Pathological changes observed in the finger biopsy of patients with vibration-induced white finger.

Takeuchi, Tadao; Futatsuka, Makoto; Imanishi, Hiroyasu; Yamada, Shingo

doi:10.5271/sjweh.2140

Cited by 213 publications

(135 citation statements)

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“…Experimentally, however, Karpova (7) recognized Wallerian degeneration in the peripheral nerves of rabbits. In their pathological examination of skin specimens from 30 patients with VWF, Takeuchi et al (11) found a clear increase in the thickness of the perineurium caused by connective tissue and marked perineurial fibrosis and muscular hypertrophy of the arterial walls, the last finding having also been described earlier by Ashe et al (1).…”

supporting

confidence: 58%

Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon.

Takeuchi¹,

Takeya²,

Imanishi³

1988

Scand J Work Environ Health

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TAKEUCHI T, TAKEYA M, IMANISHI H. Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon. Scand J Work Environ Health 14 (1988) 31-35. A finger biopsy was performed on three patients with vibration-induced white finger (VWF), and the specimens were examined by electron microscopy for peripheral nerve changes. A characteristic neuropathy with perineurial fibrosis was revealed which was often accompanied by a thickened perineurium with a lamellar structure resembling onion skin. This peculiar fibrosis consisted of elongated cytoplasmic projections of perineurial cells or fibroblasts and a greatly increased amount of collagen which occasionally contained fibrous long-spacing collagen. In the endoneurium, a decrease in the number of nerve fibers and a marked increase in collagen with fibroblasts were noted. Myelinated axons became smaller, and this occurrence suggested incomplete regeneration. The pathological changes were presumably the result of the long-term clinical course of VWF.

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supporting

confidence: 58%

Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon.

Takeuchi¹,

Takeya²,

Imanishi³

1988

Scand J Work Environ Health

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“…The condition may be visible during attacks of finger blanching provoked by cold, and diagnosed by excessive cold-induced reductions in finger blood flow or finger systolic blood pressure (Griffin and Bovenzi, 2002). Vibration-induced white finger affects the control of peripheral circulation in the fingers (Olsen et al, 1987), although other changes are also reported in severe cases (e.g., Takeuchi et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Relation between vibrotactile perception thresholds and reductions in finger blood flow induced by vibration of the hand at frequencies in the range 8–250 Hz

Yao

Griffin

2014

Eur J Appl Physiol

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“…Many reviews implicate activation of the somatosympathetic pathway by the pacinian vibroreceptors as the reflex mechanism producing neural activation of vasoconstriction (Sakakibara and Yamada, 1995;Stoyneva et al, 2003). Finger skin biopsies from patients with HAVS reveal vascular smooth muscle cell (SMC) hypertrophy and periarterial fibrosis (Takeuchi et al, 1986).…”

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confidence: 99%

Vibration Causes Acute Vascular Injury in a Two‐Step Process: Vasoconstriction and Vacuole Disruption

Govindaraju

Bain

Eddinger

et al. 2008

The Anatomical Record

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Hand-arm vibration syndrome is a vasospastic and neurodegenerative occupational disease. In the current study, the mechanism of vibration-induced vascular smooth muscle cell (SMC) injury was examined in a rat-tail vibration model. Tails of male Sprague Dawley rats were vibrated continuously for 4 hr at 60 Hz, 49 m/s 2 with or without general anesthesia. Ventral tail arteries were aldehyde fixed and embedded in epoxy resin to enable morphological analysis. Vibration without anesthesia caused vasoconstriction and vacuoles in the SMC. Anesthetizing rats during vibration prevented vasoconstriction and vacuole formation. Exposing tail arteries in situ to 1 mM norepinephrine (NE) for 15 min induced the greatest vasoconstriction and vacuolation. NE induced vacuoles were twice as large as those formed during vibration. When vibrated 4 hr under anesthesia after pretreatment with NE for 15 min, the SMC lacked vacuoles and exhibited a longitudinal banding pattern of dark and light staining. The extracellular matrix was filled with particulates, which were confirmed by electron microscopy to be cellular debris. The present findings demonstrate that vibration-induced vasoconstriction (SMC contraction) requires functioning central nervous system reflexes, and the physical stress of vibration damages the contracted SMC by dislodging and fragmenting SMC vacuoles. Anat Rec, 291:999

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Pathological changes observed in the finger biopsy of patients with vibration-induced white finger.

Cited by 213 publications

References 1 publication

Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon.

Ultrastructural changes in peripheral nerves of the fingers of three vibration-exposed persons with Raynaud's phenomenon.

Relation between vibrotactile perception thresholds and reductions in finger blood flow induced by vibration of the hand at frequencies in the range 8–250 Hz

Vibration Causes Acute Vascular Injury in a Two‐Step Process: Vasoconstriction and Vacuole Disruption

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