Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis

Gebru, Yoseph Asmelash; Choi, Mi Ran; Ganesan, Raja; Gupta, Haripriya; Sharma, Satya Priya; Choi, Ye Rin; Kim, Hyeong Seop; Yoon, Sang Jun; Kim, Dong Joon; Suk, Ki Tae

doi:10.3390/microorganisms9020296

Cited by 12 publications

(9 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 67 MAIT cells detect antigens via Major histocompatibility complex class I-related gene protein (MR1), a protein predominantly expressed by B cells. 77 When MAIT cells come into contact with a variety of bacteria, they respond by detecting vitamin B2 biosynthesis pathway products via T-cell receptor (TCR) recognition. 67 …”

Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

View full text Add to dashboard Cite

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and the immune system is impaired, subsequent effects can be triggered on the skin, potentially promoting the development of skin diseases. The mechanisms through which the gut microbiome affects skin health are still unclear. Enhancing our understanding on the connection between skin and gut microbiome is needed to find novel ways to treat human skin disorders. In this review, we systematically evaluate current data regarding microbial ecology of healthy skin and gut, diet, pre- and probiotics, and antibiotics, on gut microbiome and their effects on skin health. We discuss potential mechanisms of the gut-skin axis and the link between the gut and skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. This review will increase our understanding of the impacts of gut microbiome on skin conditions to aid in finding new medications for skin-associated diseases.

show abstract

Section: Methodsmentioning

confidence: 99%

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…NKT cells and MAIT cells are the non-conventional T cells that can recognize bacterial lipid antigens presented by CD1d and metabolites produced during bacterial biosynthesis of vitamin B2 (Riboflavin) presented by MR1, respectively. The stimulation of liver tissue-resident MAIT cells is strictly correlated with the relative abundances of bacterial species capable of biosynthesizing the above metabolite ligands which are in turn dependent on the presence of functional rib genes in the species [58]. In murine models, the frequency, maturation and phenotype of NKT cells have also been confirmed to be greatly impacted by the gut microbiota [59].…”

Section: Nk Cellsmentioning

confidence: 99%

T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Gebru

Gupta

Kim

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by hepatic accumulation of excess lipids. T cells are commonly classified into various subsets based on their surface markers including T cell receptors, type of antigen presentation and pathophysiological functions. Several studies have implicated various T cell subsets and natural killer (NK) cells in the progression of NAFLD. While NK cells are mainly components of the innate hepatic immune system, the majority of T cell subsets can be part of both the adaptive and innate systems. Several studies have reported that various stages of NAFLD are accompanied by the accumulation of distinct T cell subsets and NK cells with different functions and phenotypes observed usually resulting in proinflammatory effects. More importantly, the overall stimulation of the intrahepatic T cell subsets is directly influenced by the homeostasis of the gut microbiota. Similarly, NK cells have been found to accumulate in the liver in response to pathogens and tumors. In this review, we discussed the nature and pathophysiological roles of T cell subsets including γδ T cells, NKT cells, Mucosal-associated invariant T (MAIT) cells as well as NK cells in NAFLD.

show abstract

“…The physiological process of gluconeogenesis, AMPK activity, and insulin sensitivity in the liver are significantly affected ( 52 , 55 ). Finally, SCFAs are a significant signaling metabolome and are used for communication between host tissues and microbiota through the gut-brain-liver axis ( 56 , 57 ).…”

Section: Gut Microbiota and Short Chain Fatty Acidsmentioning

confidence: 99%

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

The gut microbiome and microbial metabolomic influences on liver diseases and their diagnosis, prognosis, and treatment are still controversial. Research studies have provocatively claimed that the gut microbiome, metabolomics understanding, and microbial metabolite screening are key approaches to understanding liver cancer and liver diseases. An advance of logical innovations in metabolomics profiling, the metabolome inclusion, challenges, and the reproducibility of the investigations at every stage are devoted to this domain to link the common molecules across multiple liver diseases, such as fatty liver, hepatitis, and cirrhosis. These molecules are not immediately recognizable because of the huge underlying and synthetic variety present inside the liver cellular metabolome. This review focuses on microenvironmental metabolic stimuli in the gut-liver axis. Microbial small-molecule profiling (i.e., semiquantitative monitoring, metabolic discrimination, target profiling, and untargeted profiling) in biological fluids has been incompletely addressed. Here, we have reviewed the differential expression of the metabolome of short-chain fatty acids (SCFAs), tryptophan, one-carbon metabolism and bile acid, and the gut microbiota effects are summarized and discussed. We further present proof-of-evidence for gut microbiota-based metabolomics that manipulates the host's gut or liver microbes, mechanosensitive metabolite reactions and potential metabolic pathways. We conclude with a forward-looking perspective on future attention to the “dark matter” of the gut microbiota and microbial metabolomics.

show abstract

Pathophysiological Roles of Mucosal-Associated Invariant T Cells in the Context of Gut Microbiota-Liver Axis

Cited by 12 publications

References 89 publications

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

T Cell Subsets and Natural Killer Cells in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease

Contact Info

Product

Resources

About