Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique

Roggli, Victor L.; Gibbs, A R; Attanoos, Richard; Churg, Andrew; Popper, Helmut; Corrin, B.; Franks, Teri J.; Galateau-Salle, Françoise; Galvin, J R; Hasleton, Philip; Honma, Koichi

doi:10.5858/arpa.2015-0503-sa

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…Asbestos-induced model of lung fibrosis is clearly distinguished from IPF by several histologic findings including asbestos bodies embedded within the fibrous tissue, fewer myofibroblasts foci and bronchial wall fibrosis. In some cases, the pattern of UIP can be also present ( 55 , 56 ). Some of these features are recapitulated in inhalation models in animals and have helped us understand the pathogenesis of both asbestosis and IPF ( 57 – 61 ).…”

Section: Murine Modelsmentioning

confidence: 99%

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis

Tashiro¹,

Rubio²,

Limper³

et al. 2017

Front. Med.

228

223

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Large multicenter clinical trials have led to two recently approved drugs for patients with idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease progression and do not provide a definitive cure. Traditionally, preclinical trials have utilized mouse models of bleomycin (BLM)-induced pulmonary fibrosis—though several limitations prevent direct translation to human IPF. Spontaneous pulmonary fibrosis occurs in other animal species, including dogs, horses, donkeys, and cats. While the fibrotic lungs of these animals share many characteristics with lungs of patients with IPF, current veterinary classifications of fibrotic lung disease are not entirely equivalent. Additional studies that profile these examples of spontaneous fibroses in animals for similarities to human IPF should prove useful for both human and animal investigators. In the meantime, studies of BLM-induced fibrosis in aged male mice remain the most clinically relevant model for preclinical study for human IPF. Addressing issues such as time course of treatment, animal size and characteristics, clinically irrelevant treatment endpoints, and reproducibility of therapeutic outcomes will improve the current status of preclinical studies. Elucidating the mechanisms responsible for the development of fibrosis and disrepair associated with aging through a collaborative approach between researchers will promote the development of models that more accurately represent the realm of interstitial lung diseases in humans.

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Section: Murine Modelsmentioning

confidence: 99%

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis

Tashiro¹,

Rubio²,

Limper³

et al. 2017

Front. Med.

228

223

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“…Concerning the inflammatory markers, no difference was noticed between the NLR and ESR values in the 2 groups (p =0.734 and p=0.958, respectively), when recorded at baseline (in 2014) (fig 1). We interpret this in the context of the low level of inflammation and the slow progression that are the main distinctive histological features of this particular lung fibrosis [13]. There is evidence that asbestos has a direct mechanical injury, generates reactive oxigen species on its surface, alters the cellular signal transduction pathways and silences the Table 1 MAIN CHARACTERISTICS OF THE STUDY GROUPS tumours supressor genes, while activating the prooncogens.…”

Section: Resultsmentioning

confidence: 80%

“…Fibroblast foci are rare, but at least mild fibrosis of the visceral pleura is present. [13] The smoking induced fibrosis has also a centriacinar development, but lacks the honeycomb aspect, the pleural involvement and the fibroblastic foci; in contrast, it associates the other pathological consequences of smoking exposure: bronchiolitis and emphysema. [14] In our study, we could not attribute progression to differences in smoking habits, as the distribution between eversmokers (current and past) and non smokers was not statistically significant (χ 2 = 0.810, p=0.368).…”

Section: Resultsmentioning

confidence: 99%

Inflammation Markers in the Evolution of Asbestosis

Oțelea¹,

Andrei²,

Dinu³

et al. 2019

Rev. Chim.

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Asbestos structure and composition contribute to the lung injury and to the inflammation induced by this natural fiber. The result of this study is that neutrophile to lymphocyte ratio correlates significantly to timing of progress of the radiological lesions in the evolution of patients with asbestosis, followed for 5 years. If confirmed in larger studies, this could become a cost-effective biomarker for the asbestosis evolution.

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“…Current guidelines make recommendations for the diagnosis of asbestosis based on surgical biopsy sample sizes . However, these do not reflect the increasingly available and potentially safer method of transbronchial cryobiopsy, which, as our case has demonstrated, can also provide large‐enough lung samples to demonstrate asbestos bodies in sufficient numbers to be helpful in attributing the cause of pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 83%

Transbronchial lung cryobiopsy: a novel confirmatory tool to diagnose asbestos‐related pulmonary fibrosis

Zajaczkowska

Gallur

et al. 2018

Respirology Case Reports

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Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. A 73 year old man presented with dyspnoea on a background of rheumatoid arthritis, previous methotrexate use and asbestos exposure. Examination revealed fine crackles in the mid and lower zones bilaterally without signs of pulmonary hypertension. The presence of pleural plaques and basal interstitial reticulation on HRCT was suggestive of asbestosis but histology was required to differentiate this from rheumatoid or methotrexate associated ILD. Samples of lung tissue were obtained via transbronchial cryobiopsy, demonstrating fibrosis and asbestos fibres consistent with asbestosis. Transbronchial cryobiopsy appears effective in obtaining sufficient parenchymal lung samples to diagnose asbestosis when clinical uncertainty exists.

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Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique

Cited by 14 publications

References 15 publications

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis

Inflammation Markers in the Evolution of Asbestosis

Transbronchial lung cryobiopsy: a novel confirmatory tool to diagnose asbestos‐related pulmonary fibrosis

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