Aspirin, Related Nonsteroidal Anti-Inflammatory Agents, Sulfites, and Other Food Additives as Precipitating Factors in Asthma

The Effect of Zileuton on Anosmia in Aspirin-Sensitive Asthmatics

“…It is postulated that ASA sensitivity emanates from an upregulation of the 5-lipoxygenase pathway with the resultant production of mediators such as leukotrienes. 2 Nasal obstruction and disorders of the sense of smell, common accompanying symptoms in ASA-sensitive asthmatics, are particularly difficult to control in this subgroup of patients. Although nasal challenge with histamine induces nasal pruritus, sneezing, discharge, and transient nasal blockage, H-l antihistamines alleviate all of these symptoms with the exception of nasal blockage.…”