Pathological findings in the human auditory system following long-standing gentamicin ototoxicity

Backus, R. M.; Groot, J. C. M. J. De; Tange, R. A.; Huizing, Egbert H.

doi:10.1007/bf00458549

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Several views of this relationship can be suggested: (1) that an IHC can release signals that affect the survival of nearby neurons which it does not contact; (2) that, after IHC loss, axons stripped of synaptic contact sprout to connect to surviving IHCs; or (3) that there are signaling interactions among IHCs and supporting cells such that surviving IHCs induce increased synthesis/release of trophic factors (e.g., neurotrophins) from surrounding supporting cells. It is not clear whether any, or all, of these occur; however, there are reports that peripheral axons resprout after hair cell loss from either acoustic overexposure (Strominger et al 1995) or aminoglycoside-induced hair cell death (Backus et al 1987;Tange and Huizing 1980).…”

Section: Primary Vs Secondary Degenerationmentioning

confidence: 96%

Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss

Sugawara

Corfas

Liberman

2005

JARO

110

113

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In sensorineural hearing loss, hair cell loss is often followed by loss of cochlear nerve fibers, which can continue for years after the insult. The degree and time course of neuronal loss varies, but the reasons for this variation are unclear. The present study addresses this issue with a quantitative analysis of hair cell, supporting cell, and neuronal survival in animals with long-term survival of up to 5.5 years from two types of drug-induced hair cell loss: aminoglycoside antibiotics and platinum-containing chemotherapeutics. To complement the analysis of the effects of organ of Corti damage on neuronal survival, cases of primary neuronal degeneration, via auditory nerve section, are also assessed. Analysis shows that (1) long-term neuronal survival is enhanced when supporting cells in the inner hair cell (IHC) area remain intact; (2) after hair cell loss, the time course of neuronal loss is slower in the apex than in the base; (3) primary loss of cochlear nerve fibers does not lead to secondary degeneration of sensory cells or supporting cells in the organ of Corti; and (4) after auditory nerve section, there can be a massive reinnervation of the IHC region, especially in the apex. Results are consistent with the idea that supporting cells participate in the regulation of neuronal survival and neuronal sprouting in the organ of Corti.

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Section: Primary Vs Secondary Degenerationmentioning

confidence: 96%

Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss

Sugawara

Corfas

Liberman

2005

JARO

110

113

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“… 17–31 However, aminoglycoside ototoxicity provides the majority of examples of human temporal bone, including patients treated with streptomycin, 15,17–20 neomycin, 10,15,18,21,22 kanamycin, 18,20,23–28 amikacin, 9,10 and gentamicin. 9,10,12,15,29–32 In addition, there are many other descriptions of patients who were given combinations of ototoxic medications, and descriptions of tobramycin effects are among these. 9,10,12 …”

Section: Introductionmentioning

confidence: 99%

Aminoglycoside Ototoxicity: A Human Temporal Bone Study

et al. 2001

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“…Hearing damage associated with aminoglycoside use can include permanent hearing loss and tinnitus secondary to the degradation of sensorineural hair cells of the cochlea and/ or vestibule. Damage to cochlear hair cells is thought to be mediated by oxidative stress, starting at the base where highfrequency sounds are decoded and advancing to the apex 6,8,13,14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…These agents are cost-effective and widely used in lowand middle-income countries 2,3 . Yet, aminoglycoside use for the treatment of MDR-TB is associated with ototoxicity in 5-64% in cases [3][4][5][6][7][8][9][10][11] . Ototoxicity can produce hearing loss and associated psychosocial changes that negatively affect quality of life 12 .…”

Section: Introductionmentioning

confidence: 99%

The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis

Vasconcelos

Frota

Ruffino-Netto

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used. Methods: We performed a retrospective review of 599 medical records from patients with MDR-TB who were treated at the Hélio Fraga/Fiocruz Reference Center between 2006 and 2010. Cases without auditory or vestibular complaints and patients who were not treated with aminoglycoside drugs were excluded from the study. Results: Of 164 eligible cases, 55 (33.5%) reported an auditory or vestibular complaint and medication was subsequently suspended, although hearing damage was not confirmed in all cases. Audiometric testing confirmed hearing loss in 11 (21.7%) of 12 cases submitted for evaluation. Hearing loss related to ototoxicity was confirmed in 15 (62.5%) cases. Tinnitus was significantly associated with the use of amikacin and streptomycin. Conclusions: Evaluations of ototoxicity symptoms were not usually reported in the routine care of patients with MDR-TB. Complaints of tinnitus were associated with amikacin and streptomycin use. These results require confirmation in future studies.

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Pathological findings in the human auditory system following long-standing gentamicin ototoxicity

Cited by 8 publications

References 9 publications

Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss

Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss

Aminoglycoside Ototoxicity: A Human Temporal Bone Study

The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis

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