Pathological analysis of intracranial space-occupying lesions in 1000 cases including children

Dastur, Darab K.; Lalitha, V.

doi:10.1016/0022-510x(69)90047-1

Cited by 30 publications

(13 citation statements)

References 23 publications

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“…The circumscribed and cystic lesions in this location are easily resectable, but the diffuse infiltrating lesions are managed by decompression and radiotherapy. [518]…”

Section: Discussionmentioning

confidence: 99%

“…A transient exacerbation of the clinical symptoms and the difficulty in interpreting the sample obtained are additional potential complications. [56]…”

Section: Discussionmentioning

confidence: 99%

“…[568] In four of our patients, however, who had a very small posterior third ventricular lesion and were symptomatic due to hydrocephalus consequent to aqueductal stenosis, only a CSF diversion was performed. These patients have been placed on a regular follow-up rather than subjecting them to the risk of an invasive procedure to obtain a histopathologic specimen.…”

Section: Discussionmentioning

confidence: 99%

“…For NGGCT, this modality, therefore, has an undefined role that is perhaps determined by the degree of benign tissue within the lesion. [564647]…”

Section: Discussionmentioning

confidence: 99%

“…In malignant tumors, the evidence suggests that greater resection improves response to adjuvant therapy as well as prognosis. [56]…”

Section: Discussionmentioning

confidence: 99%

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Tumors of the posterior third ventricular region in pediatric patients: The Indian perspective and a review of literature

et al. 2011

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Background:Diverse tumors in the posterior third ventricular region (TPTVR) frequently occur in children. A decade's experience with pediatric TPTVR is presented, focusing on the Indian perspective.Materials and Methods:25 children (age range: 3-18 years; mean age: 13.32 years; presentation range: 7 days-2.5 years) had clinico-radiological assessment with contrast computed tomography (CT) and magnetic resonance imaging (MRI). The ventricular/lumbar cerebrospinal fluid (CSF) alpha feto protein (AFP)/beta human chorionic gonadotrophin (HCG) estimation was done when radiological suspicion of a germ cell tumor was present. Extent of resection was deemed partial when some tumor mass remained at the end of surgery, near total when <10% was retained over vital neurovascular structures, and total when complete resection was attained.Results:Operations included infratentorial supracerebellar approach (n = 12), occipito-transtentorial approach (n = 2), endoscopic biopsy and third ventriculostomy (n = 1), frontal parasagittal craniotomy, interhemispheric transcallosal subchoroidal approach (n = 2), middle temporal gyrus transcortical transventricular approach (n = 1), fronto-temporo-zygomatic combined transylvian and subtemporal approach (n = 1) and right ventriculoperitoneal shunt and stereotactic biopsy (n = 1). Only CSF diversion was performed for five patients with a small TPTVR. CSF diversion was required in 12 (48%) patients. Tumor pathology included pinealoblastoma (n = 4; one with pineocytic differentiation), nongerminomatous germ cell tumor (NGGCT; n = 3), germinoma (n = 3), pilocytic astrocytoma (n = 2), epidermoid (n = 3) and primitive neuroectodermal tumor (PNET), fibrillary astrocytoma, glioblastoma, teratoma, and meningioma (n = 1, respectively). A patient with neurocysticercosis was diagnosed solely on MRI (four did not undergo biopsy). Fractionated radiotherapy was administered in 13 patients with primary pineal tumors, PNET, NGGCT, fibrillary astrocytoma and glioblastoma. Extent of excision was total in 10 (40%), near total in 5 (20%), partial in 3 (12%) and a biopsy in 2 (8%) patients.Conclusions:Histopathologic characterization of TPTVR is essential prior to their further management. Benign lesions often have a good prognosis following gross total surgical resection. Pure germinomas are highly susceptible to radiotherapy. NGGCTs often have malignant components that require adjuvant therapy following surgery. The advancements in microsurgical techniques have led to gratifying perioperative results in these deep-seated lesions.

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“…The circumscribed and cystic lesions in this location are easily resectable, but the diffuse infiltrating lesions are managed by decompression and radiotherapy. [518]…”

Section: Discussionmentioning

confidence: 99%

“…A transient exacerbation of the clinical symptoms and the difficulty in interpreting the sample obtained are additional potential complications. [56]…”

Section: Discussionmentioning

confidence: 99%