Pathophysiology of STZ-induced pancreatic β cell injury and dysfunction: traditional role of Boswellia ovalifoliolata Bal. &amp; Henry on diabetes and dyslipidemia

Konda, Prabhakar Yellanur; Nagalapuram, Ramya; Venkateswarlu, Jyothi Kumar Malaka; Mohammad, Subhan Ali; Chippada, Appa Rao

doi:10.1007/s00580-020-03096-x

Cited by 4 publications

(4 citation statements)

References 40 publications

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“…This chemical induction leads to various manifestations indicative of diabetic nephropathy. Hyperglycemia ensues from disrupted insulin production, a hallmark of diabetes that fuels the progression of nephropathy . Glomerular dysfunction, reflected in altered filtration rates and permeabilities, emerges as an early sign.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperglycemia ensues from disrupted insulin production, a hallmark of diabetes that fuels the progression of nephropathy. 39 Glomerular dysfunction, reflected in altered filtration rates and permeabilities, emerges as an early sign. Oxidative stress, indicated by increased reactive oxygen species and diminished antioxidant defenses, contributes to renal damage.…”

Section: Discussionmentioning

confidence: 99%

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Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats

Ajiboye,

Famusiwa,

Nifemi

et al. 2024

ACS Omega

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Diabetes-induced kidney damage represents a substantial health hazard, emphasizing the imperative to explore potential therapeutic interventions. This study investigates the nephroprotective activity of flavonoid-rich extracts from Hibiscus sabdariffa leaves in streptozotocin-induced diabetic rats. The flavonoid-rich extracts of H. sabdariffa leaves was obtained using a standard procedure. The animals were induced with streptozotocin and thereafter treated with both low (LDHSFL) and high doses (HDHSFL) of flavonoid-rich extracts from H. sabdariffa leaves and metformin (MET), and other groups are diabetic control (DC) and normal control (NC). The study assesses diverse renal parameters, encompassing kidney redox stress biomarkers, serum electrolyte levels, kidney inflammatory biomarkers, serum concentrations of creatinine, urea, and uric acid, kidney phosphatase activities, renal histopathology, and relative gene expressions of kidney injury molecule-1 (KIM-1) and transforming growth factor beta-1 (TGF-1β), comparing these measurements with normal and diabetic control groups (NC and DC). The findings indicate that the use of extracts from H. sabdariffa leaves markedly (p < 0.05) enhanced renal well-being by mitigating nephropathy, as demonstrated through the adjustment of various biochemical and gene expression biomarkers, indicating a pronounced antioxidative and anti-inflammatory effect, improved kidney morphology, and mitigation of renal dysfunction. These findings suggest that H. sabdariffa leaf flavonoid extracts exhibit nephroprotective properties, presenting a potential natural therapeutic approach for the treatment of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats

Ajiboye,

Famusiwa,

Nifemi

et al. 2024

ACS Omega

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“…[45] STZ is a nitrosourea substance that selectively destroys β cells of the pancreas and causes a defect in insulin release leading to hyperglycemia as a distinctive feature of diabetes. [46] Despite the prolonged state of hyperglycemia, the tissues consumption of glucose is confined due to the insulin deficiency that activates the gluconeogenic pathway [47] and enhances the formation of glycation end-products [48] that assumed to be the primary factor of diabetic comorbidities. In the current investigation, remediation of rats with diabetes by different doses of UMB exhibited a remarkable decrease in the glucose levels along with a corresponding elevation in insulin levels and insulin action as explicated by a marked decline in HOMA-IR, as an indicator for insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats

Khadrawy

Sayed

2023

J Biochem & Molecular Tox

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Umbelliferone (UMB), 7‐hydroxycoumarin, is a naturally occurring coumarin derivative that has a plethora of biological and therapeutic activities. The focus of this research was to elucidate the curative effects of two different doses of UMB on diabetic cardiomyopathy (DCM) in a type 2 diabetic rat model induced by 50 mg/kg body weight of streptozotocin (STZ). Diabetic rats orally received 10 or 30 mg/kg of UMB daily for 8 weeks. Compared to the nontreated diabetic group, both UMB treatment doses significantly decreased glucose levels, glycated hemoglobin (HbA1c), tumor necrosis factor alpha (TNF‐α), interleukin‐6 (IL‐6), creatine kinase MB (CK‐MB), cardiovascular risk indices, and oxidative stress by reducing malondialdehyde (MDA) and increasing the activity of the antioxidant enzymes. The hypercholesterolemia and hypertriglyceridemia also dramatically decreased in diabetic groups with UMB treatments accompanied by an improvement in insulin, and insulin sensitivity indices (HOMA‐IR and QUICKI). Furthermore, the cardiac gene expressions and protein levels of Janus kinase2 (JAK2), signal transducer and activator of transcription3 (STAT3), and transforming growth factor beta1 (TGF‐β1) were also markedly downregulated in a dose‐dependent manner by UMB treatments. Finally, the biochemical results were assured by the reduction of histological alterations in cardiac tissues. In conclusion, UMB is a propitious substance for the treatment of DCM by virtuousness of its antihyperglycemic, antihyperlipidemic, antioxidant, and anti‐inflammatory properties through modulating the JAK/STAT signaling pathway that may be the underlying mechanism in UMB action.

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Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus

Kim

Semple

Simpson

et al. 2020

Plant Foods Hum Nutr

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Pathophysiology of STZ-induced pancreatic β cell injury and dysfunction: traditional role of Boswellia ovalifoliolata Bal. & Henry on diabetes and dyslipidemia

Cited by 4 publications

References 40 publications

Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats

Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats

Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats

Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus

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