Pathogenicity of Talfan and Konratice strains of Teschen virus in gnotobiotic pigs

Edington, N.; Christofinis, G. J.; Betts, A. O.

doi:10.1016/0021-9975(72)90038-2

Cited by 23 publications

(22 citation statements)

References 5 publications

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“…However, the resulting histological lesions were much milder than those in pigs infected naturally. Conversely, a hysterectomy study has shown that CNS disorders can indeed be induced via intranasal or oral inoculation, provided the inoculum comprises the Talfan or Konratice strains of the Teschen virus in gnotobiotic pigs (Edington et al, 1972). The aim of the present study was to clarify how PTV infection leads to lesions in pigs.…”

Section: Introductionmentioning

confidence: 99%

Experimental Teschovirus Encephalomyelitis in Gnotobiotic Pigs

Yamada

Miyazaki

Yamamoto

et al. 2014

Journal of Comparative Pathology

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A central nervous system (CNS) disorder characterized by non-suppurative encephalomyelitis with neurological signs was induced experimentally in gnotobiotic pigs by intravenous and oral or intranasal inoculation of the porcine teschovirus (PTV) Toyama 2002 strain isolated from breeding pigs in Japan. Lesions consisting of perivascular cuffing of mononuclear cells, focal gliosis, neuronal necrosis and neuronophagia were observed in the brainstem, cerebellum and spinal cord. Non-suppurative ganglionitis in the spinal ganglion and neuritis in the spinal root were also observed. Regardless of the route of inoculation, all pigs infected experimentally with PTV showed a similar distribution of CNS lesions. Histological lesions in the CNS caused by oral or intranasal inoculation of the virus were mild compared with those induced by intravenous infection. Immunohistochemically, the distribution of PTV antigens corresponded closely with the distribution of brain lesions. PTV particles were detected via electron microscopy in the cytoplasm of nerve cells and the endothelial cells of blood vessels in the spinal cord of inoculated pigs. Polymerase chain reaction analysis demonstrated the presence of PTV RNA in the CNS, tonsils and large intestines of 21 of the 22 pigs inoculated. Direct CNS invasion via the blood vessels appears to be a major route of infection for PTV. The gnotobiotic pig provides a useful model for further study of PTV pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Experimental Teschovirus Encephalomyelitis in Gnotobiotic Pigs

Yamada

Miyazaki

Yamamoto

et al. 2014

Journal of Comparative Pathology

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“…Several new serotypes were identified in the 1960s. The spectrum of diseases caused by teschoviruses ranges from severe or mild neurological disorders known as Teschen/Talfan disease to reproductive failure (SMEDI syndrome; with the characteristic symptoms of stillbirth, mummification, embryonic death, and infertility), pneumonia, rhinitis, diarrhea, myocarditis, and pericarditis [3,4,[6][7][8][9][10]. Today, PTV infections of pigs are enzootic in many regions, but severe symptoms occur rarely.…”

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confidence: 99%

Phylogeny and evolution of porcine teschovirus 8 isolated from pigs in China with reproductive failure

2012

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A porcine teschovirus (PTV) was isolated from a dead piglet from a herd of 200 sows showing reproductive failure in Fuyu, Heilongjiang Province, China. Sequencing of most of the genome of this isolate, designated Fuyu/2009, revealed that is was a PTV-8 isolate, closely related to a previously identified Chinese PTV-8 strain (Jilin/2003). Both Chinese strains vary from the European PTV-8 strains by different clustering of the 3CD sequences. Infection with these viruses may be associated with pronounced diseases.

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“…There have been many studies of both naturally and experimentally induced PTV infection in pigs [1,3,5,11,13,14,17,19,20]. Previously, the organ tropism of PTV infection was examined by virus isolation [1,20].…”

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Immunohistochemical Distribution of Viral Antigens in Pigs Naturally Infected with Porcine Teschovirus

Yamada

Kozakura

Kaku

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. A distribution of porcine teschovirus (PTV) antigens in pigs naturally infected with PTV is presented using the method of immunohistochemical examination. In the nervous system, PTV antigens were found in the cytoplasm of neuronal cells and glial cells distributed in the spinal ventral horn and brain stem, and also in the cytoplasm of ganglion cells in the spinal ganglion. No antigens were seen in the cerebral hemisphere. In the nervous system, the distribution of PTV antigens was consistent with lesions characteristic of nonsuppurative encephalomyelitis. In the other examined organ, PTV antigens were observed in bronchiolar epithelial cells in the lung, hepatocytes in the liver, epithelial cells in the tonsils and the myenteric nerve plexus in the small and large intestine. KEY WORDS: immunohistochemistry, porcine teschovirus, swine.

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Pathogenicity of Talfan and Konratice strains of Teschen virus in gnotobiotic pigs

Cited by 23 publications

References 5 publications

Experimental Teschovirus Encephalomyelitis in Gnotobiotic Pigs

Experimental Teschovirus Encephalomyelitis in Gnotobiotic Pigs

Phylogeny and evolution of porcine teschovirus 8 isolated from pigs in China with reproductive failure

Immunohistochemical Distribution of Viral Antigens in Pigs Naturally Infected with Porcine Teschovirus

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