Pathological Characterization of Lymphoma with Pulmonary Involvement in Cats

Leite-Filho, Ronaldo Viana; Panziera, Welden; Bandinelli, Marcele Bettim; Pavarini, Saulo P.

doi:10.1016/j.jcpa.2018.09.007

Cited by 4 publications

(7 citation statements)

References 21 publications

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“…These three receptors were all present in the cluster C receptors (pan-expression cluster). Infection of FeLV in the myocardium, thymus, mesentery, liver, kidney, and lung has been reported in cats 47 , 48 , consistent with our observation that Flvcr1 , Slc20a1 , and Slc20a2 were highly expressed in stromal cells and distal convoluted tubule cells of the kidney, epicardial cells of the heart, and ciliated cells of the lung. Notably, the expression proportions of Slc20a1 and Slc20a2 in corresponding cell types were much higher than that of Flvcr1 .…”

Section: Resultssupporting

confidence: 92%

Single cell atlas for 11 non-model mammals, reptiles and birds

et al. 2021

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The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs.

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Section: Resultssupporting

confidence: 92%

Single cell atlas for 11 non-model mammals, reptiles and birds

et al. 2021

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“…8 Lymphomas occurring in the lungs are classified into primary neoplasms, and secondary involvement of those arising from the other thoracic organs (such as the thymus, mediastinal, sternal or tracheobronchial lymph nodes) or from extrathoracic organs (such as the liver, kidneys and spleen). 9 , 10 However, to our knowledge, pulmonary involvement of feline lymphoma has not previously been reported in cats. Based on the histological appearance, the most distinct lung neoplasm is Langerhans cell histiocytosis.…”

Section: Discussionmentioning

confidence: 88%

“…It forms macroscopic masses and nodules, and shows histologically predominant peribronchial invasion, followed by pleural, interstitial, nodular and alveolar patterns. 10 Although no clinical signs were noted for almost 7 months after surgery and chemotherapy based on the CHOP protocol, abdominal ultrasonography and FNA examination detected high-grade lymphoma in the jejunum. No gastrointestinal signs or abnormal findings in the gastrointestinal tract, including the jejunum, were detected on abdominal ultrasonography after lobectomy.…”

Section: Discussionmentioning

confidence: 95%

“… 12 , 13 In cats, primary pulmonary lymphoma has not yet been reported, although secondary involvement of lymphoma in the lung has been reported. 9 , 10 , 14 Pulmonary involvement of lymphoma is observed in 12% of the cases (16/125 on necropsy). It forms macroscopic masses and nodules, and shows histologically predominant peribronchial invasion, followed by pleural, interstitial, nodular and alveolar patterns.…”

Section: Discussionmentioning

confidence: 99%

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Primary pulmonary diffuse large B-cell lymphoma associated with feline leukaemia virus infection in a young cat

Ishikawa

Nagashima

Machida

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 4-year-old castrated male domestic shorthair cat with a continuous cough was brought to a private veterinary clinic for detailed examination. Radiography of the thoracic cavity revealed a severe radiopaque region in the caudal lobe of the right lung. At 108 days after the initial visit, CT showed a mass of 27 × 23 × 18 mm in the caudal lobe of the right lung. At that time, no abnormalities in other organs except for the lung were detected on CT and peripheral blood and blood biochemistry tests. The mass in the caudal lobe of the right lung was resected by lobectomy; it had a white surface and was firm. Histopathologically, the mass was non-encapsulated, showing an unclear boundary with surrounding tissues. The mass comprised large, round or polygonal neoplastic cells arranged in a diffuse pattern. Immunohistochemically, neoplastic cells were diffusely positive for CD20, feline leukaemia virus (FeLV) p27 and FeLV glycoprotein 70 but negative for CD3, CD204 and E-cadherin. Based on these findings, diffuse large B-cell lymphoma associated with FeLV infection was diagnosed. Although the cat showed no clinical signs of gastrointestinal or respiratory injury, a routine ultrasonography revealed thickening in the jejunum wall 196 days after lobectomy, and subsequent fine-needle aspiration examination confirmed high-grade lymphoma. Relevance and novel information This is the first report of primary pulmonary diffuse large B-cell lymphoma associated with FeLV infection in a young cat.

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“…Radiographic presentation is highly variable (Geyer and others 2010) and can be interstitial, nodular or bronchial in pattern. A recent review summarises the histological presentation of feline pulmonary lymphoma (Leite‐Filho and others 2018).…”

Section: Anatomical Presentationsmentioning

confidence: 99%

Feline lymphoma: diagnosis, staging and clinical presentations

Mason¹,

Pittaway²

2022

In Practice

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Background: Lymphoma is a neoplasm of the lymphoid tissue, which may present with localised or systemic clinical signs. Unlike dogs that commonly present with multicentric disease, mostly involving the lymphoid organs (eg, lymph nodes), feline lymphoma can present as visceral (eg, spleen/liver/ gut), extranodal (eg, CNS/skin) or nodal in origin, with clinical presentation dependant on the affected organ. This variation in clinical presentation is further complicated by further indolent forms of lymphoma that have been reported; a cat can either present as clinically unwell with intrathoracic or intra-abdominal forms, or it can present with some subcutaneous or multicentric forms, which may be systemically asymptomatic.

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Pathological Characterization of Lymphoma with Pulmonary Involvement in Cats

Cited by 4 publications

References 21 publications

Single cell atlas for 11 non-model mammals, reptiles and birds

Single cell atlas for 11 non-model mammals, reptiles and birds

Primary pulmonary diffuse large B-cell lymphoma associated with feline leukaemia virus infection in a young cat

Feline lymphoma: diagnosis, staging and clinical presentations

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