Pathologic Studies Following Magnetic Control of Metallic Iron Particles in the Lymphatic and Vascular System of Dogs as a Contrast and Isotopic Agent

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

“…One of these new tools is magnetic nanoparticles (MNP). 1,2 Because of their ultrafine size, biocompatibility, and superparamagnetic properties, iron oxide nanoparticles are already approved for various biomedical applications such as enhanced resolution magnetic resonance imaging 3 and cellular labeling/ cell separation [4][5][6][7] or undergoing preclinical and clinical evaluation for applications such as drug delivery, [8][9][10][11][12][13][14] tissue repair, 15 cell and tissue targeting, 16 and transfection. 17,18 Superparamagnetic iron oxide nanoparticles (SPIONs) with a mean particle diameter of about 10 nm suspended in appropriate carrier liquids are commonly called ferrofluids and have outstanding properties.…”

Technology Insight: magnetic navigation in coronary interventions

“…After these initial investigations, small external permanent magnets were used to stereotactically direct iron particles for thrombosis of intracranial aneurysms, [10][11][12] later, rotating electromagnets were used, enabling better control. 13 In 1991, Ram and Meyer performed the first magnetically guided angiography in a human.…”

Nucleic Acid Delivery and Localizing Delivery with Magnetic Nanoparticles

“…Drugs are associated with magnetically responsive materials in the nanoto micrometer-size range and in that manner can be "navigated" by magnetic force. By the mid-1960s, researchers had already attempted the first steps to produce magnetically localized thrombi in intracranial aneurisms in both animals and humans [170][171][172][173] using carbonyl iron. Pioneering work by Widder et al [174] has inspired research into magnetically accumulating drugs mostly in tumors upon administration into the circulation.…”