Pathology and Pathogenesis of Ovine Pulmonary Adenocarcinoma

Griffiths, David J.; Martineau, Henny; Cousens, Chris

doi:10.1016/j.jcpa.2009.12.013

Cited by 95 publications

(142 citation statements)

References 146 publications

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“…In addition, the results of this study showed that the rate of viral infection detected by real-time PCR is much higher compared to histopathological examination. This is in agreement with previous reports demonstrating that the number of JSRV infected animals is much higher than the number that will ever develop the disease (3,10,26). In addition, histopathological lesions were found in 11 out of 15 PCR positive samples, indicating higher sensitivity of real-time PCR.…”

Section: Discussionsupporting

confidence: 92%

The Soaking Resistance of Electronic Storage Media

Iraci

2017

Restaurator. International Journal for the Preservation of Library and Archival Material

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Introduction: The aim of this study was to use TaqMan real-time PCR technique to investigate Jaagsiekte sheep retrovirus (JSRV) proviral DNA in whole blood samples of sheep, and compare the results to those of histopathological examinations. Material and Methods: Eighty blood samples from clinically healthy sheep were randomly collected before the animals were slaughtered. Ten tissue samples from each lung and associated caudal mediastinal lymph node were taken. Results: Fifteen (18.75%) blood samples were found to contain proviral DNA, and 11 (13.75%) corresponding lung samples showed microscopic changes consistent with ovine pulmonary adenocarcinoma. None of the samples displayed metastases to the caudal mediastinal lymph nodes. The prominent pattern of neoplastic nodules consisted of acinar (alveolar) form. Conclusion: The results indicated the higher sensitivity of real-time PCR compared to histopathological examinations in detection of ovine pulmonary adenocarcinoma.

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Section: Discussionsupporting

confidence: 92%

The Soaking Resistance of Electronic Storage Media

Iraci

2017

Restaurator. International Journal for the Preservation of Library and Archival Material

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“…The tumors can fill a large portion of the nasal cavity before clinical signs develop, which includes abundant seromucinous nasal discharge [2,3]. Clinical signs are usually slowly progressive, with additional clinical signs being dyspnea, facial deformities, exophthalmia, and weight loss [4]. These neoplasms are typically invasive, predominantly low grade and rarely metastasize [3,5].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…JSRV induces neoplastic transformation of alveolar and bronchial secretory epithelial cells which results in pulmonary tumors [4]. The main clinical sign is difficulty in breathing which is due to pulmonary edema that may drain from the nostrils [4]. Similar to ENA, a definitive diagnosis of OPA requires further diagnostic testing: gross and histologic evaluation, immunohistochemistry using antibodies against JSRV proteins, PCR with JSRV specific primers, and/or TEM.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to ENA, OPA is a contagious disease that is spread through contact of nasal drainage. It can infect sheep of any age, but is usually diagnosed in sheep between 2 and 4 years of age [4]. This disease has been reported in many sheep-rearing regions around the world including the United States.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Case of Enzootic Nasal Adenocarcinoma in a Ewe

Stowe

Anderson

Guy

et al. 2012

Case Reports in Veterinary Medicine

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An approximately 2-year-old open Suffolk ewe presented to the North Carolina State University College of Veterinary Medicine Veterinary Health Complex for evaluation of a left nasal mass. An ultrasound-guided aspirate and core biopsies were performed. An epithelial neoplasia with mild mixed inflammation (neutrophils and plasma cells) was diagnosed on cytology and confirmed on histopathology. Immunohistochemistry (IHC), reverse transcriptase polymerase chain reaction (RT-PCR), and transmission electron microscopy were also performed. IHC and RT-PCR identified the presence of enzootic nasal tumor virus and confirmed the final diagnosis of enzootic nasal adenocarcinoma.

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Tumors of the Respiratory Tract

Wilson

2016

Tumors in Domestic Animals

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Pathology and Pathogenesis of Ovine Pulmonary Adenocarcinoma

Cited by 95 publications

References 146 publications

The Soaking Resistance of Electronic Storage Media

The Soaking Resistance of Electronic Storage Media

A Case of Enzootic Nasal Adenocarcinoma in a Ewe

Tumors of the Respiratory Tract

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