Inflammation Markers in the Evolution of Asbestosis

Oțelea, Marina Ruxandra; Andrei, Nicoleta; Dinu, E; Stefanescu, Cristian Dragos; Hainăroşie, Răzvan; Handra, Claudia Mariana

doi:10.37358/rc.19.6.7295

Cited by 1 publication

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References 15 publications

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“…However, there are still countries, such as Russia, Kazakhstan, China, Brazil, and Zimbabwe that continue to produce and export asbestos [ 6 , 7 ]. All types of asbestos are currently considered fibrogenic and carcinogenic [ 5 ], and there is no safe limit for asbestos exposure [ 8 ]. Human mesothelial cells are very sensitive to the deleterious effects of asbestos which induce the production of reactive oxygen and nitrogen species, the release of TNF-α, growth factors, and other cytokines, and DNA damage [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Near Missed Case of Occupational Pleural Malignant Mesothelioma, a Case Report and Latest Therapeutic Options

Handra

Chirila

Smărăndescu

et al. 2022

IJERPH

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Asbestos use started to be gradually banned in Europe from 1991 onwards, and there are currently strict occupational exposure limits for asbestos. However, malignant mesothelioma has a long latency time (in some cases up to 50–60 years), so the risks related to asbestos exposure should not be forgotten. Considering the increased risk of lung cancer following the inhalation of asbestos fibers, lifetime health monitoring should be considered in people occupationally exposed to asbestos, with an emphasis on the respiratory system. An assessment of their occupational history should be performed rigorously, especially in the areas with a history of asbestos production/use, as this is a key element for an early diagnosis and appropriate treatment. This case report presents a near-missed case of occupational pleural malignant mesothelioma. The latency time between the first asbestos exposure and the diagnosis of occupational pleural malignant mesothelioma was 49 years. The accurate diagnosis was made two years after the first symptoms appeared.

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