Pathophysiology of esophageal impairment due to button battery ingestion

Völker, Johannes; Völker, Christine; Schendzielorz, Philipp; Schraven, Sebastian P.; Radeloff, Andreas; Mlynski, Robert; Hagen, Rudolf; Rak, Kristen

doi:10.1016/j.ijporl.2017.06.030

Cited by 47 publications

(45 citation statements)

References 13 publications

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“…Carafate® crosslinks in acidic environments, forming a paste‐like material . This might be possible in the focal acidic microenvironments that develop near the cathode, allowing Carafate® to enhance its barrier function and slow electrical conduction . Furthermore, Carafate® is negatively charged and binds to positively charged proteins and extracellular matrix components exposed in ulcerated tissue, protecting it from further injury…”

Section: Discussionmentioning

confidence: 99%

“…8 This might be possible in the focal acidic microenvironments that develop near the cathode, allowing Carafate V R to enhance its barrier function and slow electrical conduction. 9 Furthermore, Carafate V R is negatively charged and binds to positively charged proteins and extracellular matrix components exposed in ulcerated tissue, protecting it from further injury. 10 Complications are more likely to occur when nothing is done to mitigate a BB ingestion prior to its removal, as demonstrated by the gross and histological analysis.…”

Section: Discussionmentioning

confidence: 99%

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pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

et al. 2018

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“…According to a recent study (8), button battery induces esophageal injury in two steps: (1) battery discharges within the esophageal electrolyte environment, and (2) creates a strongly alkaline environment in the esophagus. Battery discharge, which induces significant hydroxide accumulation around the negative electrode, is the major cause of esophageal injuries (8,16). Higher discharge happens in a stronger electrolytic environment; lower discharge happens in a weaker electrolytic environment (e.g., acetic acid); while no discharge happens in a nonelectrolytic environment (e.g., oil).…”

Section: Discussionmentioning

confidence: 99%

Edible Oils Attenuate Button Battery-Induced Injury in Porcine Esophageal Segments

Jia

Zhang

et al. 2020

Front. Pediatr.

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Objective: The objective of the study is to test whether the use of edible oil might be an early treatment strategy for reducing button battery-induced esophageal injury.Methods: A button battery was inserted into esophageal segments collected from pigs. The esophageal segments were randomly allotted to one of the following six treatments:(1) untreated (nothing injected), (2) lemon juice, (3) orange juice, (4) colza oil, (5) peanut oil, and (6) olive oil. Every hour, the battery discharge and the pH value were measured in the esophageal tissue. After treatment for 6 h, the residual voltage of the battery was measured and the esophageal tissue was processed with H&E staining.Results: In esophageal segments of the untreated group, a large area of the mucous membrane was severely eroded. Partial erosion was observed in esophageal tissues treated with either lemon juice or orange juice. Furthermore, the esophageal tissues were basically intact, had little damage when treated with oils. The highest extra-esophageal discharge voltage was recorded in the untreated group, a medium amount of discharge voltage was recorded in the lemon juice and orange juice groups, and the lowest discharge voltage was recorded in all the edible oils groups.Conclusions: Edible oils immersed the battery, reduced the surrounding electrolysis, and thus attenuated battery discharge. As a result, treatment with edible oils attenuated the pH alkalization and tissue damage in button battery injury of pig esophageal segments. These results indicate that edible oils might be used in the treatment of button battery ingestion.

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“…Among all the foreign bodies, button battery could be most hazardous, as it can dispense its charge causing liquefactive necrosis of the surface in contact 4. The resultant damage could at times be fatal, depending on the site of lodgement 3.…”

Section: Discussionmentioning

confidence: 99%

Usual suspects: the foreign bodies of the aerodigestive tract

Devaraja¹,

Nayak

Bhandarkar

et al. 2018

BMJ Case Reports

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This case series is about four different foreign bodies lodged in different locations of the aerodigestive tract. All four cases had delayed diagnosis due to inconspicuous history. Radiology in the form of computed tomography aided the appropriate diagnosis in most of these cases. Though all four patients have been successfully managed by removal of foreign body, not all of them have identical outcomes. A brief discussion about predictive factors in the fish bone foreign body has been included. The authors also discuss certain critical aspects of the management, which may aid in reducing the morbidity. We emphasise on the high index of suspicion in peculiar cases and on the low threshold for radiological investigation in doubtful clinical scenarios.

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Pathophysiology of esophageal impairment due to button battery ingestion

Cited by 47 publications

References 13 publications

pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

Edible Oils Attenuate Button Battery-Induced Injury in Porcine Esophageal Segments

Usual suspects: the foreign bodies of the aerodigestive tract

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