Pathophysiology of Bleeding in Surgery

Facchini, Luca; Pedrazzi, Patrizia; Busani, Stefano; Torelli, Giuseppe

doi:10.1016/j.transproceed.2006.01.047

Cited by 106 publications

(85 citation statements)

References 10 publications

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“…Surgeons were blinded for the allocated groups. The CVP at the beginning of the parenchymal transsection was significantly lower in the group with blood withdrawal (median 5 [range [2][3][4][5][6][7][8][9] 40-660] mL, P 5 .034). However, the two showed no statistical difference in postoperative outcomes.…”

Section: Anesthesiologic Strategies To Reduce Blood Lossmentioning

confidence: 95%

“…12,13 The main progress in reducing perioperative blood loss has been made through improved surgical and anesthetic techniques and through better understanding of hemostatic disorders in patients who have liver disease. 7,14 The purpose of this article is to provide a clinically oriented guide to the prevention and treatment of bleeding in liver surgery. The authors discuss the developments in surgical, anesthesiologic, and pharmacologic strategies that have contributed to a reduction of blood loss during liver surgery in cirrhotic and noncirrhotic patients.…”

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confidence: 99%

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Bleeding in Liver Surgery: Prevention and Treatment

Alkozai

Lisman

Porte

2009

Clinics in Liver Disease

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Section: Anesthesiologic Strategies To Reduce Blood Lossmentioning

confidence: 95%

mentioning

confidence: 99%

Bleeding in Liver Surgery: Prevention and Treatment

Alkozai

Lisman

Porte

2009

Clinics in Liver Disease

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“…59 -62 Bleeding is similar with off-pump CABG and on-pump CABG. 63 Five percent to 7% of patients lose Ͼ2 L of blood within the first 24 hours after surgery, 64 and up to 5% require reintervention for bleeding after sternotomy closure. 65 Both surgical re-exploration and red blood cell transfusion are associated in a dose-dependent and often durable manner with prolonged intensive care and hospital stays and reduced survival rates.…”

Section: Special Considerations For Coronary Artery Bypass Graft-relamentioning

confidence: 99%

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

et al. 2011

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A dvances in antithrombotic therapy, along with an early invasive strategy, have reduced the incidence of recurrent ischemic events and death in patients with acute coronary syndromes (ACS; unstable angina, non-ST-segment-elevation myocardial infarction [MI], and ST-segment-elevation MI). [1][2][3][4] However, the combination of multiple pharmacotherapies, including aspirin, platelet P2Y 12 inhibitors, heparin plus glycoprotein IIb/IIIa inhibitors, direct thrombin inhibitors, and the increasing use of invasive procedures, has also been associated with an increased risk of bleeding.

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“…Most bleeding associated with surgical procedures is due to poor surgical hemostasis, also known as "silk deficiency" [15]. However, patients with cancer may also have other factors that contribute to significant perioperative bleeding.…”

Section: Why Cancer Patients May Bleedmentioning

confidence: 99%

Blood Loss and Massive Transfusion in Patients Undergoing Major Oncological Surgery: What Do We Know?

Cata

Gottumukkala

2012

ISRN Anesthesiology

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Patients with solid malignancies who were not candidates for tumor resections in the past are now presenting for extensive oncological resections. Cancer patients are at risk for thromboembolic complications due to an underlying hypercoagulable state; however, some patients may have an increased risk for bleeding due to the effects of chemotherapy, the administration of anticoagulant drugs, tumor-related fibrinolysis, tumor location, tumor vascularity, and extent of disease. A common potential complication of all complex oncological surgeries is massive intra-and postoperative hemorrhage and the subsequent risk for massive blood transfusion. This can be anticipated or unexpected. Several surgical and anesthesia interventions including preoperative tumor embolization, major vessel occlusion, hemodynamic manipulation, and perioperative antifibrinolytic therapy have been used to prevent or control blood loss with varying success. The exact incidence of massive blood transfusion in oncological surgery is largely unknown and/or underreported. The current literature mostly consists of purely descriptive observational studies. Thus, recommendation regarding specific perioperative intervention cannot be made at this point, and more research is warranted.

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Pathophysiology of Bleeding in Surgery

Cited by 106 publications

References 10 publications

Bleeding in Liver Surgery: Prevention and Treatment

Bleeding in Liver Surgery: Prevention and Treatment

Standardized Bleeding Definitions for Cardiovascular Clinical Trials

Blood Loss and Massive Transfusion in Patients Undergoing Major Oncological Surgery: What Do We Know?

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