Pathophysiological effects caused by the venom of the social wasp Synoeca surinama

Silva, Juliana de Castro e; Oliveira, Fagner Neves; Moreira, Karla; Mayer, Andréia Biolchi; Freire, Daniel; Cherobim, Mariana D.; Oliveira, Nelson Gomes de; Schwartz, Carlos; Schwartz, Elisabeth Ferroni; Mortari, Márcia Renata

doi:10.1016/j.toxicon.2016.02.005

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…For this study, a peptide from the mastoparan family isolated from the venom of the Synoeca surinama wasp, measuring 14 amino acid residues in length and named synoeca‐MP, was used (Silva et al, ). AMPs also presented versatile characteristics against the development of bacterial resistance, demonstrating in the literature less significant indexes when compared with the antimicrobials routinely used in a hospital environment (Bechinger & Gorr, ).…”

Section: Discussionmentioning

confidence: 99%

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Synergistic activity of chlorhexidine and synoeca‐MP peptide against Pseudomonas aeruginosa

Dantas

Lima

Cantuária

et al. 2019

Journal Cellular Physiology

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‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬This study aims to evaluate the in vitro antimicrobial and immunomodulatory activities and cytotoxicity of chlorhexidine (CHX) and synoeca‐MP peptide alone or in combination against Pseudomonas aeruginosa. The antimicrobial property was evaluated by the determination of minimal inhibitory concentration, minimum bactericidal concentration, and planktonic bacteria and biofilm inhibition. Immunomodulatory activity was determined by enzyme‐linked immunosorbent assay and nitric oxide production by the Griess reaction method. According to the results, synoeca‐MP combined with CHX demonstrated antimicrobial effectiveness compared with its isolated use, in addition to immunomodulatory activity (upregulating MPC‐1 and tumor necrosis factor‐α and downregulating nitric oxide and interleukin‐10). In this context, it is expected that the substances, together, could be capable of controlling bacterial infection and dissemination, besides potentiating macrophages’ immune response against the studied microorganism. Moreover, reducing the CHX concentration by the addition of synoeca‐MP peptide may, in a beneficial way, minimize the undesirable effects of both, CHX and synoeca‐MP in a clinical setting.

show abstract

Section: Discussionmentioning

confidence: 99%

“…For this study, a peptide from the mastoparan family isolated from the venom of the Synoeca surinama wasp, measuring 14 amino acid residues in length and named synoeca-MP, was used (Silva et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Synergistic activity of chlorhexidine and synoeca‐MP peptide against Pseudomonas aeruginosa

Dantas

Lima

Cantuária

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

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Wasp venom peptide, synoeca‐MP, from Synoeca surinama shows antimicrobial activity against human and animal pathogenic microorganisms

et al. 2019

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The rising number of multidrug-resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca-MP consists of an antimicrobial peptide (AMP) classified as a mastoparan, which was isolated from the venom of Synoeca surinama, a social wasp. Synoeca-MP presented a potent antimicrobial activity, with values of MIC 50 and MIC 90 against methicillin-resistant Staphylococcus aureus-MRSA (1.9 and 2.2 μM), Escherichia coli ESBL (2.0 and 2,1 μM), vancomycin-resistant Enterococcus faecalis (8.3 and 17.1 μM), Pseudomonas aeruginosa metallo-ß-lactamase (5.2 and 5.9 μM), and Klebsiella pneumoniae KPC (3.5 and 4.7 μM). Synoeca-MP was also tested against six Candida species, with MICs varying from 10 to 40 μM. Moreover, the structural prediction for Synoeca-MP demonstrated a cationic α-helix capable of interacting with in silico membranes and low hemolytic activity. Due to its antimicrobial activity, synoeca-MP shows potential as an adjuvant to antibiotics and antifungals commonly used in antibiotic therapies. K E Y W O R D S antimicrobial peptides, pathogenic microorganisms, Synoeca surinama

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Diversity of compounds in Vespa spp. venom and the epidemiology of its sting: a global appraisal

2020

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Pathophysiological effects caused by the venom of the social wasp Synoeca surinama

Cited by 8 publications

References 31 publications

Synergistic activity of chlorhexidine and synoeca‐MP peptide against Pseudomonas aeruginosa

Synergistic activity of chlorhexidine and synoeca‐MP peptide against Pseudomonas aeruginosa

Wasp venom peptide, synoeca‐MP, from Synoeca surinama shows antimicrobial activity against human and animal pathogenic microorganisms

Diversity of compounds in Vespa spp. venom and the epidemiology of its sting: a global appraisal

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