Pathophysiology and Pharmacology of Aspirin-Induced Asthma

Szczeklik, A; Virchow, C; Schmitz-Schumann, M

doi:10.1007/978-3-642-75855-3_10

Cited by 10 publications

(1 citation statement)

References 79 publications

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“…In about I 0% of adults with asthma, but rarely in asthmatic children, aspirin and other nonsteroidal antiinflammatory drugs (NSAID) precipitate asthma attacks. This distinct clinical syndrome is called aspirininduced asthma (AlA) [1,2] . Inhibition of cyclooxygenase appears to initiate a chain of reactions, leading to asthma attacks in intolerant patients [3).…”

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confidence: 99%

Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma

Sładek¹,

Szczeklik²

1993

Eur Respir J

124

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In order to examine the hypothesis that in aspirin-induced asthma (AIA) cyclooxygenase inhibition is associated with enhanced release of leukotrienes (LTs), we measured urinary leukotriene E4 (LTE4) and 11-dehydro-thromboxane B2 (TXB2) (as a measure of cyclooxygenase production) following challenge with oral aspirin or inhaled methacholine, in 10 AIA patients. We also determined serum tryptase and eosinophilic catonic protein (ECP) levels, in order to evaluate mast cell and eosinophil activation. Urinary LTE4 excretion was increased sevenfold 4-6 h after aspirin challenge, while 11-dehydro-TXB2 decreased gradually reaching 50% baseline levels 24 h after challenge (p < 0.05). This was accompanied by a significant fall in blood eosinophil count at 6 h, and a tendency to a rise in ECP. The intensity of both LTE4 and 11-dehydro-TXB2 responses depended on the dose of aspirin used (p < 0.001, analysis of variance (ANOVA)). The accompanying maximum fall in forced expiratory volume in one second (FEV1) was not correlated with peak LTE4 levels. In contrast to aspirin, methacholine challenge producing comparable bronchial obstruction, did not alter eicosanoid excretion or serum tryptase or ECP levels. In a separate study, lysine-aspirin inhalation challenge was performed in seven AIA patients, four of whom had responded with a rise in serum tryptase to oral aspirin challenge. Challenge with inhaled aspirin led to similar bronchoconstriction as with oral challenge, but non-respiratory symptoms such as scarlet flush or rhinorrhea were absent, and serum tryptase levels remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

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confidence: 99%