2016
DOI: 10.1371/journal.pone.0150866
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Abstract: BackgroundPeriprosthetic joint infections (PJIs) are dreaded complications of total joint arthroplasties. The risk of developing PJIs is likely to be influenced by several patient factors such as sociodemographic characteristics, body mass index (BMI), and medical and surgical histories. However, the nature and magnitude of the long-term longitudinal associations between these patient-related factors and risk of developing PJIs are uncertain.ObjectiveTo conduct a systematic review and meta-analysis to assess t… Show more

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Cited by 320 publications
(224 citation statements)
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References 57 publications
(56 reference statements)
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“…The age standardized rate of TKA infection was 1.26% for recipients with RA, compared to 0.84% for recipients with OA, with an adjusted Hazard Ratio (HR) of 1.47, P = 0.03, confirmed in a recent meta-analysis demonstrating a relative risk of 1.7 for patients with RA [11,29]. For patients with SLE whose disease was severe enough to warrant hospitalization within 6 months of surgery, a large study based on Taiwan's National Health Insurance Research Database found the risk of septicaemia to be markedly increased after surgeries including orthopedic procedures (OR = 3.43, 95% CI 2.48 to 4.74) [14].…”
Section: Infectionmentioning
confidence: 92%
See 1 more Smart Citation
“…The age standardized rate of TKA infection was 1.26% for recipients with RA, compared to 0.84% for recipients with OA, with an adjusted Hazard Ratio (HR) of 1.47, P = 0.03, confirmed in a recent meta-analysis demonstrating a relative risk of 1.7 for patients with RA [11,29]. For patients with SLE whose disease was severe enough to warrant hospitalization within 6 months of surgery, a large study based on Taiwan's National Health Insurance Research Database found the risk of septicaemia to be markedly increased after surgeries including orthopedic procedures (OR = 3.43, 95% CI 2.48 to 4.74) [14].…”
Section: Infectionmentioning
confidence: 92%
“…Infection is the most common cause for prosthetic joint failure, and the overall risk of infection is increased in patients with RA, SPA, and SLE [11,[25][26][27][28][29]. The age standardized rate of TKA infection was 1.26% for recipients with RA, compared to 0.84% for recipients with OA, with an adjusted Hazard Ratio (HR) of 1.47, P = 0.03, confirmed in a recent meta-analysis demonstrating a relative risk of 1.7 for patients with RA [11,29].…”
Section: Infectionmentioning
confidence: 99%
“…Prosthetic joint infections range from 0.5–5% depending on the location(3135). Hip and shoulder prostheses have relatively low incidence of infection (~1%)(31, 35) while elbows have significantly higher (5%)(34). The reason for this difference remains unclear.…”
Section: The Clinical Problemmentioning
confidence: 99%
“…Infections occurring within 2 years of surgery are usually acquired during the operation, while infections occurring beyond 2 years are predominantly acquired through seeding from blood (Zimmerli, Trampuz, & Ochsner, ). Histories of diabetes, rheumatoid arthritis, depression, steroid use and previous joint surgery are associated with an increased risk of developing PJI (Kunutsor, Whitehouse, Blom, Beswick, & Team, ). Symptoms include inflammation, severe pain, loss of function, discharge from the surgical wound, fever and nausea; if left untreated, infections can result in disability and death (Hunter & Dandy, ; Zimmerli et al, ).…”
Section: Introductionmentioning
confidence: 99%