Patient Compliance and Disease Management in the Treatment of Psoriasis in the Netherlands

Abstract

Background: Compliance behaviour and disease management are important issues in chronic skin diseases. Psoriasis patients are ‘experts by experience’ because of many years of treatment. Therefore, it is relevant to gather data from patients on the actual use of antipsoriatic treatments. Objective: The following questions are addressed: (1) What is the present mode of prescription and actual use of antipsoriatic treatments, including topical treatments, photo(chemo)therapy and systemic treatments? (2) What information do patients expect from their doctor, and do they actually receive this information. Methods: To answer these questions, a questionnaire survey was mailed to the subscribers of Psoriasis, the journal of the Dutch Psoriasis Patients’ Organisation. Results: (1) Major issues in the treatment of psoriasis are (a) long-term management, (b) control of mild, moderate but also extensive psoriasis and (c) control of psoriasis on difficult localisations. Patients perceive itch, scaliness and visibility as major criteria for efficacy. (2) Topical treatment is the mainstay in the management of psoriasis. Calcipotriol is the most prescribed drug. Photo(chemo)therapy has an intermediate position between topical and systemic treatments. UVB is prescribed more than twice as frequently as PUVA and 10% of the patients on photo(chemo)therapy proved to be treated with UVB at home. Only 16% of the patients were on a systemic treatment; methotrexate and acitretin were the most frequently used systemic treatments. (3) More than 70% of the patients indicated that they had taken part in the selection of a treatment. In general, the patients were satisfied about the contact with their dermatologist and general practitioner. Compliance with the duration of treatment is limited, especially with regard to topical treatment. Patient compliance with the dose of the treatment is better. Again compliance is the worst in topical treatments. (4) Patients have a strong preference for an effective treatment which is safe for long-term use. Only a minority of patients wants a fast clearing treatment. Conclusion: Itch, scaliness and visibility provide the most relevant information on the severity of psoriasis, as the patients perceive themselves. Treatment duration is often unrestricted, especially with regard to topical treatments, which implies that the cumulative toxicity potential of these treatments may have a serious impact on their safety profile. Patients regard it of importance to have a vote in the selection of the treatment and regard safety as more important than fast clearing.

Objective Assessment of Compliance With Psoriasis Treatment

“…9,30 Although this consistency is helpful because it indicates the reliability of the data, different methods were used compared with previous studies. 31,32 Objective methods give much lower figures for compliance overall than are achieved by the more subjective method of asking the patient directly about his or her treatment use (interview medication adherence). This demonstrates the unreliability of subjective methods, affected by the desire of patients to appear to have complied with prescribed treatment.…”

Members of the National Psoriasis Foundation

“…18,19 American members were more likely to use systemic therapies such as methotrexate, oral retinoids, or cyclosporine. 18,19 However, in contrast to large differences in absolute use rates, the proportion of members and nonmembers who knew of a therapy and used it was comparable for 9 of 10 therapies (all but UV-B).…”

“…18,19 American members were more likely to use systemic therapies such as methotrexate, oral retinoids, or cyclosporine. 18,19 However, in contrast to large differences in absolute use rates, the proportion of members and nonmembers who knew of a therapy and used it was comparable for 9 of 10 therapies (all but UV-B). This finding suggests that the added knowledge about psoriasis therapies among NPF members increases treatment use by creating greater treatment awareness but may not increase the probability that a person made aware of a therapy will actually use it.…”

Hautpflege bei Psoriasis

“…Regeneration der Hautbarrierefunktion [11] ebenso wichtig wie eine Linderung des häufig empfundenen Juckreizes [1, 5,7]. Es ist vorteilhaft, wenn die …”