Pathological characteristics of oral lymphomas

Hashimoto, Nozomi; Kurihara, Kenji

doi:10.1111/j.1600-0714.1982.tb00159.x

Cited by 45 publications

(12 citation statements)

References 29 publications

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“…[6] Vander Waal et al .,[1] published largest number (40) of primary extranodal NHL of the oral cavity and according to his study mean age was 59 years (3–88 years) and male gender was commonly involved. He and Hashimoto,[17] (9 cases) in their study of oral lymphoma reported oral lymphoma in a 3-year-old child. In our study average age was 42.6 years and male gender was commonly affected.…”

Section: Discussionmentioning

confidence: 99%

“…While according to Teruya-Feldstein et al .,[30] the most common histotype seen in immunocompromised individuals is plasmablastic variety. Hashimoto, 1982[17] reviewed pathological characteristics of oral NHL and according to his 9 cases and review of literature he concluded that B-cell lymphoma is the most common histotype in oral NHL. However, Alexander et al ,[20] reported diffuse histiocytic lymphoma (old term for DLBL) as the most common histotype in jaw bones.…”

Section: Discussionmentioning

confidence: 99%

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Isolated primary extranodal lymphoma of the oral cavity: A series of 15 cases and review of literature from a tertiary care cancer centre in India

Shah

Panwar

Chaturvedi

et al. 2011

Indian Journal of Medical and Paediatric Oncology

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Background:Non-Hodgkin's lymphomas (NHL) have a great tendency to affect organs and tissues that do not ordinarily contain lymphoid cells. Involvement of the oral cavity by NHL is very rare.Materials and Methods:Retrospective analysis was carried out by chart review of patients who presented to our hospital between 1990 and 2008. All those patients whose histopathology at our hospital was confirmed as lymphoma were included.Results:Although we register nearly 2000 new oral cancers every year, most of which are squamous cell cancers, we could trace only 15 cases of oral lymphoma in the last 18 years. Of these, hard palate and alveolus were most common sites (5 each). The median age at presentation was 42.6 years. A vast majority (12/15) were NHL. Most patients (70%) reported with painless progressive swelling without systemic signs, such as fever, weight loss, and so on. Only 2 patients were HIV positive. Nearly two thirds received combinations of CT and RT. Cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine), prednisolone regime was the most common regime offered (12/15). Most of them (67%) had good response to 6 cycles of CT that was followed by RT. 10/15 patients completed treatment. Follow-up data of more than 2 years of follow-up was present in 11/15 patients. With median follow-up of 27 months, 5 were disease free, 5 died, and 1 controlled following 2nd line of CT, 2 were lost to follow-up and 2 were alive with disease.Discussion:Head and neck lymphoma is the second most common region for extranodal lymphoma. The nasopharynx, tonsils, and base tongue are most often involved. Unlike the western world, oral cavity involvement is extremely rare. Interestingly, only 2 patients tested positive for HIV and most were young patients. Oral lymphoma may mimic benign oral conditions that often lead to misdiagnosis.Conclusion:Although oral cavity may be the preferred site of NHL in immunocompromised patients it does occur in immunocompetent patients as well. Isolated oral lymphoma is extremely rare and from our data we can say that oral NHL in Indian sub population is more aggressive compared with western literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolated primary extranodal lymphoma of the oral cavity: A series of 15 cases and review of literature from a tertiary care cancer centre in India

Shah

Panwar

Chaturvedi

et al. 2011

Indian Journal of Medical and Paediatric Oncology

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“…Hashimoto and Kurihara (1982) and the largest case series of extranodal NHL of oral cavity (71 cases) was by Solomides et al (2002) (Table 3). In this study 42 cases of extranodal NHL of oral cavity is reported.…”

Section: Discussionmentioning

confidence: 99%

Oral Extranodal Non Hodgkin's Lymphoma: Series of Forty Two Cases in Malaysia

Ramanathan¹,

Mahmoud²,

Hui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Lymphoma is a malignant neoplasm of lymphoid tissue classified into Hodgkin's and nonHodgkin's types. It mostly affects lymph nodes although a considerable proportion of Non-Hodgkin's cases occur in extranodal sites. Materials and Methods: Selected cases diagnosed as non-Hodgkin's lymphoma (NHL) during the period of 1980 to 2012 were retrieved from the archives of the Oral Pathology Diagnostic Laboratory, Faculty of Dentistry, University of Malaya. The sections from the formalin-fixed paraffin embedded tissue blocks were stained with H&E as well as with LCA, CD20, and CD3. Results: The mean age was 41.6 years with a male: female ratio of 1.3:1. Out of the forty two cases, nineteen were Malays, eighteen were Chinese, followed by Indians (3) and Indonesians (2). The most common site of involvement was the mandible (22.2%), followed by the maxilla and palate (19.4% each). Most of the lesions presented as a painless progressive swelling. Only thirty six cases were further subdivided into B or T cell types. The majority were B-cell type (26 cases), of these 6 cases were Burkitt's lymphomas. Only ten cases were T-cell lymphoma, with three cases of NK/T-cell lymphoma. Conclusions: In this series of 42 patients diagnosed as extranodal non-Hodgkin's lymphoma, the lesions appeared as painless swellings, mostly in men with the mandible as the most frequent site of involvement. Majority were B-cell lymphomas with Malays and Chinese being equally affected whereas lymphomas were rare in the Indian ethnicity. T-cell lymphomas were found to be common in the Chinese ethnic group.

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“…[10] Hashimoto et al reviewed pathological characteristics of oral NHL and according to his nine cases and review of literature he concluded that B-cell lymphoma is the most common histological subtype in oral NHL. [11] In present study, two out of the five immunocompetent patients had DLBCL. According to Teruya-Feldstein et al, the most common histological subtype seen in immunocompromised individuals is plasmablastic variety.…”

Section: Discussionmentioning

confidence: 95%

Primary extranodal non-Hodgkin′s lymphoma of oral cavity - A single centre retrospective study

et al. 2014

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Involvement of oral cavity by lymphoma is rare. Plasmablastic lymphoma was the most common oral cavity NHL in our patients. Although number of cases in present study was less, our data suggests that oral NHL has aggressive course with less favorable outcome. Further large sample studies incorporating rituximab-based chemotherapy and more aggressive chemotherapy for plasmablastic lymphoma will be helpful for better understanding of treatment outcome.

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Pathological characteristics of oral lymphomas

Cited by 45 publications

References 29 publications

Isolated primary extranodal lymphoma of the oral cavity: A series of 15 cases and review of literature from a tertiary care cancer centre in India

Isolated primary extranodal lymphoma of the oral cavity: A series of 15 cases and review of literature from a tertiary care cancer centre in India

Oral Extranodal Non Hodgkin's Lymphoma: Series of Forty Two Cases in Malaysia

Primary extranodal non-Hodgkin′s lymphoma of oral cavity - A single centre retrospective study

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