Pathological Changes and Immunoexpression of p63 Gene in Dental Follicles of Asymptomatic Impacted Lower Third Molars

Abstract

Stronger p63 gene immunoexpression in the group with completely impacted teeth might be a consequence of bigger number of stem cells than it is in the case of the group with partially impacted teeth. This study also supports prophylactic removal of impacted teeth because of the development of pathologies associated with them.

Immunohistochemical Analysis of P63 Expression in Odontogenic Lesions

“…Upregulation of P63 has been also demonstrated in some malignancies [3]. In addition, P63 gene expression has been detected in the majority of tooth germ cells and dental epithelium throughout the bud and cap stages [1]. Investigators suggest that P63 is involved in epithelial differentiation during tooth development.…”

“…P63 is a member of P53 gene family, which has a role in epithelial development, stem cell biology, and carcinogenesis [1]. P63 is also expressed in odontogenic epithelium [2, 3].…”

Ki-67 expression in pericoronal tissues of impacted mandibular third molars

“…Leitner et al, (2007) reported a patient who was diagnosed with a lowgrade malignant fibrosarcoma of the dental follicle of an impacted third molar without clinical evidence of any follicular lesion. Prophylactic removal of impacted teeth was suggested even in cases which clinically and radiographically showed normal tissues (Brkic et al, 2010). The studies examined the cystic changes of radiographically normal follicles (Glosser and Campbell, 1999;Adelsperger et al, 2000;Rakprasitkul, 2001;Baykul et al, 2005) have reported higher incidence of cysts than expected.…”

Comparison of Proliferative Activity of Epithelial Cells between the Follicles of Impacted Teeth

“…Some researches suggested that all impacted teeth should be removed to eliminate the chance of any pathology development (Rakprasitkul, 2001;Saravana & Subhashraj, 2008;Brkic et al, 2010), others claimed that prophylactic removal is unnecessary as the potential of any pathology development is very slim (Saraçoglu et al;Stephens et al, 1999;Stathopoulos et al, 2011). Despite this disagreement, only a few studies investigated cellular activity of the dental follicles of asymptomatic impacted third molars in comparison with that of odontogenic pathologies (Saraçoglu et al; Edamatsu et al; Cabbar et al; Güler et al).…”