The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Kim, Dae Seong; Koo, Gill Hoi; Kang, Hyun; Baek, Chong Wha; Jung, Yong Hun; Woo, Young Cheol; Kim, Jin Yun; Park, Sun Gyoo

doi:10.4097/kjae.2012.62.4.343

Cited by 9 publications

(23 citation statements)

References 31 publications

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“…16 In this study, the incidence of PONV in the group receiving ondansetron and midazolam added to a IV-PCA device containing fentanyl was significantly lower than that observed in the group receiving ondansetron added to the IV-PCA at PACU, 24 h Normally distributed data were analysed using analysis of variance and a post hoc Tukey test; non-normally distributed data were analysed using the Kruskal-Wallis test.…”

Section: Discussionmentioning

confidence: 63%

Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: A prospective, randomized, double-blind study

et al. 2013

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Objective: To compare the efficacy of ramosetron, midazolam, and the combination of ramosetron and midazolam in the prevention of postoperative nausea and vomiting (PONV) in female patients undergoing thyroidectomy. Methods: Patients were randomized to receive 0.3 mg ramosetron (Group R), 75 mg/kg midazolam (Group M) or 0.3 mg ramosetron combined with 75 mg/kg midazolam (Group RM) before the induction of anaesthesia. PONV, use of rescue antiemetics, pain severity and fentanyl consumption were assessed for 24 h after thyroidectomy. Results: A total of 100 patients were enrolled; 94 patients completed the study. The severity of nausea was statistically significantly reduced at 0-2 h in Group RM compared with Groups R and M, and at 2-6 h in Group RM compared with Group M. The incidence of retching and vomiting was significantly lower at 0-2 h, 2-6 h, 6-12 h in Group RM than in Group M, and lower in Group R than Group M at 6-12 h. The requirement for rescue antiemetics was significantly lower at 0-2 h in group RM than in group M. Conclusion: The combination therapy of ramosetron and midazolam provided superior antiemetic efficacy compared with midazolam single therapy, but did not show any significant additional benefits compared with ramosetron single therapy.

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Section: Discussionmentioning

confidence: 63%

Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: A prospective, randomized, double-blind study

et al. 2013

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“…Sedation scores within 3 h postoperatively were significantly lower in the metoclopramide group. On the contrary, Kim et al .,[ 17 ] showed in his trial that sedation scores were not statistically different between the groups. Makhdoom and Farid[ 21 ] compared midazolam 0.075 μg/kg alone or in combination with dexamethasone or dexamethasone alone and found no statistical differences between the groups regarding postoperative drowsiness.…”

Section: Discussionmentioning

confidence: 99%

“…They also found that the incidence of first attack of PONV was lower in group if dose was given before extubation as compared to group using the same premedication dose of midazolam. [ 16 ] Kim et al .,[ 17 ] compared the antiemetic effect of midazolam and/or ondansetron added to intravenous patient-controlled analgesia using fentanyl in gynecologic patients undergoing pelviscopic surgery. He concluded that the incidence of PONV in midazolam-ondansetron group (MO) was significantly lower than in group ondansetron (O) at postanaesthesia care unit, 24 h after recovery ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

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A prospective controlled study to assess the antiemetic effect of midazolam following intragastric balloon insertion

Abdelhamid

Kamel

2014

J Anaesthesiol Clin Pharmacol

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Background and Aims:Obesity is a chronic disease with considerable morbidity and mortality. The intragastric balloon appears attractive for a group of patients who do not respond to medical therapy and who are not surgical candidates. Postoperative nausea and vomiting (PONV) are distressing adverse effects for these patients. Midazolam has been used as an antiemetic, both as a preventive or rescue medication. The study aims at studying effect of combined use of ondansetron and midazolam to decrease the PONV following intragastric balloon insertion.Materials and Methods:The study was conducted on 54 patients presented for intragastric balloon insertion during the period between 1st of January 2012 and 31 December 2012. Patients were randomly allocated into two groups; Ondansetron group and ondansetron/midazolam group. Patients were assessed for the incidence of nausea and vomiting, nausea and vomiting score, degree of sedation and occurrence of adverse effects during the first 24 h after the operation.Results:Incidence of nausea and/or vomiting during the first 24 h postoperatively was 66% in the ondansetron group, while 34.5% among the ondansetron-midazolam group. There was significant reduction of nausea and/or vomiting in the second group. Degree of postoperative sedation was also significantly different between the two groups in the immediate postoperative period and 30min postoperatively.Conclusion:Use of midazolam combined with ondansetron provides significant reduction and therefore better outcome regarding nausea and vomiting following intragastric balloon insertion.

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“…7,8,9,10 Pada beberapa tahun terakhir, midazolam dilaporkan terbukti efektif sebagai profilaksis PONV setelah pembedahan strabismus pada pasien pediatrik, pembedahan bypass kardiopulmonar (CPB), pembedahan abdominal bawah dengan anestesi umum, bedah myringoplasty dan pada pasien pasca bedah yang mendapat patient controlled analgesia (PCA) menggunakan fentanyl. 11,12,13,14,15 Dengan latar belakang diatas dan mengacu pada penelitian sebelumnya maka peneliti ingin mengevaluasi efektivitas pemberian midazolam 35 µg/ kgBB intravena dibandingkan dengan ondansetron 4 mg intravena sebagai pencegahan PONV pada prosedur laparoskopi.…”

Section: Seluruhunclassified

Efektivitas Midazolam Untuk Pencegahan Mual Muntah Pascabedah Pada Prosedur Laparaskopi

Jamiludin

Aaa

2013

JAI b

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Background: All patients undergoing surgery are at risk for experiencing postsurgical nausea and vomiting ( PONV ). The occurrence of PONV be very detrimental symptoms especially after ambulatory surgical procedures and interfere with the process of recovering from anesthesia and surgery to extend treatment time. Laparoscopy is a minimally invasive surgical procedure that accompanied high enough incidence of PONV. Causes high incidence of PONV in surgery laparaskopi caused by the gas used to insuflasi and led to an emphasis on the nervus vagus which has a relationship with vomiting center in medulla oblongata. In addition, other causes such as anesthetic technique, sex, pain, post-operative care and patient demographic data relating to the influence of the occurrence of emesis.We evaluated the grant of midazolam as an agent as well as anti-emetics which anxiolisis also by reducing the synthesis, release and post-synaptic effects of dopamine and adenosine reuptake menhambat, to reduce the input of dopamine and 5 -HT3 against CRTZ and reduce the input from the thalamus directly influence the vomiting center .Methods: Forty-eight patients who will undergo elective surgical procedures laparaskopi randomly divided into two groups. Having given medication premedikasi, group M ( n = 24 ) given midazolam 35 g / kg body weight intravenously; groups O ( n = 24 ) given ondansetron 4 mg intravenously. Procedures for anesthesia, opioid usage and long operation recorded. Then post-surgical nausea, vomiting incident was observed and recorded over a period of 8 hours postoperative. Results:The occurrence of nausea, vomiting after surgical procedures laparoscopic in this study are measured using PONV score with a 30-minute interval during the recovery room and every 1 hour in a treatment room for 8 hours post-surgery. At this done, there is a meaningful difference between the two groups with the result p = 0.022 ( p < 0.05 ) at P2 observation ( 60 minutes post-surgery ).Conclusion: midazolam 35 g / kg body weight after premedikasi on general anesthesia in elective surgical procedures laparaskopi reduce nausea vomiting incident postoperative especially at 1 hour post-surgery. ABSTRAKLatar belakang: Seluruh pasien yang menjalani pembedahan beresiko untuk mengalami mual dan muntah pasca bedah (PONV). Kejadian PONV menjadi gejala yang sangat merugikan terutama setelah prosedur pembedahan ambulatori serta mengganggu proses pemulihan pasca anestesi dan pembedahan sehingga memperpanjang waktu perawatan. Laparoskopi adalah suatu prosedur pembedahan minimal invasif yang disertai insidens PONV cukup tinggi. Penyebab tingginya angka kejadian PONV pada pembedahan laparaskopi disebabkan oleh gas yang digunakan untuk insuflasi dan menyebabkan penekanan pada nervus vagus yang memiliki hubungan dengan pusat muntah di medulla oblongata. Selain itu, penyebab lain seperti teknik anestesi, jenis kelamin, nyeri, perawatan pasca operatif dan data demografik pasien yang berhubungan dengan pengaruh terjadinya emesis.Kami mengevaluasi pemberian midazolam...

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The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Cited by 9 publications

References 31 publications

Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: A prospective, randomized, double-blind study

Ramosetron, midazolam, and combination of ramosetron and midazolam for prevention of postoperative nausea and vomiting: A prospective, randomized, double-blind study

A prospective controlled study to assess the antiemetic effect of midazolam following intragastric balloon insertion

Efektivitas Midazolam Untuk Pencegahan Mual Muntah Pascabedah Pada Prosedur Laparaskopi

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