Patient Derived Tumor Xenograft Models 2017
DOI: 10.1016/b978-0-12-804010-2.00027-8
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Patient-Derived Tumor Xenograft

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Cited by 3 publications
(2 citation statements)
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“…The PDX models of colon cancer and brain tumors were successfully generated on our AF and morphologically faithfully recapitulated the original patient tumor after different generations. The PDX model preserves cell interaction and has furthered the understanding of tumor biology, tumor genetic evolution and tumor pathobiology, and shown promise for identifying new biomarkers, as well as offering a tool for developing anticancer therapies and personalized medicine for patients with cancer, and has contributed to the poor outcomes of numerous clinical trials [20,[45][46][47].…”
Section: Discussionmentioning
confidence: 99%
“…The PDX models of colon cancer and brain tumors were successfully generated on our AF and morphologically faithfully recapitulated the original patient tumor after different generations. The PDX model preserves cell interaction and has furthered the understanding of tumor biology, tumor genetic evolution and tumor pathobiology, and shown promise for identifying new biomarkers, as well as offering a tool for developing anticancer therapies and personalized medicine for patients with cancer, and has contributed to the poor outcomes of numerous clinical trials [20,[45][46][47].…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, they are not able to support the development of all human immune cells (including monocytes, macrophages, and natural killer cells), a problem for which exogenous cytokine delivery has been explored as a potential solution. 44 In comparison to these models, genetically engineered mouse (GEM) models make it possible to model the multiple genetic alterations that often accumulate in tumors over time, in addition to the incorporation of oncogenes, the ablation of tumor suppressor genes, and the modeling of hereditary cancer through germ-line mutations. 45 example, to model pancreatic cancer, researchers developed acinar-cell-specific elastase-promoter-driven Kras G12D transgenic mice, which developed preneoplastic ductal lesions consistent with the most common oncogenic RAS mutations found in humans.…”
Section: Patient-derived Xenograft Modelsmentioning
confidence: 99%