Pathotypic and Sequence Characterization of Newcastle Disease Viruses from Vaccinated Chickens Reveals Circulation of Genotype II, IV and XIII and in India

Jakhesara, Subhash J.; Prasad, V.V.S.P.; Pal, J. K.; Jhala, M. K.; Prajapati, K. S.; Joshi, Chaitanya G.

doi:10.1111/tbed.12294

Cited by 26 publications

(16 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2013 (Khan et al, 2010;Munir et al, 2012a;Shabbir et al, 2013;Jakhesara et al, 2014;Gogoi et al, 2015). Viruses have been isolated from chickens with the exception of a single virus strain recovered from Japanese quail (Coturnix coturnix japonica) in India in 2003 .…”

Section: Sub-genotype Xiiib Viruses Have Been Recovered From India Anmentioning

confidence: 99%

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Dimitrov

Ramey

Qiu

et al. 2016

Infection, Genetics and Evolution

229

227

View full text Add to dashboard Cite

Newcastle disease is caused by virulent forms of avian paramyxovirus of serotype 1 (APMV-1) and has global economic importance. The disease reached panzootic proportions within two decades after first being identified in 1926 in the United Kingdom and Indonesia and still remains endemic in many countries across the world. Here we review information on the host, temporal, and geographic distribution of APMV-1 genetic diversity based on the evolutionary systematics of the complete coding region of the fusion gene. Strains of APMV-1 are phylogenetically separated into two classes (class I and class II) and further classified into genotypes based on genetic differences. Class I viruses are genetically less diverse, generally present in wild waterfowl, and are of low virulence. Class II viruses are genetically and phenotypically more diverse, frequently isolated from poultry with occasional spillovers into wild birds, and exhibit a wider range of virulence. Waterfowl, cormorants, and pigeons are natural reservoirs of all APMV-1 pathotypes, except viscerotropic velogenic viruses for which natural reservoirs have not been identified. Genotypes I and II within class II include isolates of high and low virulence, the latter often being used as vaccines. Viruses of genotypes III and IX that emerged decades ago are now isolated rarely, but may be found in domestic and wild birds in China. Containing only virulent viruses and responsible for the majority of recent outbreaks in poultry and wild birds, viruses from genotypes V, VI, and VII, are highly mobile and have been isolated on different continents. Conversely, virulent viruses of genotypes XI (Madagascar), XIII (mainly Southwest Asia), XVI (North America) and XIV, XVII and XVIII (Africa) appear to have a more limited geographic distribution and have been isolated predominantly from poultry.

show abstract

Section: Sub-genotype Xiiib Viruses Have Been Recovered From India Anmentioning

confidence: 99%

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Dimitrov

Ramey

Qiu

et al. 2016

Infection, Genetics and Evolution

229

227

View full text Add to dashboard Cite

show abstract

“…4,5 In India, vaccination failures can be attributed mainly to lower vaccine quality, inappropriate vaccination process and dose, antigenically variant strains and evolution of virulent strains influenced by vaccine pressure and positive selection. [5][6][7][8] Among all listed issues of vaccine failures, antigenic variation in circulating strains is the most challenging. 6,9,10 Based on genetic variation and phylogenetic analysis among all isolates, NDV strains are categorized into XVI genotypes and two classes.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] Among all listed issues of vaccine failures, antigenic variation in circulating strains is the most challenging. 6,9,10 Based on genetic variation and phylogenetic analysis among all isolates, NDV strains are categorized into XVI genotypes and two classes. Class 1 comprises of genotype I NDV strains, while class 2 contains genotypes II to XVI.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of an apoptotic strain of Newcastle disease virus isolated from an outbreak in India

Kumar

2015

Cancer Gene Ther

View full text Add to dashboard Cite

Newcastle disease (ND) is a highly contagious disease of poultry. The ND virus (NDV) encodes an error-prone RNA-dependent RNA polymerase which can cause high mutation rate leading to the emergence of its new antigenic variants. Antigenic difference of NDV strains may result in massive outbreak in vaccinated and unvaccinated poultry flocks around the globe. Apart from its pathogenic potential NDV has been explored as an oncolytic agent for a broad range of human cancers. In the present study, we isolated a novel NDV strain from an outbreak in chicken flock from the eastern part of India. Molecular characterization showed the NDV strain to be virulent in nature. The complete genome sequence analysis of the newly isolated strains belongs to genotype XIII. Moreover, the newly isolated strain of NDV showed positive results in various apoptotic assays in human breast cancer cells, MCF-7. The study will be useful to explore the possibility of using a newly isolated strain of NDV for virotherapy.

show abstract

“…A range of random amplification methods coupled with Next Generation Sequencing platforms, such as Roche-454 [ 32 ], Illumina HiSeq [ 33 ], and Ion Torrent PGM [ 34 ], have been recently used to discover unexpected and unknown viruses. However, plasmid cloning and Sanger sequencing remains still as a practical alternative for the rapid identification of viruses in clinical samples.…”

Section: Discussionmentioning

confidence: 99%

Identification and Genome Characterization of the First Sicinivirus Isolate from Chickens in Mainland China by Using Viral Metagenomics

et al. 2015

View full text Add to dashboard Cite

Unlike traditional virus isolation and sequencing approaches, sequence-independent amplification based viral metagenomics technique allows one to discover unexpected or novel viruses efficiently while bypassing culturing step. Here we report the discovery of the first Sicinivirus isolate (designated as strain JSY) of picornaviruses from commercial layer chickens in mainland China by using a viral metagenomics technique. This Sicinivirus isolate, which contains a whole genome of 9,797 nucleotides (nt) excluding the poly(A) tail, possesses one of the largest picornavirus genome so far reported, but only shares 88.83% and 82.78% of amino acid sequence identity to that of ChPV1 100C (KF979332) and Sicinivirus 1 strain UCC001 (NC_023861), respectively. The complete 939 nt 5′UTR of the isolate strain contains at least twelve stem-loop domains (A–L), representing the highest set of loops reported within Sicinivirus genus. The conserved 'barbell-like' structure was also present in the 272 nt 3′UTR of the isolate as that in the 3′ UTR of Sicinivirus 1 strain UCC001. The 8,586 nt large open reading frame encodes a 2,862 amino acids polyprotein precursor. Moreover, Sicinivirus infection might be widely present in commercial chicken farms in Yancheng region of the Jiangsu Province as evidenced by all the tested stool samples from three different farms being positive (17/17) for Sicinivirus detection. This is the first report on identification of Sicinivirus in commercial layer chickens with a severe clinical disease in mainland China, however, further studies are needed to evaluate the pathogenic potential of this picornavirus in chickens.

show abstract

Pathotypic and Sequence Characterization of Newcastle Disease Viruses from Vaccinated Chickens Reveals Circulation of Genotype II, IV and XIII and in India

Cited by 26 publications

References 53 publications

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Temporal, geographic, and host distribution of avian paramyxovirus 1 (Newcastle disease virus)

Molecular characterization of an apoptotic strain of Newcastle disease virus isolated from an outbreak in India

Identification and Genome Characterization of the First Sicinivirus Isolate from Chickens in Mainland China by Using Viral Metagenomics

Contact Info

Product

Resources

About