Pathophysiologie der Migräne im klinischen Kontext

Schürks, Markus; Diener, H.-C.

doi:10.1007/s00482-008-0693-1

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…One possible explanation for the association between changes in craniocervical posture in patients with migraines and TMD is the mechanism of convergence of trigeminal and cervical afferents onto the same neurons in the brainstem 14 . This convergence of afferent nerves can lead to the development of cervical pain symptoms in patients with TMD and migraines, resulting in a limited range of motion 15 and changes in head and cervical posture.…”

Section: Introductionmentioning

confidence: 99%

Body posture changes in women with migraine with or without temporomandibular disorders

Ferreira¹,

Bevilaqua-Grossi²,

Dach³

et al. 2014

Braz. J. Phys. Ther.

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BackgroundMigraine and temporomandibular disorders (TMDs) are reported to be associated. However, there are no reports on the association among migraines, TMDs and changes in body posture. ObjectivesTo assess changes in body posture in women suffering migraines with or without TMD compared with a control group. MethodSixty-six women with a mean age of 18 to 45 years participated in this study. The groups were composed of 22 volunteers with migraine and TMD (MTMD), 22 volunteers with migraines without TMD (MG) and 22 women in the control group (CG). Static posture was assessed by photogrammetry, and 19 angles were measured. ResultsPostural asymmetry was observed in the face for 4 angles measured on the frontal plane in the MG group and for 4 angles of the trunk in the MG and MTMD groups with respect to CG. However, for comparisons between MTMD and CG, clinical relevance was identified for two angles of the sagittal plane (Cervical and Lumbar Lordosis, Effect Size - ES - moderate: 0.53 and 0.60). For comparisons between the MG and CG, the clinical relevance/potential was verified for three angles with moderate ES (ES>0.42). The clinical relevance when comparing MTMD and CG was identified for four angles of facial symmetry head inclination (ES>0.54) and for two angles between MG and CG (ES>0.48). Conclusion The results demonstrated the presence of postural changes compared with a control group in women with migraines with or without TMD, and there were similar clinically relevant postural changes among the patients with migraines with and without TMD.

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Section: Introductionmentioning

confidence: 99%

Body posture changes in women with migraine with or without temporomandibular disorders

Ferreira¹,

Bevilaqua-Grossi²,

Dach³

et al. 2014

Braz. J. Phys. Ther.

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“…Although CSD occurs concurrently with the aura phase, it is thought to underlie not only the aura symptomatology but also the delayed headache phase of migraine (54). Thus, the increased trigeminal nociception caused by vasodilatation and neurogenic inflammation can be understood as a result of Cortical Spreading Depression (11,12,(46)(47)(48)(49)(51)(52)(53)(54)(55).…”

Section: Model Of the Pathophysiology Of Migrainementioning

confidence: 99%

“…Therefore, research into the pathomechanism and the effect of migraine medications plays an important role in improving future migraine therapy. Neuronal and vascular processes and the interplay between them lead to migraine (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Contingent Negative Variation and afterimage duration in migraine patients

Giesen,

Rimmele,

Jürgens

et al. 2024

Front. Neurol.

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BackgroundAbnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migraine.ObjectivesTo date, no studies have investigated both afterimage duration and CNV parameters in the same subjects. The aim of this study was to investigate the relationship between the early component of CNV (iCNV) and the duration of the afterimage in migraine patients.MethodsSixty seven migraine patients from the headache center of the University of Rostock Medical Center were examined for iCNV amplitude, iCNV habituation and afterimage duration. The subjects also completed questionnaires developed for this study and the MIDAS (Migraine Disability Assessment) questionnaire.ResultsAssociations were found between iCNV amplitude and afterimage duration and between habituation capacity and afterimage duration. A deficit in habituation capacity correlated with a significantly prolonged afterimage duration. Increased iCNV amplitude and prolonged afterimage duration were also significantly correlated.ConclusionConclusions about the pathophysiology of migraine can be drawn from the results of this study. The results support the hypothesis of cortical hyperexcitability as a consequence of a low pre-activation level, which may be a possible contributory cause of migraine. Furthermore, they allow assessment of whether the afterimage examination, which is easier and quicker to perform than the CNV examination, can be used as a diagnostic tool or as a parameter to monitor the course of therapy in people with migraine.

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Was ist Migräne?

Schürks

2009

Nervenarzt

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Migraine is a multifactorial and heterogeneous disorder. Diagnostic criteria have been established by the International Headache Society, however these are only supportive in terms of definition. The pathophysiology involves neuronal and vascular phenomena. The former is supported by the cortical spreading depression being the aura correlate and by brainstem and hypothalamic activation during the pain phase; the latter is suggested by the association between migraine and cardiovascular disease and findings of pathological vasoreactivity and endothelial dysfunction. Triptans and calcitonin gene-related peptide receptor antagonists show only a relative migraine-specific action; up to 30% of patients are nonresponders. Despite a clear genetic component, the discovery of specific genes for common forms of migraine remains elusive. Electrophysiological studies consistently indicate a characteristic "dyshabituation" concurring with clinical features of altered sensory perception. The age- and sex-specific pattern along with the effect of external factors on the course of migraine argue in favor of the involvement of epigenetic mechanisms. Knowledge about migraine is still limited, which hampers a definition.

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Pathophysiologie der Migräne im klinischen Kontext

Cited by 6 publications

References 44 publications

Body posture changes in women with migraine with or without temporomandibular disorders

Body posture changes in women with migraine with or without temporomandibular disorders

Relationship between Contingent Negative Variation and afterimage duration in migraine patients

Was ist Migräne?

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