Correction of Cardio-hemodynamics and Endothelial Function Disorders in Pregnant Women with Connective Tissue Dysplasia

Abstract

Objectives:The negative impact of undifferentiated connective tissue dysplasia (UCTD) in myocardial contractility and endothelial microvascular dysfunction and their frequent combination with cardiac arrhythmias suggests an unfavorable course to pregnancy and childbirth due to the formation of uteroplacental dysfunction. The Aim of the Study:To reduce the incidence of obstetric complications in pregnants with UCTD by carnitine-arginine complex.Materials and Methods: There were examined 58 pregnants with UCTD, including mitral valve prolaps with and without frequent extrasystoles, and 14 pregnants of control group. Metabolic support by intravenous infusion of L-arginine and L-carnitine complex.Results: There are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction and significantly more often diagnosed with obstetrics complications in pregnant women with MVP and extrasystolic arrhythmia on the background of UCTD. There was a significant reduction of arrhythmias in patients with MVP and frequent ventricular (90.6%) or mixed extrasystoles (77.8%) under the influence of complex drug treatment with L-arginine and L-carnitine. Conclusion:There are violations of morpho-functional parameters of the heart with the development of moderate systolic-diastolic myocardial dysfunction and endothelial microvascular dysfunction, which are triggers of complicated pregnancy and childbirth in pregnant women with MVP and extrasystolic arrhythmia on the background of UCTD in the initial state. The inclusion of L-arginine and L-carnitine led to a significant improvement in the parameters of central cardiohemodynamics and restoration of endothelial function of microvessels and pregnancy complications.