Patient and Family Partnership for Safer Health Care

Rees, Philippa; Wimberg, Janet; Walsh, Kathleen E.

doi:10.1542/peds.2017-2847

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…[55] The injectability of gel-forming solutions was measured by using 3 mL syringes and three different needles sizes, which are currently commonly used in medicine: 20 G is intended for intraarticular injections, 25 G and 27 G are intended for intramuscular, intradermal, and subcutaneous injections. [56,57] Three levels of DGF: 0 -20 N, 20 -40 N, and > 40 N are illustrated in Figure 1A. They describe the suitability of tested solutions for injection.…”

Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Toropitsyn

Ščigalková

Pravda

et al. 2023

Macromolecular Bioscience

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Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation of cartilage and synovial fluid (SF). Platelet derivatives as platelet‐rich plasma (PRP) and platelet lysate have great potential in the treatment of osteoarthritis because they contain biologically active substances including growth factors (GFs). Rapid release of GFs and their short biological half‐life are factors that can limit the therapeutic impact of PRP therapy. Herein, the first work that describes hydrogels based on polyaldehyde derivative of hyaluronic acid (HA‐OX) as carriers of platelet derivatives for in situ applications is presented, which can be a possible solution to the problem. HA‐OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(<10 Pa s) and injection force (<20 N), and reach elastic modulus up to 2000 Pa. Insulin‐like GF‐1 and Platelet‐derived GF‐AB release from HA‐OX hydrogels (mesh size 297–406 nm) by Fickian and non‐Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%–92%). Based on the obtained results, the unique concept of a new material that can restore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed.

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Section: Discussionmentioning

confidence: 99%

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Toropitsyn

Ščigalková

Pravda

et al. 2023

Macromolecular Bioscience

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“…Potential lapses in quality due to staff shortages may lead to a chronic culture of burnout, which from our study begins to affect perceptions and possibly worsens matters. Improvements in safety may be achieved through greater collaboration with parents and caregivers who could be encouraged to assist with monitoring quality and safety along with the healthcare team during the hospitalization (Rees, Wimberg, & Walsh, 2018). Indeed, families’ perceptions of the safety culture and risk of adverse events might be an important measure that could be introduced and compared with nurses’ views and other data to both measure and improve clinical practice but also to verify the nurses’ perceptions (Rosenberg et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

A cross‐sectional multisite exploration of Italian paediatric nurses’ reported burnout and its relationship to perceptions of clinical safety and adverse events using the RN4CAST@IT‐Ped

Bagnasco

Dasso

Rossi

et al. 2020

Journal of Advanced Nursing

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To explore Italian paediatric nurses' reported burnout and it relationship to their perceptions of safety and adverse events. DesignA cross-sectional study utilizing the RN4CAST@IT-Ped database using a web based survey design. MethodsThe RN4CAST@IT-Ped questionnaire was used to collect data in 2017. This comprised three main components: three dimensions (22 items) of the Maslach Burnout Inventory including emotional exhaustion, depersonalization and personal accomplishment.Participants also scored an overall grade of patient safety and estimated the occurrence of adverse clinical events. ResultsNurses (n=2243) reported high levels of burnout. Most rated clinical safety highly. The risk of adverse events ranged from 1.3-12.4%. The degree of burnout appeared to influence the perception of safety and adverse events. ConclusionThe association between nurses' burnout and perceptions of higher rates of adverse events and reduced safety in clinical practice is an important finding. However, it is unclear whether this was influenced by a negative state of mind, and whether reduced safety and increased adverse events negatively influenced nurses' well-being, thus leading to burnout. Regardless, the association between nurses' burnout and these quality concepts needs further exploration to examine the effect, if any, on burnout and safety, and identify supportive mechanisms for nurses. Impact:• The association between reported burnout and perception of safety and risk of adverse events in Italian paediatric nurses has been reported for the first time.• Nurses reporting burnout are at greater risk of intensely negative perceptions of clinical safety and adverse events. This is an important finding as perceptions can influence practice and behaviours.• Quality measures in children's clinical environments need to go beyond obvious indicators to examine nurses' well-being as this also influences quality and safety.

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“…In addition, the diverse nature of paediatrics encompassing neonates to adolescents, and the reduced physiological reserve of children, complicates care further 5 6. Despite these vulnerabilities to healthcare-associated harm, children have a unique protective factor in the form of their families, parents and guardians 7…”

Section: Introductionmentioning

confidence: 99%

“…For example, studies from the USA and UK highlight that medication errors in the community setting, such as accidentally administering the wrong dose of a drug, often involve parents 6 8–10. Conversely, parents are well placed to detect errors due to their continuous presence, overview of any care received, and extensive knowledge of the child’s diagnoses and management plans 6–8 11. Khan et al have demonstrated the capability of parents to report errors and highlighted that where parents are permitted to submit safety incident reports, error detection (and reporting) increases and a greater breadth of errors are detected 12.…”

Section: Introductionmentioning

confidence: 99%

Family role in paediatric safety incidents: a retrospective study protocol

Rees,

Purchase,

Ball

et al. 2023

BMJ Open

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IntroductionHealthcare-associated harm is an international public health issue. Children are particularly vulnerable to this with 15%–35% of hospitalised children experiencing harm during medical care. While many factors increase the risk of adverse events, such as children’s dependency on others to recognise illness, children have a unique protective factor in the form of their family, who are often well placed to detect and prevent unsafe care. However, families can also play a key role in the aetiology of unsafe care.We aim to explore the role of families, guardians and parents in paediatric safety incidents, and how this may have changed during the pandemic, to learn how to deliver safer care and codevelop harm prevention strategies across healthcare settings.Methods and analysisThis will be a retrospective study inclusive of an exploratory data analysis and thematic analysis of incident report data from the Learning from Patient Safety Events service (formerly National Reporting and Learning System), using the established PatIent SAfety classification system. Reports will be identified by using specific search terms, such as *parent* and *mother*, to capture narratives with explicit mention of parental involvement, inclusive of family members with parental and informal caregiver responsibilities.Paediatricians and general practitioners will characterise the reports and inter-rater reliability will be assessed. Exploratory descriptive analysis will allow the identification of types of incidents involving parents, contributing factors, harm outcomes and the specific role of the parents including inadvertent contribution to or mitigation of harm.Ethics and disseminationThis study was approved by Cardiff University Research Ethics Committee (SMREC 22/32). Findings will be submitted to a peer-reviewed journal, presented at international conferences and presented at stakeholder workshops.

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Patient and Family Partnership for Safer Health Care

Cited by 6 publications

References 10 publications

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

A cross‐sectional multisite exploration of Italian paediatric nurses’ reported burnout and its relationship to perceptions of clinical safety and adverse events using the RN4CAST@IT‐Ped

Family role in paediatric safety incidents: a retrospective study protocol

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