Pathology of Mycobacterium bovis Infection in Wild Meerkats (Suricata suricatta)

Drewe, Julian Ashley; Foote, A. K.; Sutcliffe, Robert; Pearce, G.P.

doi:10.1016/j.jcpa.2008.09.004

Cited by 39 publications

(58 citation statements)

References 26 publications

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“…Although excretion via the respiratory tract appears to occur frequently in meerkats, other routes such as suppurating skin wounds have been found to be important in some. 18 Furthermore, mycobacteria may be shed intermittently from tuberculous animals. 11,34 Other factors that may have contributed to the low tracheal wash culture sensitivity in the current study include imperfect sampling technique (tracheal washes may have sampled only airways rather than lung tissue), temperature fluctuations during storage and transport, small sample volume, and loss of viable mycobacteria during the decontamination stage.…”

Section: Discussionmentioning

confidence: 99%

“…8 Natural infection with M. bovis has been present in a study population of free-living meerkats (Suricata suricatta) in the Kalahari Desert of South Africa for several years. 18 To better understand the epidemiol-ogy of bTB in meerkats, and in particular to elucidate the role of specific social interactions in transmission of this infectious disease, accurate and simple tests to determine exposure to and shedding of M. bovis are needed.…”

Section: Introductionmentioning

confidence: 99%

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Accuracy of Three Diagnostic Tests for Determining Mycobacterium Bovis Infection Status in Live-Sampled Wild Meerkats (Suricata Suricatta)

Drewe¹,

Dean

Michel

et al. 2009

J VET Diagn Invest

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Abstract. Accurate diagnosis of Mycobacterium bovis infection (bovine tuberculosis [bTB]) in live animals is notoriously problematic. The aim of the present study was to evaluate the diagnostic potential of 2 new serologic tests (multiantigen print immunoassay [MAPIA] and lateral flow immunoassay rapid test [RT]) in comparison with mycobacterial culture of tracheal washes for determining M. bovis infection status in a freeranging population of wild meerkats (Suricata suricatta). During a longitudinal study lasting 2.5 years, 240 individually identifiable meerkats were each sampled up to 8 times under anesthesia every 3 months. Diagnostic accuracy was determined through Bayesian and maximum likelihood estimations of sensitivity, specificity, and likelihood ratios for each diagnostic test when used independently and in parallel to classify the disease status of individual meerkats in the absence of a gold standard. Culture of tracheal washes was highly specific (0.99; 95% confidence interval [CI] 5 0.77, 1.00) but of low sensitivity (0.36; 95% CI 5 0.24, 0.50) for diagnosing M. bovis-infected individuals. The longitudinal nature of the study with repeated sampling of the same individual animals served simultaneously to improve chances of detecting infection and increase confidence in a negative result in individual animals repeatedly testing negative. Although MAPIA and RT were individually of limited diagnostic use, interpreting the results of these 2 tests in parallel produced estimates of sensitivity (0.83; 95% CI 5 0.67, 0.93) and specificity (0.73; 95% CI 5 0.62, 0.82) high enough to usefully inform decision making when determining exposure to bTB in wild meerkats and potentially other species in which bTB poses a diagnostic challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accuracy of Three Diagnostic Tests for Determining Mycobacterium Bovis Infection Status in Live-Sampled Wild Meerkats (Suricata Suricatta)

Drewe¹,

Dean

Michel

et al. 2009

J VET Diagn Invest

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“…Despite significant variations in size, appearance and distribution of the tuberculous lesions in different species, in the majority of affected wildlife species lesions closely resemble those in cattle (Zanella et al, 2008;Drewe et al, 2009). A consistently different pattern of pathological changes has, however, been described in lions where no histological evidence of necrosis was found (Keet et al, 1996).…”

Section: Disease In Wildlifementioning

confidence: 99%

Mycobacterium bovis at the animal–human interface: A problem, or not?

Michel

Müller

Helden

2010

Veterinary Microbiology

273

234

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“…7,15 Mycobacteriosis, another important zoonotic disease, was recently reported in freeranging and zoo meerkats. 5,16 From public health and treatment perspectives, it is important to differentiate Yersinia spp. from other organisms using immunohistochemistry and bacterial identification.…”

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confidence: 99%

Yersiniosis due to infection by Yersinia pseudotuberculosis 4b in captive meerkats (Suricata suricatta) in Japan

et al. 2015

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Two meerkats (Suricata suricatta) housed in the same zoological garden in Japan died due to Yersinia pseudotuberculosis serotype 4b infection. Gross and microscopic lesions included necrotizing enteritis and enlargement of the spleen and liver with multifocal necrosis. Inflammatory cells, primarily neutrophils, and nuclear debris were associated with clusters of Gram-negative bacilli. Additionally, there were aberrant organism forms that were larger than bacilli and appeared as basophilic globular bodies. Immunohistochemical examination showed that the bacilli and globular bodies were strongly positive for Y. pseudotuberculosis O4 antigen. The globular bodies were considered a shape-changed form of Y. pseudotuberculosis, and these morphologically abnormal bacteria could present a diagnostic challenge.

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Pathology of Mycobacterium bovis Infection in Wild Meerkats (Suricata suricatta)

Cited by 39 publications

References 26 publications

Accuracy of Three Diagnostic Tests for Determining Mycobacterium Bovis Infection Status in Live-Sampled Wild Meerkats (Suricata Suricatta)

Accuracy of Three Diagnostic Tests for Determining Mycobacterium Bovis Infection Status in Live-Sampled Wild Meerkats (Suricata Suricatta)

Mycobacterium bovis at the animal–human interface: A problem, or not?

Yersiniosis due to infection by Yersinia pseudotuberculosis 4b in captive meerkats (Suricata suricatta) in Japan

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