Pathogens Responsible for Early-Onset Sepsis in Suzhou, China

Lu, Lianghua; Li, Pei; Pan, Tao; Feng, Xing

doi:10.7883/yoken.jjid.2019.243

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…This distribution of pathogens would depend on the geographic area in which the study was carried out. A recent study carried out in China on the pathogens responsible for EOS found in premature babies weighing more than 800 g Group B Streptococcus (18.3%), E. coli (18.1%) followed by Listeria monocytogen (12.1%) and Klebsiella pneumoniae [18].…”

Section: Discussionmentioning

confidence: 99%

Predictors of early-onset neonatal sepsis in premature newborns: Case–control study

Takassi

Atakouma

Desfrère

2022

Archives de Pédiatrie

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Background: Early-onset neonatal sepsis (EOS) is difficult to diagnose clinically because the semiology of premature newborns is poor during the first days of life. This study aimed to identify predictive factors of EOS in neonates less than 37 weeks gestational age in neonatal care at Louis Mourier Hospital.Method: This was a case-control study of all newborns <37 weeks of gestational age diagnosed and managed for EOS from January 1 to December 31, 2019. The main parameters studied were demographic characteristics, risk factors, biological and bacteriological characteristics. At the benchmarking level, the statistical tests used were the Mac Nemar test for qualitative variables and the paired Student's test for quantitative variables.Results: A total of 50 mother-child pairs were included in this study (25 cases and 25 matched controls). The results showed a statistically significant relationship between the birth of a child suffering from an EOS and between a premature rupture of membranes (PRM)> 18 h (68% of cases versus 36% of controls ( p: 0.042)); a positive culture of the placenta (p: 0.0002); a CRP> 6 mg / l (88% of cases against 20% of controls (p: 0.001)); a PCT> 0.6 ng / ml (72% of cases vs. 16% of controls (p: 0.001)). Grams negative including E. coli (44.5%) and Haemophilus Influenzae (14.8%) were the most common bacteria found. Conclusion:The search for risk factors must be systematic. The dosage of PCT must be coupled with that of CRP and the clinic must remain at the center of the diagnostic process.

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Section: Discussionmentioning

confidence: 99%

Predictors of early-onset neonatal sepsis in premature newborns: Case–control study

Takassi

Atakouma

Desfrère

2022

Archives de Pédiatrie

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“…Unsurprisingly, MDR bacteria represent a key public health concern worldwide. With UPEC responsible for 80–95% community acquired UTI cases and 27% sepsis cases, multi-drug resistance in UPEC remains a great concern [ 1 , 2 , 3 , 4 , 5 ]. Though some forms of multi-drug resistance in UPEC may be treatable, the appearance of carbapenem resistant, extended spectrum β-lactamase producing E. coli is a great concern.…”

Section: Discussionmentioning

confidence: 99%

“…Uropathogenic Escherichia coli (UPEC) is responsible for a number of diseases in humans including urinary tract infections (UTI), and urosepsis. Together, UPEC infections place an astounding burden on healthcare worldwide, causing 80–95% of community acquired UTI cases, and 27% of sepsis cases [ 1 , 2 , 3 , 4 , 5 ]. Antibiotics have been the mainstay of treatment in bacterial infections since their introduction in the early 20th century.…”

Section: Introductionmentioning

confidence: 99%

Current and Emerging Treatment Options for Multidrug Resistant Escherichia coli Urosepsis: A Review

Walker

Roberts²,

Rogers³

et al. 2022

Antibiotics

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Escherichia coli is a versatile commensal and pathogenic member of the human microflora. As the primary causative pathogen in urosepsis, E. coli places an immense burden on healthcare systems worldwide. To further exacerbate the issue, multi drug resistance (MDR) has spread rapidly through E. coli populations, making infections more troublesome and costlier to treat. This paper aimed to review the literature concerning the development of MDR in uropathogenic E. coli (UPEC) and explore the existing evidence of current and emerging treatment strategies. While some MDR strains maybe treated with β-lactam-β-lactamase inhibitor combinations as well as cephalosporins, cephamycin, temocillin and fosfomycin, current treatment strategies for many MDR UPEC strains are reliant on carbapenems. Carbapenem overreliance may contribute to the alarming dissemination of carbapenem-resistance amongst some UPEC communities, which has ushered in a new age of difficult to treat infections. Alternative treatment options for carbapenem resistant UPEC may include novel β-lactam-β-lactamase or carbapenemase inhibitor combinations, cefiderocol, polymyxins, tigecycline, aminoglycosides or fosfomycin. For metallo-β-lactamase producing strains (e.g., NDM, IMP-4), combinations of cefazidime-avibacam with aztreonam have been used. Additionally, the emergence of new antimicrobials brings new hope to the treatment of such infections. However, continued research is required to successfully bring these into the clinic for the treatment of MDR E. coli urosepsis.

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“…Pathogens causing EOS are usually colonized in maternal genitourinary tract and with the amniotic membrane rupture are transmitted to the fetus or during the labor to neonate [20]. Most frequent EOS's pathogens are the Gram (+) group B Streptococcus (GBS) followed by the Gram (−) E. Coli bacteria [21]. Pathogens causing LOS can be transmitted during labor or from the environment.…”

Section: Introductionmentioning

confidence: 99%

Untargeted 1H-NMR Urine Metabolomic Analysis of Preterm Infants with Neonatal Sepsis

et al. 2022

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One of the most critical medical conditions occurring after preterm birth is neonatal sepsis, a systemic infection with high rates of morbidity and mortality, chiefly amongst neonates hospitalized in Neonatal Intensive Care Units (NICU). Neonatal sepsis is categorized as early-onset sepsis (EOS) and late-onset sepsis (LOS) regarding the time of the disease onset. The accurate early diagnosis or prognosis have hurdles to overcome, since there are not specific clinical signs or laboratory tests. Herein, a need for biomarkers presents, with the goals of aiding accurate medical treatment, reducing the clinical severity of symptoms and the hospitalization time. Through nuclear magnetic resonance (NMR) based metabolomics, we aim to investigate the urine metabolomic profile of septic neonates and reveal those metabolites which could be indicative for an initial discrimination between the diseased and the healthy ones. Multivariate and univariate statistical analysis between NMR spectroscopic data of urine samples from neonates that developed EOS, LOS, and a healthy control group revealed a discriminate metabolic profile of septic newborns. Gluconate, myo-inositol, betaine, taurine, lactose, glucose, creatinine and hippurate were the metabolites highlighted as significant in most comparisons.

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Pathogens Responsible for Early-Onset Sepsis in Suzhou, China

Cited by 7 publications

References 17 publications

Predictors of early-onset neonatal sepsis in premature newborns: Case–control study

Predictors of early-onset neonatal sepsis in premature newborns: Case–control study

Current and Emerging Treatment Options for Multidrug Resistant Escherichia coli Urosepsis: A Review

Untargeted 1H-NMR Urine Metabolomic Analysis of Preterm Infants with Neonatal Sepsis

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