Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Abdullah, Ibtisam; Cornelissen, Helena; Musekwa, Ernest; Zemlin, Annalise E; Jalavu, Thumeka P.; Mashigo, Nomusa; Chetty, Carissa; Nkosi, Nokwazi; Chapanduka, Zivanai C.

doi:10.1002/hsr2.550

Cited by 8 publications

(10 citation statements)

References 36 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study carried out in Southern Africa showed that leukocytosis and neutrophilia are diseases highly associated with the death of older people due to Covid-19, since the high count of leukocytes and neutrophils can cause cascades of inflammation with the production of inflammatory cytokines. This process is also associated with the progression to more serious conditions and death from Covid-19 ( 22 ) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná

Inoue,

Baccon,

Pesce

et al. 2023

Rev. esc. enferm. USP

View full text Add to dashboard Cite

Objective: To estimate the prevalence and to analyze the factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná. Method: Cross-sectional study conducted with secondary data from older people with a positive diagnosis of Covid-19 living in the State of Paraná, collected from March 1, 2020 to August 31, 2021. Prevalence ratios were obtained by adjusting the regression model. Results: A total of 16,153 deaths of older people hospitalized in the State of Paraná were analyzed. The adjusted model revealed an association between death and some factors such as: belonging to the age group of 75 to 84 years (PR = 1.28; CI95% = 1.24–1.32) and 85 years or over (PR = 1.52; CI95% = 1.45–1.59); male (PR = 1.17; CI95% = 1.13–1.21); obesity (PR = 1.23; CI95% = 1.16–1.29); other morbidities (PR = 1.25; CI95% = 1.20–1.30); and having used ventilatory support (PR = 2.60; CI95% = 2.33–2.86). Older people vaccinated against influenza had a probability of death reduced by 11% (PR = 0.89; CI95% = 0.86–0.93). Conclusion: The association of age, sex, and diagnosis of previous comorbidities with unfavorable outcomes from Covid-19 was identified. Having received the flu vaccine provided protection to elderly people who contracted SARS-CoV-2.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná

Inoue,

Baccon,

Pesce

et al. 2023

Rev. esc. enferm. USP

View full text Add to dashboard Cite

show abstract

“…Monitoring these ratios can help identify individuals at higher risk for such complications and facilitate early intervention. [39] 3. Personalized treatment: The use of inflammation ratios can guide personalized treatment strategies.…”

Section: Mlr In Hivmentioning

confidence: 99%

“…Treatment decisions can be tailored based on these ratios to optimize therapeutic outcomes. [39] 4. Immunological recovery: Improvements in inflammation ratios, such as a rising CD4/CD8 ratio, can signify immune recovery in response to effective ART.…”

Section: Mlr In Hivmentioning

confidence: 99%

See 1 more Smart Citation

Utilization of immunological ratios in HIV: Implications for monitoring and therapeutic strategies

Obeagu,

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Human immunodeficiency virus (HIV) infection remains a significant global health concern, necessitating ongoing research and innovation in the quest for improved disease management. Traditional markers for monitoring HIV progression and the effectiveness of antiretroviral therapy have limitations in capturing the intricate immune responses and inflammatory dynamics in people with HIV. In recent years, the concept of inflammation ratios has gained prominence as a valuable tool for assessing and understanding the complex interplay between inflammation, immune function, and HIV. In this abstract, we provide an overview of the emerging field of utilizing inflammation ratios in the context of HIV and its implications for disease monitoring and therapeutic strategies. These ratios, such as the CD4/CD8 ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio, offer a more comprehensive assessment of an individual’s immune status and inflammatory state. By exploring the clinical implications of inflammation ratios, including their potential to predict disease complications and guide personalized treatment approaches, this publication sheds light on the potential benefits of incorporating inflammation ratios into routine HIV care. Furthermore, we emphasize the importance of ongoing research in this field to further refine our understanding of the utility and significance of inflammation ratios in improving the lives of people with HIV.

show abstract

“…Hence, a complete blood count (CBC) could serve as a biomarker for COVID-19. Screening the COVID-19 infection in terms of CBC has been attempted by various research groups worldwide, 9 10 11 12 13 14 .…”

Section: Introductionmentioning

confidence: 99%

The external validity of machine learning-based prediction scores from hematological parameters of COVID-19: A study using hospital records from Brazil, Italy, and Western Europe

Bandyopadhyay

2023

Preprint

View full text Add to dashboard Cite

Background The COVID-19 pandemic is the deadliest threat to humankind caused by the SARS-COV-2 virus in recent times. The gold standard for its detection, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR), has several limitations regarding experimental handling, expense, and time. While the hematochemical values of routine blood tests have been reported as a faster and cheaper alternative, the external validity of the model on a diverse population has yet to be thoroughly investigated. Here we studied the external validity of machine learning-based prediction scores from hematological parameters recorded in Brazil, Italy, and Western Europe. Methods and Findings The publicly available hematological records (raw sample size (n) = 195554) from hospitals of three different territories, Brazil, Italy, and Western Europe, were preprocessed to develop the training, testing, and prediction cohorts for ML models. A total of eight (sub)datasets were trained on seven different ML classifiers. The XGBoost classifier performed consistently better on all the datasets producing eight different models. The working models include a set of either four or fourteen hematological parameters. The internal performances of the XGBoost models (AUC scores range from 84% to 97%) were superior to the ML models reported in the literature for a few datasets (AUC scores range from 84% to 87%). The external performance (AUC score) was 86% when the model was trained and tested on fourteen hematological parameters obtained from the same country (Brazil) but on independent datasets. However, the external performances were reduced when tested across the populations; 69% when trained on datasets from Italy (n=1736) and tested on datasets from Brazil (n=602)) and 65%, when trained on datasets from Italy and tested on datasets from Western Europe (n=1587)) respectively. Conclusion For the first time, this report showed that the models trained and tested on the same population but on separate records produced reasonably accurate results. The study promises the confidence of these models trained and tested within the same populations and has the potential application to extend those to other demographic locations. Both four- and fourteen-parameter models are publicly available; https://covipred.bits-hyderabad.ac.in/home

show abstract

Hematological findings in adult patients with SARS CoV‐2 infection at Tygerberg Hospital Cape Town South Africa

Cited by 8 publications

References 36 publications

Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná

Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná

Utilization of immunological ratios in HIV: Implications for monitoring and therapeutic strategies

The external validity of machine learning-based prediction scores from hematological parameters of COVID-19: A study using hospital records from Brazil, Italy, and Western Europe

Contact Info

Product

Resources

About