Pathophysiology in Diabetic Patients with Fecal Incontinence

Watanabe, Makoto; Tsunoda, Akira; Kamiyama, Goichi; Hirano, Tsutomu; Kusano, Mitsuo

doi:10.15369/sujms1989.15.21

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…26,29 Parks et al 30 demonstrated that there was histologic evidence of denervation in the external anal sphincter muscle in patients with fecal incontinence and rectal prolapse, and suggested that this may be the result from pudendal neuropathy occurring as a consequence of rectal descent induced during repeated defecation straining. 32 The present series also showed the increased PNTML in patients with rectal prolapse, even if PNTML was measured only in eight patients compared with that in the control subjects (median, 2.0 ms [1.8-2.2]) reported in our previous study, 33 suggesting that pudendal neuropathy may occur in those patients. 31,32 Similarly, PNTML was significantly increased in incontinent patients with rectal prolapse.…”

Section: Discussionsupporting

confidence: 73%

Delorme's Procedure for Rectal Prolapse

Tsunoda

Yasuda²,

Yokoyama³

et al. 2003

Diseases of the Colon &Amp; Rectum

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Section: Discussionsupporting

confidence: 73%

Delorme's Procedure for Rectal Prolapse

Tsunoda

Yasuda²,

Yokoyama³

et al. 2003

Diseases of the Colon &Amp; Rectum

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“…The pudendal nerves, on the other hand, are somatic nerves that innervate the EAS. Diabetic pudendal neuropathy leads to delay of pudendal nerve terminal motor latency, causes EAS damage, and may result in FI [28]. Our results suggest that somatic neuropathy plays a more important role in FI in diabetic patients.…”

Section: Open Accessmentioning

confidence: 58%

Risk factors for internal anal sphincter dysfunction in Japanese adults

Abé¹,

Kono²,

Hachiro³

et al. 2013

OJGas

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Purpose: The internal anal sphincter provides most of the resting anal tone and is the main muscle responseble for continence. This study was designed to estimate the prevalence of, and identify risk factors associated with, internal anal sphincter dysfunction in Japanese adults. Methods: Anorectal manometry was performed in 1193 women and 1124 men aged 20 years or older. The maximal resting pressure, measured by a rapid pull-through technique, was defined as the highest resting pressure recorded. Internal anal sphincter dysfunction was defined as a maximal resting pressure less than 30 mmHg. Potential risk factors were assessed through self-reports, interviews, physical examinations, and medical record reviews. Multivariate logistic regression analysis was used to identify independent risk factors for internal anal sphincter dysfunction. Results: Significant differences in maximal resting pressure were seen between women (58.1 ± 24.9 mmHg) and men (68.8 ± 23.5 mmHg, P < 0.001). Maximal resting pressure decreased significantly with increasing age in both sexes. The prevalence of internal anal sphincter dysfunction was 10.4% (15.5% in women, 5.1% in men). In a multivariate logistic regression model, age, mental disease, pelvic organ prolapse repair, and fecal incontinence were independently associated with a greater risk of internal anal sphincter dysfunction in women and men. Conclusions: Internal anal sphincter dysfunction is a common problem for women and men. Several of the identified risk factors are preventable or modifiable, and may direct future research in fecal incontinence therapy.

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