2016
DOI: 10.1097/shk.0000000000000692
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Implantable Device-Related Infection

Abstract: Over half of the nearly 2 million healthcare-associated infections can be attributed to indwelling medical devices. In this review we highlight the difficulty in diagnosing implantable device related infection and how this leads to a likely underestimate of the prevalence. We then provide a length-scale conceptualization of device related infection pathogenesis. Within this conceptualization we focus specifically on biofilm formation and the role of host immune and coagulation systems. Using this framework, we… Show more

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Cited by 199 publications
(167 citation statements)
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“…Medical device-related infections are among the most common healthcare-associated infections (HAIs), causing increased morbidity and mortality on patients, which poses an abundant economic burden on healthcare services [ 1 , 2 ]. The considerable difficulty in the treatment of these infections stems mainly from the microorganisms’ ability to form biofilms.…”
Section: Introductionmentioning
confidence: 99%
“…Medical device-related infections are among the most common healthcare-associated infections (HAIs), causing increased morbidity and mortality on patients, which poses an abundant economic burden on healthcare services [ 1 , 2 ]. The considerable difficulty in the treatment of these infections stems mainly from the microorganisms’ ability to form biofilms.…”
Section: Introductionmentioning
confidence: 99%
“…Quorum sensing (QS) is a bacterial type of cell–cell communication by which bacteria regulates the expression of specific genes involved in biofilm formation, adhesion, antibiotic synthesis, virulence, swarming, bioluminescence, mating, and tissue damage (Bassler, ; Davies, Parsek, Pearson, Iglewski, & Costerton, ). For example, bacteria sense and regulate the growth of bacterial group via QS effects and form biofilm on implant surface (VanEpps & Younger, ). It contributes to the antimicrobial resistance that leads to the failure of anti‐infection treatment after implant surgery since biofilm not only retards the diffusion of antibiotics, but also prevents pathogenic bacteria from attacking of immune cells.…”
Section: Introductionmentioning
confidence: 99%
“…The process by which bacteria adhere to, colonize, and infect a device is not fully understood, as it occurs on a multi-length scale and involves several physical, chemical, and biological aspects [137]. Therefore, biomaterial science integrated with nanotechnology and microfabrication could empower the intrinsic ability of some natural and biosynthetic polymers towards safer and better performing biomedical devices.…”
Section: Clinical Relevance and Future Perspectivesmentioning
confidence: 99%