Pathophysiologic significance of “stress” or relative polycythemia in essential hypertension

Chrysant, Steven G.; Fröhlich, Edward D.; Adamopoulos, Panayotis; Stein, Paul D.; Whitcomb, Walter H.; Allen, E. W.; Neller, Gary

doi:10.1016/0002-9149(76)90426-4

Cited by 61 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study we confirm the relation between higher hematocrit and hypertension reported in other studies. 23 Our main conclusion is that hematocrit does not influence the short-term outcome of cerebral infarction cases.…”

Section: Discussionmentioning

confidence: 72%

Hematocrit and clinical outcome in acute cerebral infarction.

Ozaita

Calandre

Peinado

et al. 1987

Stroke

View full text Add to dashboard Cite

Hematocrits of 131 cerebral infarction cases were correlated with the outcome at 2 weeks. Bivariate analysis showed that cases with more intense admission deficit had lower admission hematocrit and that cases with poorer outcome had lower Day 2 and 4 hematocrits. However, multivariate analysis of several prognostic factors (including hematocrit, glycemia, blood pressure, age, and sex) showed that hematocrit was not independently related to outcome. Higher hematocrit thus is not indicative of less favorable short-term outcome.

show abstract

Section: Discussionmentioning

confidence: 72%

Hematocrit and clinical outcome in acute cerebral infarction.

Ozaita

Calandre

Peinado

et al. 1987

Stroke

View full text Add to dashboard Cite

show abstract

“…Onthe other hand, it has been reported that patients with essential hypertension have relative polycythemia (7). Hyperviscosity is improved whenhypertension is treated.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hypertension with Severe Systemic Hypertension, Raynaud's Phenomenon and Relative Polycythemia.

Murata¹,

Kuroda²,

Nakajima³

et al. 2001

Intern. Med.

View full text Add to dashboard Cite

A 32-year-old Japanese manwas hospitalized for evaluation of unconsciousness. He was diagnosed as having primary pulmonary hypertension (PPH) with severe systemic hypertension, Raynaud's phenomenon and relative polycythemia. Hemostatic studies revealed increased coagulation and decreased fibrinolysis, similar to findings of chronic disseminated intravascular coagulation (DIC). Although activation of coagulation and systemic hypertension were improved after treatment with phlebotomy and administration of nifedipine, enerapril and warfarin, pulmonary hypertension was unchanged, suggesting that irreversible change had already occurred in the pulmonary arteries. Those complications could modify the process of pulmonary hypertension by inducing a hyperviscosity state. (Internal Medicine 40: 905-910, 2001)

show abstract

“…We found that increased whole blood viscosity in unselected patients with mild essential hypertension accounted for the entire increase in peripheral resistance in them as compared with normotensive subjects drawn from the same employed population. 52 Finally, high rates of cardiovascular morbidity have been reported in patients with hyperviscosity due to hypertension 53 or so-called pseudo-polycythemia. 54 No study, however, had related blood viscosity to objective cardiac measurements in patients with hypertension.…”

Section: Blood Viscositymentioning

confidence: 99%

Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables.

Devereux¹,

Pickering²,

Alderman³

et al. 1987

Hypertension

View full text Add to dashboard Cite

SUMMARY In less than a decade since development of echocardiographic measurement of left ventricular muscle mass, studies using this technique have provided considerable information about the prevalence and pathophysiology of left ventricular hypertrophy in human hypertension. Increased left ventricular mass has been found in a significant minority of patients with systemic hypertension, with the exact prevalence dependent both on how a population is selected and on the sex, race, and possibly age composition of its members. All published studies have reported that left ventricular hypertrophy is more closely related to blood pressure recorded in the patient's natural setting during normal activity or exercise -whether measured by portable recorder or home manometer -than to blood pressure measured by the physician. In addition, studies indicate that the classic hypertensive abnormalities of concentric left ventricular hypertrophy and increased peripheral resistance are interrelated, while left ventricular hypertrophy is absent in a subgroup of patients with mild essential hypertension who exhibit high cardiac output and evidence of supernormal myocardial contractility. Conversely, the left ventricular functional response to exercise is inversely related to the degree of hypertrophy. High levels of blood viscosity, which would tend to blunt the reduction in peripheral resistance expected during sleep or exercise, have also been associated with left ventricular hypertrophy in patients with essential hypertension. Echocardiographic studies have provided evidence both for and against the hypothesis that activity of the sympathetic or reninangiotensin systems plays a direct role in causing hypertensive cardiac hypertrophy. These findings demonstrate the useful role that echocardiographic assessment of left ventricular structure and function may play in hypertension research. patients with systemic hypertension -being both a J necessary adaptation to pump a normal amount of blood against the increased pressure load and a pathologic manifestation of hypertensive cardiovascular disease. For many years, knowledge of the complex status of the heart in human hypertension advanced slowly because of the lack of suitable means of measuring cardiac anatomy and function in unselected hypertensive patients or of following their natural history. The development over the last decade of accurate echocardiographic methods for detection of LVH and characterization of ventricular contractile performance has catalyzed an explosion of information about the heart in hypertension.

show abstract

Pathophysiologic significance of “stress” or relative polycythemia in essential hypertension

Cited by 61 publications

References 22 publications

Hematocrit and clinical outcome in acute cerebral infarction.

Hematocrit and clinical outcome in acute cerebral infarction.

Primary Pulmonary Hypertension with Severe Systemic Hypertension, Raynaud's Phenomenon and Relative Polycythemia.

Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables.

Contact Info

Product

Resources

About