Pathways leading to an immunological disease: systemic lupus erythematosus

Zharkova, Olga; Celhar, Teja; Cravens, Petra D.; Satterthwaite, Anne B.; Fairhurst, Anna‐Marie; Davis, Laurie S.

doi:10.1093/rheumatology/kew427

Cited by 135 publications

(119 citation statements)

References 155 publications

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“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the loss of immunological tolerance against nuclear antigens [1]. The clinical and paraclinical tools to assess disease activity and predict the disease course are inadequate, and identification of easily accessible biomarkers is required for SLE [2].…”

Section: Introductionmentioning

confidence: 99%

Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus

et al. 2020

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BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by elevated interferon (IFN) signature genes. Galectin-9 (Gal-9) is a β-galactoside-binding lectin that is reportedly useful as a biomarker for IFN gene signatures. In a cross-sectional study of Japanese patients with recent-onset SLE, we aimed to determine whether raised serum Gal-9 levels were associated with the disease activity or organ damage seen in SLE patients. OPEN ACCESS Citation: Matsuoka N, Fujita Y, Temmoku J, Furuya MY, Asano T, Sato S, et al. (2020) Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus. PLoS ONE 15(1): e0227069. Methods Patients and clinical evaluationsA total of 58 Japanese patients with recent-onset SLE were included in the study. SLE patients were enrolled within 32 months (mean 18 month, range 0-32) of SLE diagnosis, which was Galectin-9 and lupus disease activity PLOS ONE | https://doi.

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Section: Introductionmentioning

confidence: 99%

Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus

et al. 2020

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“…This action favors the probability of presentation of self-antigens. 174 Mice with SLE in which DCs are extracted present a decreased disease activity, in addition to a decrease in the number of regulatory and inflammatory T cells. So it was shown that in SLE, the DCs are not required for initial activation of T cells and B cells; however, they do promote their proliferation and are essential in the progression of tissue damage.…”

Section: Dendritic Cellsmentioning

confidence: 99%

Rheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system

et al. 2019

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Rheumatoid arthritis and systemic lupus erythematosus are two highly prevalent autoimmune diseases that generate disability and low quality of life. The innate immune system, a long-forgotten issue in autoimmune diseases, is becoming increasingly important and represents a new focus for the treatment of these entities. This review highlights the role that innate immune system plays in the pathophysiology of rheumatoid arthritis and systemic lupus erythematosus. The role of the innate immune system in rheumatoid arthritis and systemic lupus erythematosus pathophysiology is not only important in early stages but is essential to maintain the immune response and to allow disease progression. In rheumatoid arthritis, genetic and environmental factors are involved in the initial stimulation of the innate immune response in which macrophages are the main participants, as well as fibroblast-like synoviocytes. In systemic lupus erythematosus, all the cells contribute to the inflammatory response, but the complement system is the major effector of the inflammatory process. Detecting alterations in the normal function of these cells, besides its contribution to the understanding of the pathophysiology of autoimmune diseases, could help to establish new treatment strategies for these diseases.

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“…The disease prevalence rate estimated about 5 million people worldwide and it occurs mostly before age 45 years [3][4][5]. The loss of central and peripheral tolerance to self is proposed to be a crucial first step in the progress of SLE [6]. The autoimmunity can be provoked in genetically susceptible individuals by some environmental triggers like hormones (eight times higher in women), infections (microbes, virus …), ultraviolet light, toxins and etc.…”

Section: Introductionmentioning

confidence: 99%

An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus

Maleknia

Salehi

Sharifi‐Zarchi

et al. 2020

Preprint

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Background: To perceive a comprehensive illustration of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, draw a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics algorithms to discover the unknown aspects. This study aimed to distinguish key molecular characteristics of SLE pathogenesis, which may serve as effective targets for therapeutic intervention. Methods: In the present study, six gene expression microarray datasets included SLE patients (n=220) and healthy controls (n=135) were collected. We integrated the datasets by cross-platform normalization. Subsequently, through BNrich method, the structures of Bayesian networks (BNs) were extracted from SLE, TCR and BCR signaling pathways and the parameters of BNs were estimated using integrated datasets. Finally, a meta-analysis was performed to distinguish the signaling pathways alterations in the SLE pathogenesis. Results: We identified the most dysregulated genes involved in the clearance mechanism (most inhibition in MACROH2A2 and H4C9, most activation in SNRPD3, MACROH2A1 and RO60). Augmented autoantigens presentation by MHCII (HLA-DQA1, HLA-DOB and HLA-DPB1) and CD80 and CD86 to CD28 biological functions were also observed. The increased expression of FCGR1A, C8G, C7 and C9 genes and decreasing biological functions in edges from C1R and C1S to C2 and from C1R to C4B, all involved in end-organ damage, were detected. On the other hand, many of subnetworks alterations of TCR and BCR reported in previous research (PI3K/AKT, MAPK, AP-1 transcription factor). Conclusions: Overall, the BNrich as a hybridized network construction method, which integrates intergenic relations inferred from signaling pathways and gene expression profiling, can be employed to study complex diseases. Here we applied BNrich and highlighted significant genes and intergenic relationships and systemic alterations in SLE, TCR and BCR signaling pathways.

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Pathways leading to an immunological disease: systemic lupus erythematosus

Cited by 135 publications

References 155 publications

Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus

Galectin-9 as a biomarker for disease activity in systemic lupus erythematosus

Rheumatoid arthritis and systemic lupus erythematosus: Pathophysiological mechanisms related to innate immune system

An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus

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