Pathology of Fibrocystic Diseases of the Liver

Caroli syndrome in a dog

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Hepatocytes and bile ducts have the same hepatoblast precursors. The differentiation between these two liver components is orchestrated by regulatory factors and genes responsible for the formation of the ductal plate (ARNON et al, 2010;NGUYEN TRUONG & YEH, 2010). Caroli disease is the direct result of the failure of involution of ductal plates, which leads to the formation of large intrahepatic ducts.

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“…Caroli disease is the direct result of the failure of involution of ductal plates, which leads to the formation of large intrahepatic ducts. The condition is characterized by multiple large intrahepatic cysts that are contiguous with the biliary tree (NGUYEN TRUONG & YEH, 2010). Caroli syndrome is characterized by a combination of intrahepatic biliary ductal ectasia and congenital ductal fibrosis (GÖRLINGER et al, 2003;NGUYEN TRUONG & YEH, 2010;PILLAI et al, 2016).…”

“…The condition is characterized by multiple large intrahepatic cysts that are contiguous with the biliary tree (NGUYEN TRUONG & YEH, 2010). Caroli syndrome is characterized by a combination of intrahepatic biliary ductal ectasia and congenital ductal fibrosis (GÖRLINGER et al, 2003;NGUYEN TRUONG & YEH, 2010;PILLAI et al, 2016). In dogs, several cases of Caroli's disease and syndrome have been associated with significant renal cyst formation (GÖRLINGER et al, 2003;HELGERT…”