Pathomorphological changes in the structure of intervertebral disc after seven and fourteen days of experimental opioid use

Abstract

We aimed to study the pathomorphological changes in the structure of intervertebral disc in the early stages of the experimental opioid use. This goal was achieved by the use of histological visualization of the intervertebral disc's structures. Histological specimens were prepared according to the typical methods using such specimens as hematoxylin, eosin, azan and due to Heidenhain method, McManus PAS-reaction and Steedman alcian blue method.