cohort of 10,964,837 individuals younger than 20 years and followed for 6 years. Mortality rate ratios (MRRs) were estimated for individuals with parents with high and intermediate levels of education (International Standard Classification of Education [ISCED] levels 5-8 and 3-4, respectively) in comparison with individuals with less educated parents (ISCED levels < 3) through multiple Poisson regression models. RESULTS: Over the follow-up, 684, 858, and 347 cancer cases with parents with the lowest, intermediate, and highest levels of education, respectively, were registered. In comparison with the individuals with parents with the lowest level of education, the MRR from all neoplasms was 0.92 (95% confidence interval [CI], 0.83-1.03) for those with parents with an intermediate level of education and 0.83 (95% CI, 0.72-0.95) for those with parents with the highest level of education. The MRRs from all neoplasms for individuals with parents with the highest level of education were 0.88 (95% CI, 0.69-1.11) among children, 0.87 (95% CI, 0.70-1.06) among adolescents, and 0.64 (95% CI, 0.50-0.83) among young adults. CONCLUSIONS: Children, adolescents, and young adults with highly educated parents have reduced mortality from cancer. This calls for further efforts to optimize treatment for children of less educated parents. Cancer 2020;126:4753-4760.

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Section: Discussionmentioning

confidence: 99%

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Alicandro

Bertuccio

Sebastiani

et al. 2020

Cancer

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“…The measure has been tested in a large and diverse group of children and adolescents in curedirected cancer treatment and in survivors of childhood cancer, in a group of children and adolescents aged 8-18 years enrolled in phase 1 and 2 clinical trials for incurable cancer, and in a group of 40 pediatric patients with cancer during the first six months of their treatment (Dobrozsi et al, 2017;Hinds et al, 2013Hinds et al, , 2017. The findings indicate that the PROMIS Pediatric Fatigue Short Form measure is unidimensional, internally consistent, and has criterion validity (Dobrozsi et al, 2017;Hinds et al, 2013Hinds et al, , 2017. Using additional items increased reliability, but short forms consistently demonstrate reliability of 0.85 over 2 to 4 standard deviations (Hinds et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

“…Feasibility, acceptability, reliability, and knowngroup validity of the original eight PROMIS pediatric measures have been established in pediatric patients with cancer in cure-directed treatment, in survivorship, and in enrollment in phase 1 or 2 trials for incurable cancer (Dobrozsi et al, 2017;Hinds et al, 2013Hinds et al, , 2017. Evaluating the measures' responsiveness to capture change over time is essential to inform their use in clinical trials.…”

Section: Measuring Cancer-related Fatigue In Children and Adolescentsmentioning

confidence: 99%

Comparison of Legacy Fatigue Measures With the PROMIS Pediatric Fatigue Short Form

Macpherson

Wang

DeWalt

et al. 2018

ONF

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“…Children are able to complete symptom assessments in multiple domains at multiple time points during chemotherapy with excellent enrollment rates and minimal attrition. [19,20] Trials with longer surveillance periods (greater than three months) show lower enrollment rates, with less adherence to repeated measures[18,21], but demonstrate, nonetheless, the viability of the concept and illustrate essential aspects of the childhood cancer experience: that symptoms fluctuate over the duration of treatment, different chemotherapy regimens result in different symptoms; and that the individual response to treatment is widely variable. The theme of “invisible” symptom prevalence is again noted[18,20], lending importance to providing a standard method for patients to provide this information directly to their healthcare team.…”

Section: Feasibility Of Monitoring Symptoms With Pro Measuresmentioning

confidence: 99%

Symptom Monitoring in Pediatric Oncology Using Patient-Reported Outcomes: Why, How, and Where Next

Leahy

Feudtner

Basch

2017

Patient

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Symptom monitoring using patient-reported outcomes (PROs) is not common in pediatric oncology, despite interest from stakeholders-including patients, families, clinicians, and regulatory organizations-and proven clinical benefit in adult oncology. This article examines the foundational data for patient-reported symptom reporting in this population and posits the next investigative steps toward the implementation of patient-reported symptom monitoring in the care and research of pediatric oncology patients. The reasoning behind, and feasibility of, monitoring symptoms in pediatric oncology patients using PRO measures are discussed, as well as specific tools that have been developed to track symptoms in this population, including innovative electronic self-reporting platforms built to engage children in the symptom reporting process. Aspects of engaging both patients and clinicians in the symptom self-report process are reviewed, as are the experiences of "early adopters" of this process in pediatric oncology and across pediatrics. It is clear that there are key issues that remain regarding the use of PROs for symptom monitoring, including selection of specific outcomes to monitor, how to resolve discrepant reports, and determination of benefit. The next steps for investigation of these issues are discussed. Unanswered questions notwithstanding, work should continue to make patient-reported symptom monitoring an established, evidence-based part of routine and research practice in pediatric oncology.

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Patient-reported health status during pediatric cancer treatment

Cited by 24 publications

References 22 publications

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Parental education and cancer mortality in children, adolescents, and young adults: A case‐cohort study within the 2011 Italian census cohort

Comparison of Legacy Fatigue Measures With the PROMIS Pediatric Fatigue Short Form

Symptom Monitoring in Pediatric Oncology Using Patient-Reported Outcomes: Why, How, and Where Next

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