Pathomorphology of extraplacental membranes in their premature rupture and undifferentiated connectivetissue dysplasia in women

Saryeva, Olga P.; Peretyatko, L. P.; Vakhromeev, A. P.; Pareishvili, V. V.

doi:10.17116/patol20198104126

Cited by 2 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The unity between CT defects and the formation of uteroplacental insufficiency is also proved not only due to the defeat of connective tissue fibers of elastic or mixed type arteries, but also through the development of endothelial microvascular dysfunction [13,14], which causes a tendency to uterine bleeding (menorrhagia, pathological blood loss after childbirth and abortion), and in the perinatal aspect -an increased frequency of hemorrhages, in particular, cephalohematoma [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Correction of Cardio-hemodynamics and Endothelial Function Disorders in Pregnant Women with Connective Tissue Dysplasia

Dobrianska¹,

Heryak²,

Shve³

2022

Act Sci wom hea

View full text Add to dashboard Cite

Objectives:The negative impact of undifferentiated connective tissue dysplasia (UCTD) in myocardial contractility and endothelial microvascular dysfunction and their frequent combination with cardiac arrhythmias suggests an unfavorable course to pregnancy and childbirth due to the formation of uteroplacental dysfunction. The Aim of the Study:To reduce the incidence of obstetric complications in pregnants with UCTD by carnitine-arginine complex.Materials and Methods: There were examined 58 pregnants with UCTD, including mitral valve prolaps with and without frequent extrasystoles, and 14 pregnants of control group. Metabolic support by intravenous infusion of L-arginine and L-carnitine complex.Results: There are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction and significantly more often diagnosed with obstetrics complications in pregnant women with MVP and extrasystolic arrhythmia on the background of UCTD. There was a significant reduction of arrhythmias in patients with MVP and frequent ventricular (90.6%) or mixed extrasystoles (77.8%) under the influence of complex drug treatment with L-arginine and L-carnitine. Conclusion:There are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction, which are triggers of complicated pregnancy and childbirth in pregnant women with MVP and extrasystolic arrhythmia on the background of UCTD in the initial state. The inclusion of L-arginine and L-carnitine led to a significant improvement in the parameters of central cardiohemodynamics and restoration of endothelial function of microvessels and pregnancy complications.

show abstract

Section: Introductionmentioning

confidence: 99%

Correction of Cardio-hemodynamics and Endothelial Function Disorders in Pregnant Women with Connective Tissue Dysplasia

Dobrianska¹,

Heryak²,

Shve³

2022

Act Sci wom hea

View full text Add to dashboard Cite

show abstract

Pregnancy and delivery in women with undifferentiated connective tissue dysplasia: clinical and morphological aspects

Saryeva

Павловна²,

Vahromeev³

et al. 2021

I.P. Pavlov Russian Medical Biological Herald

View full text Add to dashboard Cite

Aim. This study aimed to identify peculiarities of the course of pregnancy, delivery, and morphology of the placenta in women with undifferentiated connective tissue dysplasia (UCTD). Materials and Methods. The main group included 60 pregnant women with UCTD, and the control group was composed of 30 somatically healthy women with physiological course of pregnancy. All patients were examined as regards the use of general clinical and laboratory methods. Moreover, 65 placentas were subjected to complex morphological examinations, including organometry, macro- and microscopic examinations, and immunohistochemistry. Results. Pregnancy and delivery in women with UCTD encounter various complications, such as threat of premature birth and miscarriage, pre-eclampsia, prenatal amenorrhea, and placental insufficiency manifested as fetal growth restriction syndrome and confirmed in the course of morphological examination. The structural basis of chronic placental insufficiency is associated various pathologies of the umbilical cord and disorders in maturation of the villous chorion with the underlying weak adaptive and compensatory processes. Connective tissue dysplasia in fetal membranes is manifested as disorders in histo- and cytoarchitectonics and in increased expression of matrix metalloproteinase-9 by amniocytes and cytotrophoblast cells. Conclusion. UCTD produces unfavorable effect on the course of pregnancy and delivery. The results of the clinical and morphological examinations demonstrate the multiorgan characteristics of injuries in the mother-placenta-fetus system, which necessitates further studies for the determination of complex prophylactic measures.

show abstract

Pathomorphology of extraplacental membranes in their premature rupture and undifferentiated connectivetissue dysplasia in women

Cited by 2 publications

References 3 publications

Correction of Cardio-hemodynamics and Endothelial Function Disorders in Pregnant Women with Connective Tissue Dysplasia

Correction of Cardio-hemodynamics and Endothelial Function Disorders in Pregnant Women with Connective Tissue Dysplasia

Pregnancy and delivery in women with undifferentiated connective tissue dysplasia: clinical and morphological aspects

Contact Info

Product

Resources

About