Pathology of 157 human cadaver eyes with round-edged or modern square-edged silicone intraocular lenses: Analyses of capsule bag opacification

Maddula, Surekha; Werner, Liliana; Ness, Peter J.; Davis, Don; Zaugg, Brian; Stringham, Jack; Burrow, Michael; Yeh, Oliver

doi:10.1016/j.jcrs.2010.10.058

Cited by 18 publications

(13 citation statements)

References 27 publications

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“…1 In a subset of our series of pseudophakic cadaver eyes, eyes with 3-piece square-edged silicone IOLs, which are relatively new in the market, had significantly better PCO prevention results than eyes with 3-piece roundedged silicone IOLs. 20 After the introduction of 1-piece square-edged hydrophobic acrylic IOLs, studies comparing the PCO prevention of these IOLs with that of their 3-piece counterparts became available. 3,10-17 In a study by Sacu et al, 10 although eyes with 1-piece IOLs had slightly more PCO than eyes with 3-piece IOLs 1 year after implantation (PZ.002), the difference was no longer present after 2 years (PZ.3).…”

Section: Discussionmentioning

confidence: 99%

Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Ness¹,

Werner²,

Maddula³

et al. 2011

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Ness¹,

Werner²,

Maddula³

et al. 2011

Journal of Cataract and Refractive Surgery

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“…Following technological advances, IOL design has been modified from round-edged to square-edged, and this has resulted in a reduction in the incidence of PCO (24) . However, studies suggest that square-edged IOLs should completely encompass the 360 degrees around the IOL optic in order to provide an effective barrier (25) .…”

Section: Discussionmentioning

confidence: 99%

Incidence of posterior capsule opacification following the implantation of a foldable hydrophilic acrylic intraocular lens: a 4 year follow-up study

Jorge

Jorge²,

Ventura

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate the incidence of posterior capsule opacification (PCO) four years after the implantation of a hydrophilic acrylic intraocular lens (IOL). Methods: Fifty-eight randomly selected eyes from 58 patients were analyzed four years after phacoemulsification and Ioflex IOL implantation. The patients underwent an ophthalmic examination to detect PCO and a detailed medical history was obtained. The patients' charts were reviewed for their corrected distance visual acuity prior to the IOL implantation, as well as for one month postoperatively. The Student's t-test was used for statistical analysis. Results: The mean age of patients without PCO was 74.6 ± 9.5 years, compared to 70.3 ± 15 years in patients with PCO. Four years after surgery, 39 of the 58 eyes (67%) had detectable PCO and 24 eyes (41.3%) had decreased visual acuity (VA) due to PCO. These patients were referred for Nd:YAG laser capsulotomy. Three patients (5.1%) had decreased VA due to glaucoma, IOL opacification, or age-related macular degeneration. Twelve eyes (20.7%) presented mild PCO with unchanged VA. Systemic arterial hypertension was reported by 45% of the patients, and in 3.5% of these cases this was associated with diabetes mellitus. Conclusion: This study found the incidence of PCO to be 67% four years after phacoemulsification and Ioflex IOL implantation.

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“…This ultrasound provided imaging of the entire anterior segment of the eye via a noncontact, immersion technique. 19,20 …”

Section: Methodsmentioning

confidence: 99%

Pathologic Comparison of Asymmetric or Sulcus Fixation of 3-Piece Intraocular Lenses with Square Versus Round Anterior Optic Edges

et al. 2013

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Objective To evaluate pathologic findings of 3-piece intraocular lenses (IOLs) with asymmetric or sulcus fixation in pseudophakic cadaver eyes, comparing IOLs with square or round edges on the anterior optic surface. Design Comparative case series with pathology. Participants 661 pseudophakic cadaver eyes obtained from eye banks within the United States, implanted with different IOLs Methods Anterior segment scanning of whole eyes with a high-frequency ultrasound system, or with a high-resolution anterior segment magnetic resonance imaging, followed by gross examination. Selected eyes were processed for complete histopathologic analysis. Main Outcome Measures Findings from imaging, gross, and histopathologic evaluation that could be related to out-of-the-bag fixation of the lenses. Results Out of 661 pseudophakic cadaver eyes obtained, 13 had 3-piece hydrophobic acrylic IOLs with anterior and posterior square optic edges, and 14 had 3-piece lenses with anterior round edges (13 silicone lenses, and 1 hydrophobic acrylic lens) without symmetric in-the-bag fixation. These 27 selected eyes were processed for complete histopathologic analysis. Gross findings in both groups were composed of IOL decentration and tilt, pigmentary dispersion within the anterior segment and on the IOL surface, and iris transillumination defects. Histopathology of the 14 eyes with 3-piece IOLs with round anterior optic edges showed mild focal disruption of the iris pigmented layer, and loop protrusion/erosion in the ciliary sulcus. Additional changes observed in the 13 eyes with square anterior optic edge IOLs included iris changes such as vacuolization, disruption and loss of the pigmented epithelial layers, iris thinning and atrophy, synechiae, and pigmentary dispersion within the trabecular meshwork. One eye also exhibited initial signs of optic nerve disc cupping. Conclusion In this series, pathologic findings were more severe in eyes implanted with 3-piece IOLs with square anterior optic edges, suggesting that IOLs with round anterior edges are more suitable for sulcus fixation.

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Pathology of 157 human cadaver eyes with round-edged or modern square-edged silicone intraocular lenses: Analyses of capsule bag opacification

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 18 publications

References 27 publications

Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: Capsular bag opacification and sites of square-edged barrier breach

Incidence of posterior capsule opacification following the implantation of a foldable hydrophilic acrylic intraocular lens: a 4 year follow-up study

Pathologic Comparison of Asymmetric or Sulcus Fixation of 3-Piece Intraocular Lenses with Square Versus Round Anterior Optic Edges

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