Pathophysiology and Classification of PoTS

Lloyd, Matthew G.; Raj, Satish R.

doi:10.1007/978-3-030-54165-1_5

Cited by 1 publication

(1 citation statement)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the slopes of the regression lines were not significantly different, as well as the Y‐axis intercept, both in the supine position and at end‐tilt (Figure 2 ). POTS is a complex disease and pathophysiological mechanisms involve hypovolemia, neuropathy, and hyperadrenergic states, as well as involvement of the immune system, mast cell disorders, physical deconditioning, norepinephrine transporter deficiency, and impaired cerebral autoregulation (Lloyd & Raj, 2021 ). However, many of the mechanisms may also be involved in the ME/CFS patients with a normal HR and BP response during the tilt.…”

Section: Discussionmentioning

confidence: 99%

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

van Campen,

Rowe,

Verheugt

et al. 2023

Physiological Reports

View full text Add to dashboard Cite

Brain perfusion is sensitive to changes in CO2 levels (CO2 reactivity). Previously, we showed a pathological cerebral blood flow (CBF) reduction in the majority of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients during orthostatic stress. Limited data are available on the relation between CO2 and CBF changes in ME/CFS patients. Therefore, we studied this relation between ME/CFS patients and healthy controls (HC) during tilt testing. In this retrospective study, supine and end‐tilt CBF, as measured by extracranial Doppler flow, were compared with PETCO2 data in female patients either with a normal heart rate and blood pressure (HR/BP) response or with postural orthostatic tachycardia syndrome (POTS), and in HC. Five hundred thirty‐five female ME/CFS patients and 34 HC were included. Both in supine position and at end‐tilt, there was a significant relation between CBF and PETCO2 in patients (p < 0.0001), without differences between patients with a normal HR/BP response and with POTS. The relations between the %CBF change and the PETCO2 reduction were both significant in patients and HC (p < 0.0001 and p = 0.0012, respectively). In a multiple regression analysis, the patient/HC status and PETCO2 predicted CBF. The contribution of the PETCO2 to CBF changes was limited, with low adjusted R2 values. In female ME/CFS patients, CO2 reactivity, as measured during orthostatic stress testing, is similar to that of HC and is independent of the type of hemodynamic abnormality. However, the influence of CO2 changes on CBF changes is modest in female ME/CFS patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

van Campen,

Rowe,

Verheugt

et al. 2023

Physiological Reports

View full text Add to dashboard Cite

show abstract

Pathophysiology and Classification of PoTS

Cited by 1 publication

References 78 publications

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

Contact Info

Product

Resources

About

Pathophysiology and Classification of PoTS

Cited by 1 publication

References 78 publications

Influence of end‐tidal CO2 on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

Influence of end‐tidal CO2 on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

Contact Info

Product

Resources

About

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome

Influence of end‐tidal CO₂ on cerebral blood flow during orthostatic stress in controls and adults with myalgic encephalomyelitis/chronic fatigue syndrome