Patient-controlled analgesia with fentanil and midazolam in children with postoperative neurosurgical pain

Chiaretti, Antonio; Genovese, Orazio; Antonelli, Alessia; Tortorolo, Luca; Ruggiero, Antonio; Focarelli, Benedetta; Rocco, Concezio Di

doi:10.1007/s00381-007-0429-z

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…Stewart et al reported that the mixed infusion of ondansetron with midazolam and fentanyl was stable for 24 hours [9]. In a study by Chiaretti et al [10], an effective result was achieved without any particular problems when fentanyl and midazolam were mixed and infused into PCA patients. Thus, the authors considered the mixed solution of fentanyl, ondansetron, and midazolam to be safe and physicochemically stable.…”

Section: Methodsmentioning

confidence: 99%

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Kim

Koo

Kang

et al. 2012

Korean J Anesthesiol

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BackgroundWe made a comparative study on the antiemetic effect of midazolam and ondansetron added to intravenous patient-controlled analgesia (PCA) using fentanyl with gynecologic patients undergoing pelviscopic surgery.MethodsThe PCA using 20 µg/kg of fentanyl was started in all groups postoperatively. A dose of 16 mg of ondansetron was added to the PCA of group O (n = 30). A dose of 5 mg of midazolam was added to the PCA of group M (n = 30). While 16 mg of ondansetron and 5 mg of midazolam were added to the PCA of group MO (n = 30). Total volume of the PCA was 60 ml, and the PCA system was programmed to deliver 0.5 ml/h of continuous doses and a 0.5 ml bolus on demand, with a 15 minutes lockout interval. The incidence of postoperative nausea and vomiting (PONV), sedation score, visual analog scale (VAS) for pain, and rescue drug dose for PONV were investigated at the postanesthesia care unit (PACU), 6 hours, and 24 hours after recovery.ResultsThe incidence of PONV in group MO was significantly lower than in group O at PACU, 24 hours after recovery (P < 0.05). The sedation score and VAS pain score showed no differences among all groups.ConclusionsMidazolam added to PCA using fentanyl proved more effective than ondansetron in preventing PONV without adverse effects.

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Section: Methodsmentioning

confidence: 99%

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Kim

Koo

Kang

et al. 2012

Korean J Anesthesiol

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“…Fentanyl PCA has been used safely and effectively following neurosurgery (Chiaretti et al, 2008 Level IV), thoracic surgery (Butkovic et al, 2007 Level III-1) and tonsillectomy (Antila et al, 2006 Level II), and for acute cancer-related pain (Ruggiero et al, 2007 Level IV). In comparison with morphine, tramadol PCA provided minor improvements in time to extubation post cardiac surgery Level II) and reduced nausea post-tonsillectomy but at the cost of higher pain scores (Ozalevli et al, 2005 Level II).…”

Section: The Pca Prescriptionmentioning

confidence: 99%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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“…Çalışmamızda postoperatif analjezide optimal ağrı kontrolü, yüksek hasta-aile mennuniyeti ile beraber güvenli ve efektif bir ağrı yönetimi sağlayan PCA yöntemini tercih ettik (17)(18)(19)(20)(21). PCA da hastanın kendi denetimindeki bolus dozlar sayesinde ağrı kesici ihtiyacı duyduğu zamanla ağrı Şekil1.…”

Section: Discussionunclassified

“…PCA da hastanın kendi denetimindeki bolus dozlar sayesinde ağrı kesici ihtiyacı duyduğu zamanla ağrı Şekil1. Grup 1 ve 2 VAS grafiği kesici uygulanması arasında bekleme süresi olmaması avantajını kullandık (18). Biz bu çalışmada ise postoperatif ağrı değerlendirmesinde sözel iletişim kurabilen ve kavramları gelişen yedi yaş üzeri çocuklarda 0-10 cm arasında VAS skorlaması uyguladık.…”

Section: Discussionunclassified

Tek Taraflı İnguinal Herni Operasyonu Uygulanan Çocuklarda Açık ve Laparoskopik Cerrahi Tekniklerinin Anestezi Süresi, Postoperatif Ağrı ve Analjezik Tüketimi Üzerine Etkilerinin Karşılaştırılması

İnal¹,

Çelebi²,

Uysal³

et al. 2014

Haseki

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Patient-controlled analgesia with fentanil and midazolam in children with postoperative neurosurgical pain

Cited by 17 publications

References 24 publications

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Tek Taraflı İnguinal Herni Operasyonu Uygulanan Çocuklarda Açık ve Laparoskopik Cerrahi Tekniklerinin Anestezi Süresi, Postoperatif Ağrı ve Analjezik Tüketimi Üzerine Etkilerinin Karşılaştırılması

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