Pathophysiological dilemmas of lipedema

Long-term benefit of liposuction in patients with lipoedema: a follow-up study after an average of 4 and 8 years

“…Lipoedema is a disease whose pathophysiology is not understood, and for which many questions are unanswered with respect to therapeutic treatment . The improvements in mobility, cosmetic appearance and quality of life observed in this study are therefore both comprehensible and logical.…”

Altered body composition, lipedema, and decreased bone density in individuals with Williams syndrome: A preliminary report

“…Divergent prevalence estimates exist due to various factors, such as whether patients were identified in the general population or in a specialty clinic [Child and others 2010; Fife and others 2010; Forner-Cordero and others 2012]. Currently, the etiology of lipedema is unknown, but familial clustering is noted and mechanistic hypotheses include impaired estrogen signaling and microangiopathy due to endothelial barrier dysfunction [Szel and others 2014]. Several aspects of the lipedema-like phenotype seen in WS merit special mention because they are distinct from general population lipedema.…”

SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema

“…Deregulation of miR-188-5p might hence contribute to the endothelial barrier dysfunction and lymphangiopathy, which has been described in lipedema 44 . This suggests also a potential involvement of the mesenchymal stem cell populations of the SVF in the progression of lipedema, which are participating in the formation and stabilization of vessels 45 .…”