Pathology of Spontaneous and Experimental Infection of North American Wild Ruminants with<i>Mycobacterium paratuberculosis</i>

Williams, Elizabeth; Snyder, S. P.; Martin, Kathy L.

doi:10.1177/030098588302000304

Cited by 54 publications

(40 citation statements)

References 11 publications

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“…4,31 Focal necrosis and mineralization, although rare in bovines, has been frequently reported in paratuberculosis lesions in the small ruminants with or without parasitic infection. 37 The observation of caseation and Vet Pathol 43: 4,2006 necrosis in the intestine and lymph node of 1 buffalo indicated uncommonality of lesions in buffalo paratuberculosis. 31 Like Mycobacterium avium subsp.…”

Section: Discussionmentioning

confidence: 99%

“…12 Being a major domesticated ruminant in Asia, its importance with regard to control and eradication of paratuberculosis cannot be underestimated. Because buffaloes belong to a separate genus, Bubalus, the pathology of paratuberculosis infection in cattle 4,13,24,31 and other ruminants 5,10,16,25,26,28,34,37 is not likely to be similar. The objective of the present study was to describe the gross and histologic lesions of naturally occurring paratuberculosis in water buffaloes.…”

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Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

et al. 2006

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Abstract. Gross and histologic lesions of paratuberculosis were studied in water buffaloes. Small intestines and associated mesenteric lymph nodes of 405 water buffaloes were examined. Of these, 20 animals having visible changes of intestinal thickening, mucosal corrugations, and enlargement of mesenteric lymph nodes exhibited histologic alteration characteristics of mild to moderate granulomatous inflammation. The histologic lesions observed in these animals were classified into 3 grades on the basis of type of cellular infiltration, granuloma formation, and presence of acid-fast bacilli. Grade-1 lesions observed in 8 animals were marked by the presence of scattered epithelioid macrophages amid large number of lymphocytes in the intestinal villi and in the paracortical regions of the associated mesenteric lymph nodes. Another 8 animals classified under grade-2 revealed microgranulomas, infiltration with a larger number of epithelioid macrophages besides lymphocytes in the intestinal villi, and granulomas in the mesenteric lymph nodes. Grade-3 lesions observed in 4 animals were characterized by the presence of epithelioid granulomas and giant cells in the intestines and the mesenteric lymph nodes. The Ziehl-Neelsen's stained tissue sections revealed acid-fast bacilli in grade-3 and -2 animals and acid-fast granular debris in grade-1 animals. Among these 20 buffaloes, 14 (70%) were positive in the IS900 specific polymerase chain reaction and 6 (30%) were positive in the bacterial culture.

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Section: Discussionmentioning

confidence: 99%

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Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

et al. 2006

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“…Additionally, spontaneous cases of Johne's disease have been found in many species of wild animals. In North America, M. paratuberculosis has been isolated from white-tailed deer (44,261), mule deer (322,323), bighorn sheep (322,323), Rocky Mountain goats (322,323), bison (28), and elk (323). Similarly, M. paratuberculosis has been found in wild red deer from the Italian Alps (220) and wild rabbits in Scotland (6,140,141).…”

Section: Disease Control Natural Reservoirsmentioning

confidence: 99%

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

2001

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Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnostics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures

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“…Mesenteric lymph nodes are moderately large and oedematous. Focal necrosis and mineralisation of mesenteric and ileocecal lymph nodes can be present in all species with high prevalence in deer (Williams et al, 1983). The serosal lymphatic vessels of the involved jejunum and ileum are dilated and appeared beaded.…”

Section: Pathologico-anatomical Alterationsmentioning

confidence: 99%

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

Ayele¹,

Macháčková²,

Pavlík³

2001

Vet. Med. - Czech

105

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Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) infects domestic cattle, sheep, goats, deer, camelids and wild ruminants leading to chronic enteritis known as paratuberculosis (Johne’s disease). The infection is chronic, progressive and unresponsive to treatment. Most infected animals do not develop clinical disease but may excrete the bacteria. Clinically sick animals suffer emaciation and in some species diarrhoea, followed by eventual death. During the course of the disease, excretion of M. paratuberculosis in faeces and milk occurs, and the organism spreads through the blood and lymph vessels of infected animals to multiple internal organs. The infection disseminates to both the female and male reproductive organs. Though M. paratuberculosis is not classified as a human pathogen, current opinions on the possible role of this mycobacteria in public health is discussed. This article attempts to review the ways and circumstances by which M. paratuberculosis is transmitted within an animal population and the importance of the disease on animal production. Published reports concerning the transmission and epidemiology of the disease are reviewed herein, and preventive and control measures are summarised.

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Pathology of Spontaneous and Experimental Infection of North American Wild Ruminants withMycobacterium paratuberculosis

Cited by 54 publications

References 11 publications

Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

Pathology of Naturally Occurring Paratuberculosis in Water Buffaloes (Bubalus bubalis)

Mycobacterium aviumsubsp.paratuberculosisin Veterinary Medicine

The transmission and impact of paratuberculosis infection in domestic and wild ruminants

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