Pathologic Classification of Diabetic Nephropathy

Tervaert, Thijs W. Cohen; Mooyaart, Antien L.; Amann, Kerstin; Cohen, Arthur H.; Cook, H. Terence; Drachenberg, Cinthia B.; Ferrario, Franco; Fogo, Agnes B.; Haas, Mark; Heer, Emile de; Joh, Kensuke; Noël, Laure Hélène; Radhakrishnan, Jai; Seshan, Surya V.; Bajema, Ingeborg M.; Bruijn, Jan A.

doi:10.1681/asn.2010010010

Cited by 1,309 publications

(1,162 citation statements)

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“…Histopathopathological examination for kidneys obtained from diabetic rats revealed significant increase in glomerular damage (segmental glomerular sclerosis and the formation of synechiae with parietal epithelial cells with periglomerular sclerosis), loss of tubular epithelial cell brush border and arterial injury in the form of medial or intimal hyperplasia with luminal narrowing. In agreement with these findings Khanra et al [26] demonstrated thickening of glomerular and tubular basement membrane of kidneys in type 2 diabetic rats and Tervaert et al [37] demonstrated mesangial expansion in type 2 diabetic rat's kidney which might influence membrane permeability.…”

Section: Nc Group (N=10) Dm Group (N=4) Dm+afe Group (N=8) Dm+mfe Grosupporting

confidence: 61%

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Mousalamy¹,

Al-Shatri²

2016

Biochemistry & Physiology: Open Access

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Objective: The present study examined the effects of aqueous and methanolic extracts of palm dates (fruits and seeds) on diabetic nephropathy in a rat model of type 2 DM.Methods: Sixty male albino rats subdivided into a) normal control (NC) group, b) diabetic control (DM) group, c) aqueous fruit extract (AFE) group, d) methanolic fruit extract (MFE) group, e) aqueous seed extract (ASE) group and f) methanolic seed extract (ASE) group. Treatment with both extracts done for 15 weeks after induction of type 2 DM. by the end of experiment fasting blood glucose, serum lipid profile, creatinine, urea, uric acid, urinary albumin excretion, kidney tissue MDA, catalase, SOD, GSH were measured and kidney histopathological examination was done.Results: Diabetic untreated rats showed significant hyperglycemia and hyperlipidemia and deterioration in kidney functions and morphology with enhanced oxidative stress in kidney tissues. On other hand, rats treated with either aqueous or methanolic fruit or seed extracts showed significant improvement in all studied parameters compared to DM group (p<0.05). However, the effects of fruit extracts especially aqueous extract were more powerful than seed extracts. Conclusion:Aqueous and methanolic fruit and seed extracts of palm date protect kidneys from diabetic nephropathy in rats which might be due to their antioxidant properties.Citation: El-Mousalamy AMD, Hussein AAM, Mahmoud SA, Abdelaziz A, Shaker G (2016) Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats. Biochem Physiol 5: 205.

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Section: Nc Group (N=10) Dm Group (N=4) Dm+afe Group (N=8) Dm+mfe Grosupporting

confidence: 61%

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Mousalamy¹,

Al-Shatri²

2016

Biochemistry & Physiology: Open Access

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“…A score of 0 was assigned when the biopsy specimen showed no interstitial fibrosis and tubular atrophy; a score of 1 was assigned when less than 25% was affected by interstitial fibrosis and tubular atrophy; a score of 2 was assigned when at least 25% but less than 50% of the biopsy specimen had interstitial fibrosis and tubular atrophy; and finally, a score of 3 was assigned when at least 50% of the biopsy specimens was affected by interstitial fibrosis and tubular atrophy was present. 12) Immunohistochemistry was also used to examine aquaporin-2 expression in the epithelial cells of the collecting ducts relating to the mechanism of tolvaptan action and its relationship to the efficacy of tolvaptan.…”

Section: Methodsmentioning

confidence: 99%

Effect of Tolvaptan in Patients With Chronic Kidney Disease Due to Diabetic Nephropathy With Heart Failure

et al. 2014

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SummaryThe efficacy of tolvaptan for treating heart failure has already been shown. Adequate data relating to the effect of tolvaptan on the correlation of water balance in renal disease are not available. A retrospective study was conducted on the efficacy and adverse reactions of tolvaptan for treating nephrotic syndrome.The subjects were 26 patients with chronic kidney failure due to diabetic nephropathy with heart failure who were administered tolvaptan and seen between December 2011 and October 2013. The endpoints were urinary output, physical findings, and blood analyses. The expression of aquaporin-2 in the collecting duct, which is related to the action of tolvaptan, was investigated by immunohistochemistry using the kidney tissue obtained for the diagnosis.Responses were seen in 19 of the patients. In the histopathological investigation there was severe glomerulosclerosis in patients with diabetic nephropathy, but the responders were noticeable in that they only had mild tubulointerstitial damage. Non-responders exhibited profound tubulointerstitial damage. The expression of aquaporin-2 was determined in 8 patients, of which 7 were responders who tested positive for aquaporin-2. The remaining case was a non-responder who showed no expression of aquaporin-2.Tolvaptan is considered effective for some cases of nephrotic syndrome. There are no clear parameters for predicting an effect, but the present study showed that aquaporin-2 was expressed in the epithelial cells of the collecting ducts of tolvaptan responders. (Int Heart J 2014; 55: 533-538)

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“…Severe mesangial expansion occupies an area greater than the area of the capillary lumen (33). GBM, glomerular basement membrane.…”

Section: Pathophysiology Of Dkdmentioning

confidence: 99%

Diabetic Kidney Disease

Alicic

Rooney

Tuttle

2017

CJASN

1,845

786

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Pathologic Classification of Diabetic Nephropathy

Cited by 1,309 publications

References 50 publications

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

Effect of Tolvaptan in Patients With Chronic Kidney Disease Due to Diabetic Nephropathy With Heart Failure

Diabetic Kidney Disease

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