Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

Ag, Buret

doi:10.1590/s0074-02762005000900032

Cited by 12 publications

(6 citation statements)

References 49 publications

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“…However, on the 15 th dPI, improvement in villous architecture was noticed with clearance of Giardia trophozoites. This was in accordance with Buret [50], who detected also increased intestinal disacharidase activity and decreased intraepithelial lymphocytes. Buret [51] also added that shortening of the microvilli could aggravate the deficiency in enzymatic and absorptive capability of enterocytes.…”

Section: Discussionsupporting

confidence: 92%

Efficacy of olibanum and propolis medicinal extracts versus metronidazole in Giardia lamblia experimentally infected mice

Al-Ghandour

Ahmed

Salem

et al. 2020

Microbes and Infectious Diseases

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Section: Discussionsupporting

confidence: 92%

Efficacy of olibanum and propolis medicinal extracts versus metronidazole in Giardia lamblia experimentally infected mice

Al-Ghandour

Ahmed

Salem

et al. 2020

Microbes and Infectious Diseases

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“…IFN-γ stimulates the production of high levels of nitric oxide and frequently acts in concert with other cytokines, such as TNF-α (Nacy et al, 1991). The results of the histopathological examination of the intestinal mucosa of the infected non-treated group are in agreement with multiple studies (Buret, 2005;Abdel-Fattah and Nada, 2007;Abdalla et al, 2011;Fathy, 2011;Mahmoud et al, 2014;Ismail et al, 2017). Numerous host factors, in addition to the interaction between trophozoites and the intestinal epithelium, were responsible for the microvillus changes and epithelial barrier dysfunction observed in the case of giardiasis (Scott et al, 2000;Chin et al, 2002).…”

Section: Introductionsupporting

confidence: 85%

Anti-Giardiasis Effect of Zingiber Officinale on Giardia Lamblia Infection and the Immunological Response in Experimentally Infected Immunocompetent Mice

Almohawes

2019

Journal of the Egyptian Society of Parasitology

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Giardia lamblia is a common protozoan parasite infects humans and is the most common cause of waterborne outbreaks of diarrhoeal diseases. The present study examined the anti-giardiasis effectiveness of ginger as a natural product in the prevention and treatment of G. lamblia in infected mice. Male albino mice were divided into the following four groups: 1. Control uninfected untreated, 2. Infected with Giardia cysts and untreated, 3. Prophylactic with ginger before infection, and 4. Treated with ginger after infection. The results showed that Ginger resulted in a complete eradication of Giardia cysts in the faeces after infection by day 12 in the protected group and day 10 in the treated group. IFN-γ levels were significantly decreased (p<0.05) in the ginger-protected and ginger-treated groups, and IL-5 levels were elevated in both ginger groups. Histopathological observations of the ileum support the immunological findings

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“…The mechanisms responsible for diarrhea in giardiasis are less well understood: no toxins have been clearly identified, and the diarrhea results from malabsorption, not secretion (3,9,11). Enteric infections typically affect intestinal motility patterns by altering neuronal reflex pathways and smooth muscle responses to stimulation (2,23).…”

Section: Discussionmentioning

confidence: 99%

Mast Cell-Mediated Changes in Smooth Muscle Contractility during Mouse Giardiasis

Zhao

Shea‐Donohue

et al. 2007

Infect Immun

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Giardia intestinalis is a significant cause of diarrheal disease worldwide. Infections in animal models have been shown to cause changes in gastrointestinal transit that depend on adaptive immune responses and are mediated, in part, through neuronal nitric oxide synthase. Nitric oxide is an inhibitory neurotransmitter, and we therefore investigated potential excitatory pathways that might be involved in the response to Giardia infection. Infected mice exhibited increased spontaneous and cholecystokinin (CCK)-induced contractions of longitudinal smooth muscle. In contrast, enhanced contractile responses were not observed in response to acetylcholine, 5-hydroxytryptamine, or the protease-activated receptor-1 agonist peptide TFFLR. Giardiainduced changes in smooth muscle function appear to be mediated primarily by mast cells, as both spontaneous and CCK-induced contractions were blocked by pretreatment with either ketotifen or compound 48/80. Together, these data support a model in which CCK release triggers mast cell degranulation, leading to increases in smooth muscle contractility. These contractions, coupled with nitric oxide-mediated muscle relaxation, promote intestinal transit and parasite elimination.

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Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

Abstract: T lymphocyte-mediated pathogenesis is common to a variety of enteropathies, including giardiasis

Cited by 12 publications

References 49 publications

Efficacy of olibanum and propolis medicinal extracts versus metronidazole in Giardia lamblia experimentally infected mice

Efficacy of olibanum and propolis medicinal extracts versus metronidazole in Giardia lamblia experimentally infected mice

Anti-Giardiasis Effect of Zingiber Officinale on Giardia Lamblia Infection and the Immunological Response in Experimentally Infected Immunocompetent Mice

Mast Cell-Mediated Changes in Smooth Muscle Contractility during Mouse Giardiasis

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