Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study

Bai, Baoyan; Xu, Zhe; Hu, Yan; Qu, Mengmeng; Cheng, Juan; Luo, Shengdong; Yao, Zilong; Gao, Hongyan; Ma, Yenv; Gao, Rong; Hou, Jun; Xin, Shaojie; Mao, Panyong

doi:10.1186/s40001-021-00515-9

Cited by 4 publications

(10 citation statements)

References 38 publications

(43 reference statements)

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“…29 Increased NLR has been associated with severe disease, enhancing the evidence of the increased inflammatory response in COVID-19. 6,12 Raised NLR significantly increased likelihood of death or ICU admission. Sensitivity and NPV for ICU admission were good, however less so for death.…”

Section: Discussionmentioning

confidence: 95%

“…3,6,22,27 Neutrophils play a critical function in the clearance of pathogens and an important role in the inflammatory response in COVID-19. 6,28 Recognition of the virus by the neutrophils occurs through pattern recognition receptors and Toll-like receptors. Stimulation of these receptors activates downstream signaling cascades, causing the production of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Higher leukocyte counts have been associated with increased mortality in COVID-19. 3,6,22,27 Neutrophils play a critical function in the clearance of pathogens and an important role in the inflammatory response in COVID-19. 6,28 Recognition of the virus by the neutrophils occurs through pattern recognition receptors and Toll-like receptors.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet production by megakaryocytes is regulated mainly through thrombopoietin, produced by the liver, and other inflammatory cytokines such as interleukin‐3 (IL‐3), IL‐6, and stem cell factor 34 . These cytokines can promote the production of platelets during inflammation, which may explain the reported elevation of platelet counts in the early phase of COVID‐19 3,6,35 . Changes in platelet count in COVID‐19 can be due to several reasons including the effect of cytokines, inhibition of platelet production by SARS‐CoV2 infection, platelet consumption in COVID‐19‐associated lung damage and associated‐thrombosis, and the effect of therapeutic agents 7 .…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Coronavirus disease 2019 (COVID-19) is associated with multisystem complications and hematological abnormalities of variable severity. [4][5][6] The correlation between early changes in hematological parameters and disease outcome, is under active investigation. 4,5,[7][8][9] Hematological changes reported include changes in full blood count (FBC) parameters, abnormal morphological characteristics of blood cells on peripheral blood smear examination and derangement of hemostatic parameters, referred to as COVID-19-associated coagulopathy (CAC).…”

Section: Introductionmentioning

confidence: 99%

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Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Abdullah

Cornelissen

Musekwa

et al. 2022

Health Science Reports

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Background: Coronavirus disease 2019 (COVID-19) is associated with hematological abnormalities of variable severity. The full blood count (FBC) and leukocyte differential count (DIFF) could facilitate the prediction of disease severity and outcome in COVID-19. This study aimed to assess the hematological parameters in early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their correlation with disease outcome. Methods: A retrospective cross-sectional descriptive study was performed. Adults with a FBC and positive SARS-CoV-2 polymerase chain reaction results between March 1, and June 31, 2020 were reviewed. Basic hematological parameters (FBC, DIFF) and human immunodeficiency virus (HIV) status were recorded. Outcome measures were admission to a general ward or intensive care unit (ICU), recovery or death.Results: Six hundred and eighty-five cases median age 51 years, were analyzed.Forty-four percent were males and fourteen percent were HIV-positive with no association between death and/or ICU admission (p = 0.522 and p = 0.830, respectively). Leucocytosis was predictive of ICU admission (odds ratio [OR]: 2.4, confidence interval [CI]: 1.77-3.8186) and neutrophilia, of both mortality (OR: 1.5, CI: 1.0440-2.0899) and ICU admission (OR: 4, CI: 2.5933-6.475). Median lymphocyte count was decreased and D-dimer raised, showing no significant association with outcome. Raised neutrophil-to-lymphocyte-ratio (NLR) was associated with increased odds of mortality (OR: 2.5, CI: 1.3556-3.2503) and ICU admission (OR: 4.8, CI: 2.4307-9.5430) as was monocyte-to-lymphocyte-ratio (MLR) (OR: 2, CI: 1.3132-2.9064) and (OR: 2.3, CI: 1.0608-1.9935), respectively. Hospital admission and older age were significantly associated with mortality (p = 0.0008 and p < 0.0001), respectively.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Abdullah

Cornelissen

Musekwa

et al. 2022

Health Science Reports

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Predictors of mortality of hospitalized COVID-19 pneumonia patients in university hospital

Wafy,

Saman,

Ahmed

2024

Egypt J Bronchol

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Introduction COVID-19 pneumonia is a leading cause for worse outcome of infected patients. Factors associated with mortality in COVID-19 pneumonia vary among studies; identification of most possible factors related to worse outcome might add for management. Patients and methods Consecutive COVID-19 pneumonia patients referred to the Assiut University Hospital, Egypt, from June 2020 to August 2022 were included in our study. All the included patients were followed up from admission until discharge to identify the factors that worsen the outcome. Our cohort study includes two groups: survivors and non-survivors. Clinical, laboratory, and management data of both groups were recorded. Results Two-hundred and fifty-one confirmed COVID-19 pneumonia patients were included in the study; 147 (58.6%) patients were improved (survivors’ group), and 104 (41.4%) patients were deteriorated and died (non-survivors’ group). Non-survivors’ group had significantly higher MMRC dyspnea scale, pneumonia severity index, CURB-65 score, and baseline respiratory rate. Non-survivors group had significantly lower mean lymphocytes (0.81 ± 0.61 vs. 1.25 ± 0.75; p < 0.001), higher ferritin (1272.45 ± 143.76 vs. 615.84 ± 75.47; p < 0.001), and higher d-dimer (6.65 ± 2.67 vs. 2.78 ± 0.38; p < 0.001), with interestingly significantly higher mean platelet volume (MPV) (10.34 ± 1.64 vs. 10.07 ± 1.93 (fl); p < 0.001). Non-survivors group was frequently admitted to ICU (88 (84.6%) vs. 38 (25.9%); p < 0.001) and had longer duration in ICU than survivors group (9.71 ± 3.36 vs. 5.90 ± 2.34 (days); p < 0.001). The predictors for mortality among patients with COVID-19 pneumonia were old age, high MPV, high CT score, and admission to ICU. Conclusion Old age, severe lung infiltrate with HRCT, high mean platelet volume, and ICU admission are the main clinical determinants of worse outcome of COVID-19 pneumonia.

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Haematological predictors of poor outcome among COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa

et al. 2022

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Background Studies from Asia, Europe and the USA indicate that widely available haematological parameters could be used to determine the clinical severity of Coronavirus disease 2019 (COVID-19) and predict management outcome. There is limited data from Africa on their usefulness in patients admitted to Intensive Care Units (ICUs). We performed an evaluation of baseline haematological parameters as prognostic biomarkers in ICU COVID-19 patients. Methods Demographic, clinical and laboratory data were collected prospectively on patients with confirmed COVID-19, admitted to the adult ICU in a tertiary hospital in Cape Town, South Africa, between March 2020 and February 2021. Robust Poisson regression methods and receiver operating characteristic (ROC) curves were used to explore the association of haematological parameters with COVID-19 severity and mortality. Results A total of 490 patients (median age 54.1 years) were included, of whom 237 (48%) were female. The median duration of ICU stay was 6 days and 309/490 (63%) patients died. Raised neutrophil count and neutrophil/lymphocyte ratio (NLR) were associated with worse outcome. Independent risk factors associated with mortality were age (ARR 1.01, 95%CI 1.0–1.02; p = 0.002); female sex (ARR 1.23, 95%CI 1.05–1.42; p = 0.008) and D-dimer levels (ARR 1.01, 95%CI 1.002–1.03; p = 0.016). Conclusions Our study showed that raised neutrophil count, NLR and D-dimer at the time of ICU admission were associated with higher mortality. Contrary to what has previously been reported, our study revealed females admitted to the ICU had a higher risk of mortality.

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Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study

Cited by 4 publications

References 38 publications

Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Predictors of mortality of hospitalized COVID-19 pneumonia patients in university hospital

Haematological predictors of poor outcome among COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa

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