Pathology: Diseases of Bone

Lymph node involvement by Langerhans cell histiocytosis: a clinicopathologic and immunohistochemical study of 20 cases

“…LCH can involve many different anatomical sites including bone [1][2][3], skin, neurohypophysis, oral cavity, anogenital region, lungs, liver, spleen, kidney, and lymph nodes [4][5][6][7][8]. The occurrence of LCH in lymph nodes, either as a primary isolated manifestation of the disease or as a part of systemic disease, has been previously described in the literature [9][10][11][12].…”

“…Langerhans cell histiocytosis (LCH) is a pathologic process that occurs most commonly in bones [1][2][3]. However, LCH has also been described in a number of other anatomical locations including skin, neurohypophysis, oral cavity, anogenital region, lungs, liver, spleen, and kidney [4][5][6][7][8].…”

Histiocytosis X (Granulomatous Reticuloendotheliosis)

“…The term is brief and inclusive and obviates the need for cumbersome terminology. The contributions to the histogenesis of histiocytosis X (under its various other names) by Färber,11 Green,14 Jaffe and Lichtenstein,18'22' 23 Mallory,24 and Engelbreth-Holm 10 have been most important in elucidating the common denominator of this basic reticuloendothelial reaction. Special¬ ized case reports, too numerous to detail, and clinical reviews have delineated the variability of form which this tissue re¬ sponse can produce.…”

ACUTE RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE)<subtitle>Report of a Case in Which Several Unusual Features Are Combined</subtitle>

“…13 Otitis media, cholesterolemia, thrombopenia, monocytosis, soft mottling in lung fields on roentgenograms, and early cirrhotic changes in liver have all been men¬ tioned by other authors. 13 Otitis media, cholesterolemia, thrombopenia, monocytosis, soft mottling in lung fields on roentgenograms, and early cirrhotic changes in liver have all been men¬ tioned by other authors.…”