Histiocytosis X (Granulomatous Reticuloendotheliosis)

Langerhans cell histiocytosis with prominent nail involvement

“…To our knowledge, 21 previous cases of LCH with nail changes have been reported in the literature (Table 1). [4][5][6][9][10][11][12][13][14][15][16][17][18][19][20] As in other studies, 4,14,16,18,19 histopathologic differences between skin and nail lesions of LCH were not observed in our patient, but secondary change of acute inflammatory crusting was seen in the nail specimen.…”

“…Among the largest pediatric series, including 32 patients in the United States and 124 patients in Mexico, no cases of patients with LCH and nail involvement were identified. To our knowledge, 21 previous cases of LCH with nail changes have been reported in the literature (Table ) . As in other studies, histopathologic differences between skin and nail lesions of LCH were not observed in our patient, but secondary change of acute inflammatory crusting was seen in the nail specimen.…”

“…Nail involvement in LCH is thought to be rare and was first reported by Bender and Holtzman in 1958, followed by Kahn in 1969 . Among the largest pediatric series, including 32 patients in the United States and 124 patients in Mexico, no cases of patients with LCH and nail involvement were identified.…”

Histiocytosis X in an Adult with Skin and Uncommon Central Nervous System Involvement

“…These three terms are used to point out the differences, which may occur in the clinical picture, in the activity and also the prognosis of this disease. They may best be regarded as being, respectively, the acute disseminated, the chronic progressive, and the benign localized form of histiocytosis X [2,12]. On the other hand, the nosologic entity of these three syndromes is stressed by the fact that different types of transitional forms between Abt-Letterer-Siwe disease, Hand-Schiiller-Christian disease and eosinophilic granuloma of the bone are not uncommon [3,4,12].…”