Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia

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“…This aforesaid results came in agreement with other reports [1,14,15]. Previous studies demonstrated that the reduced absorption of Na + is due to the loss of the absorptive power of the intestinal epithelium [16,17]. In contrast, Ayaz, et al [18] reported that K and Na levels didn't significantly alter in animals infected with many endoparasites.…”

Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

“…As discussed previously, malabsorption of electrolytes, nutrients and water, in association with brush border injury, are responsible for the diarrheal symptoms seen in giardiasis (Buret et al 1992). Numerous reports have also established that infections with Giardia significantly impair digestive enzyme function (Table).…”

“…Together these observations imply a protective function for T-cells in giardiasis, as well as a role for T-cells in the pathogenesis of intestinal villus injury. In the absence of villus atrophy, it is the ultrastructural loss of brush border microvilli that represent the limiting factor to absorption and digestion in a number of intestinal disorders , Buret et al 1992, Farthing 1993. Recent findings indicate that in giardiasis this brush border injury and malfunction are mediated by CD8 + T lymphocytes (Scott et al 2004).…”

SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis

“…Studies in human patients, in experimental animal models, or in cell culture systems, have established that the infection causes small intestinal structural and functional abnormalities. These may include apoptosis induced epithelial barrier defects, microvillous shortening, disaccharidase deficiencies, hypersecretion of chloride, as well as malabsorption of electrolytes and water associated with infiltration of intraepithelial lymphocytes ( [Belosevic et al, 1989], [Buret et al, 1992], [Scott et al, 2000], , [Scott et al, 2004], [Troeger et al, 2007] and [Panaro et al, 2007]). …”